Cure My Disease

Don't miss your cure!

 Log in / Sign up

Heart device showdown: could CCM beat CRT for chagas patients?

NCT ID NCT05519046

Recruiting now Disease control Sponsor: InCor Heart Institute Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study compares two implantable heart devices—Cardiac Contractility Modulation (CCM) and Cardiac Resynchronization Therapy (CRT)—in people with Chagas heart disease and advanced heart failure. The goal is to see which device better improves quality of life and heart function. Participants must have Chagas infection, severe heart failure, and a specific heart rhythm pattern.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Cardiac Contractility Modulation (CCM) device
What this could lead to
If CCM works better than CRT, it could offer a new treatment option for people with Chagas-related heart failure who do not benefit from standard therapy.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to everyone. Devices carry risks like infection or device malfunction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHAGAS CARDIOMYOPATHY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bundle branch block, familial isolated complete right Chagas cardiomyopathy heart failure progressive familial heart block, type 1A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHAGAS CARDIOMYOPATHY HEART FAILURE RIGHT BUNDLE BRANCH BLOCK AND LEFT ANTERIOR FASCICULAR BLOCK RIGHT BUNDLE BRANCH BLOCK AND LEFT POSTERIOR FASCICULAR BLOCK SYSTOLIC DYSFUNCTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • InCor - HCFMUSP

    RECRUITING

    São Paulo, São Paulo, 05403-900, Brazil

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.