Could eccentric exercise be the key to stronger hearts?

NCT ID NCT07636343

Recruiting now Symptom relief Sponsor: University Hospital, Antwerp Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a special type of exercise called eccentric training (where muscles lengthen under tension) can help people with heart failure and reduced pumping ability. Researchers will compare eccentric bike and strength training to standard cardio and strength exercises. The goal is to see if the new approach is safe, doable, and better at improving muscle strength and walking ability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: eccentric bike training and eccentric overload strength training
What this could lead to: If successful, this could offer a more effective exercise option for heart failure patients to improve muscle strength and daily function.
What could go wrong: This is a very small, early-stage study (only 3 participants) testing feasibility, so results may not apply widely. The training is also physically demanding, which some patients may not tolerate.

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Conditions

The condition(s) this trial relates to.

systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HFREF - HEART FAILURE WITH REDUCED EJECTION FRACTION STRENGTH TRAINING EFFECTS

Contacts and locations

Locations

UHAntwerp
RECRUITING

Edegem, 2850, Belgium

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