Can a mechanical heart pump offer a lifeline for advanced heart failure?
NCT ID NCT04915924
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study follows up to 300 people with advanced heart failure in South Korea who receive a HeartMate 3, a mechanical pump that helps the heart circulate blood. Researchers will track how long patients survive without a debilitating stroke or the need for a pump replacement, as well as their ability to walk and overall heart function. The goal is to see how well this device performs in real-world clinical practice as a long-term support option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HeartMate 3 left ventricular assist system (LVAS), a mechanical heart pump implanted to help the heart pump blood
- What this could lead to
- If successful, this could confirm the HeartMate 3 as a safe and effective long-term support option for people with advanced heart failure, potentially improving survival and quality of life.
- What could go wrong
- This is an observational post-market study, not a randomized trial, so results may be influenced by patient selection. Risks include bleeding, stroke, infection, and device malfunction, which the study tracks closely.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
Seoul, South Korea
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Chonnam National University Hospital (CNUH)
Gwangju, Gwangju, 58128, South Korea
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Chungnam National University Hospital
Daejeon, South Korea
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Gachon University Gil Hospital
Incheon, South Korea
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Gangnam Severance Hospital
Seoul, South Korea
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Gyeongsang National University Changwon Hospital
Changwon, South Korea
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Hallym University Dongtan Sacred Heart Hospital
Hwaseong, South Korea
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Hallym University Sacred Heart Hospital
Hwaseong, South Korea
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Incheon Sejong Hospital
Incheon, Nam-gu, 726, South Korea
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Keimyung University Dongsan Medical Center
Daegu, South Korea
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Korea University Anam Hospital
Seoul, South Korea
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Korea University Ansan Hospital
Ansan, South Korea
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Kyungpook National University Hospital
Daegu, South Korea
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Pusan National University Hospital
Busan, South Korea
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Pusan National University Yangsan Hospital
Yangsan, South Korea
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Samsung Medical Center
Seoul, South Korea
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Sejong Hospital
Bucheon-si, South Korea
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Seoul National University Bundang Hospital
Seongnam-si, South Korea
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Seoul National University Hospital
Ihwa-dong, South Korea
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Seoul St. Mary's Hospital
Seoul, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, South Korea
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St. Mary's Hospital, The Catholic University of Eunpyeong
Seoul, South Korea
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