Heart failure

This phase 3 trial investigates whether adding acetazolamide—a drug often used for altitude sickness—to standard diuretics can improve fluid removal in people with heart failure who experience sudden fluid buildup. Participants take the medication for up to five days while being …

This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether a newer pacing method, called left bundle branch area pacing, is better than the standard right ventricular pacing for adults with permanent atrial fibrillation and a need for a pacemaker. The goal is to see if the newer technique reduces the risk of deat…

This phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…

This trial investigates whether a minimally invasive procedure called mitral valve TEER, added to standard medical therapy, improves outcomes for heart failure patients whose mitral valve leakage becomes severe only during exercise. Participants are randomly assigned to receive e…

This trial tests whether repairing a leaky mitral valve early, using a minimally invasive clip procedure, can help people with heart failure and reduced pumping function tolerate and benefit from standard heart failure medications. Participants are randomly assigned to receive th…

This trial is testing a new mechanical heart pump called the DuoCor 2, designed to support both sides of the heart in people with advanced heart failure. The study will enroll 64 patients who are severely ill and need circulatory support. The main goal is to see if the device hel…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

This trial investigates whether a daily dose of alpha-lipoic acid, a vitamin-like antioxidant, can lower the risk of major heart problems in people with chronic heart failure caused by coronary artery disease. Researchers will compare the supplement against a placebo in over 1,50…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial investigates whether a high-protein diet, with or without an HMB supplement, can improve muscle mass, strength, and physical function in people with heart failure. Participants are randomly assigned to one of three groups: a standard-protein diet, a high-protein diet, …

This study tests whether a best-practices checklist can help emergency doctors manage acute heart failure more effectively. The checklist guides assessment, treatment, and decisions about whether to admit or discharge patients. Researchers are introducing the checklist in four la…

This trial tests whether a year-long, supervised exercise program — including aerobic, resistance, and breathing exercises — can improve outcomes for people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either usual care or usu…

This trial tests whether a nurse-led education program can improve self-care knowledge in people with heart failure in Rwanda. About 400 participants from three district hospitals will receive illustrated flip-book teaching and a simplified handout. The study measures changes in …

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This study tests whether using a real-time continuous glucose monitor (CGM) can improve blood sugar control and reduce hospital readmissions in people with type 2 diabetes and acute heart failure. Researchers will follow 140 adults during their hospital stay and for three months …

This study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…

This trial tests a device called the Corheart 6, a left ventricular assist system that helps pump blood in people with advanced left ventricular heart failure. The study includes 100 adults aged 18 to 75 with severe heart failure symptoms despite optimal medical therapy. The main…

This study tests whether a nurse-led discharge education program helps heart failure patients avoid unplanned hospital readmissions within 30 days. The program includes an educational assessment, a discharge session using the teach-back method, and a follow-up phone call. Researc…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This study tests whether a personalized high-intensity interval training (HIIT) program can improve exercise capacity and quality of life in people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either a 24-week HIIT plan tailor…

This study looks at whether giving doctors—and sometimes patients—personalized reports on recommended heart failure treatments helps more people get the right medications. It involves adults with heart failure and reduced ejection fraction (HFrEF) in the Netherlands. The goal is …

This trial investigates whether vericiguat, added to standard treatment, can improve quality of life and reduce hospitalizations in adults with heart failure and reduced ejection fraction. Participants receive either vericiguat or a placebo for six months, and their health status…

This study compares two pacing methods in 80 people with heart failure and a specific heart block. One method uses a lead placed in the left bundle branch area; the other adds a second lead in the left ventricle. Each participant will try both methods for six months to see which …

This study tests a four-month digital program designed to help people with chronic heart failure take their medications as prescribed. The program includes personalized planning, motivational counseling, and symptom tracking. Researchers will enroll 870 adults in Pakistan who hav…

This study tests a small, hourglass-shaped device implanted in the heart's upper chambers to lower pressure and reduce fluid buildup in the lungs. It is for people with advanced heart failure whose heart pumps weakly (ejection fraction 40% or less). The trial randomly assigns som…

This study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…

This study tests whether wearable devices like smartwatches and ECG straps can help doctors remotely manage patients with both heart failure and atrial fibrillation. Participants use the devices to send real-time health data to their care team, who adjust medications and treatmen…

This study tests whether adding a combination of an SGLT-2 inhibitor (henagliflozin) and a probiotic to standard heart failure treatment can improve heart function and quality of life in people over 60 with a specific type of heart failure called HFpEF. The trial randomly assigns…

This study tests whether giving doctors daily readings of a patient's peripheral venous pressure (a simple vein pressure measurement) can help heart failure patients get out of the hospital faster and avoid coming back. Researchers will compare 600 patients who get this extra inf…

This trial tests a nurse-led program designed to help people with chronic heart failure better manage fluid buildup—a common cause of hospital readmission. The program includes education, emotional support, and practical skills like daily weighing and salt restriction. Researcher…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, reduce hospitalizations, and boost quality of life in adults aged 65 and older who have heart failure with preserved ejection fraction and iron deficiency. Participants receive…

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This platform trial will enroll 1,000 adults with heart failure to test several different treatments at the same time. Participants are randomly assigned to either an experimental intervention or standard care. The main goal is to see if these treatments can prevent death or hosp…

This early-stage study tests a new treatment called HiCM-188, made from stem cells that become heart muscle cells. It is given as a single injection into the heart during bypass surgery in 12 adults with severe heart failure. The main goal is to check safety and see if it improve…

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…

This study tests a wearable device that tracks heart rate, breathing, activity, and fluid buildup in people recently hospitalized for heart failure. 800 participants will either get standard care or standard care plus the device for 90 days. The goal is to see if early alerts fro…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This study tests whether using detailed PET-CT scans to guide where a pacemaker lead is placed can improve heart function in 20 people with heart failure. Participants will receive a standard pacemaker, but the lead position will be chosen based on scan data. The goal is to see i…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…

This study tests whether measuring sodium in urine can help doctors give the right amount of diuretics (water pills) to people hospitalized with worsening heart failure. About 260 adults will be split into two groups: one gets standard care, the other gets treatment guided by uri…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve quality of life and exercise ability in elderly patients with a common type of heart failure (HFpEF). Fifty adults aged 60 and older will receive either the transplant or a …

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests whether a structured heart-health program can improve heart outcomes in 800 cancer survivors who have heart problems or high heart risk. The program includes exercise, nutrition advice, stress support, and risk-factor management over 12 months. Researchers will c…

This study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either…

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study tests three different ways to remove excess fluid in people with worsening heart failure. Participants will receive intravenous furosemide alone, or combined with either acetazolamide or hydrochlorothiazide. The goal is to see which combination works best and is safest…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This study tests whether a potassium binder called Sodium Zirconium Cyclosilicate can help heart failure patients take higher, more effective doses of a standard medication (aldosterone receptor antagonist) without dangerous potassium spikes. About 110 adults over 70 with heart f…

This study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…

This study tests whether creating a small opening between the upper heart chambers during mitral valve repair can prevent heart failure symptoms after surgery. Researchers will compare 50 patients who get the extra opening to those who have standard surgery alone. The goal is to …

This study tests whether people hospitalized for acute heart failure can be discharged early and continue treatment at home using a subcutaneous injection of furosemide (a diuretic) instead of staying in the hospital for standard IV diuretics. About 250 adults will be randomly as…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study tests a procedure called renal denervation (RDN) in 20 people with heart failure. Doctors use a thin tube to deliver radiofrequency energy to nerves around the kidney arteries, aiming to reduce stress on the heart. Participants continue their usual heart failure medica…

This study tests whether adjusting diuretic doses based on urine sodium levels improves outcomes for people hospitalized with acute heart failure and severe fluid buildup. About 270 participants will be randomly assigned to either standard care or a strategy where diuretic doses …

This study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…

This study tests a new device called DuoCor 2, which is a mechanical pump that helps both sides of the heart pump blood. It is for people with advanced heart failure in both ventricles who have few other options. The study will enroll 50 adults and measure how many survive for 6 …

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study tests a special pacing method for people with heart failure and a type of heart block. The goal is to see if pacing a specific area of the heart can improve heart function and quality of life. About 120 adults with heart failure and reduced pumping ability will partici…

This study tests whether AI-generated messages can help doctors improve medication plans for adults with heart failure. About 500 patients will have their doctors receive brief suggestions before appointments. The goal is to see if more patients get the right medications within 3…

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study tests a new method to guide where a pacing lead is placed in the heart's upper chambers during cardiac resynchronization therapy for heart failure. Researchers will use a special catheter to map electrical signals and target a specific area called Bachmann's bundle. Th…

This registry will follow 200 people with severe aortic valve stenosis who receive a non-invasive ultrasound therapy called Valvosoft. The treatment uses focused sound waves to soften calcium buildup on the valve without surgery. Researchers will track safety and effectiveness fo…

This study looks at whether giving lower doses of two blood thinners (argatroban and enoxaparin) to adults on ECMO (a machine that helps the heart and lungs) is safe and works well. The goal is to reduce bleeding and clotting problems. About 200 people with pneumonia or heart fai…

This study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimiz…

This study tests whether dapagliflozin, a drug already used for diabetes, can improve heart function in people hospitalized with acute heart failure. About 188 participants will take the drug or not for three months, and doctors will use special ultrasound imaging to measure chan…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This study tests whether using a special ultrasound score (DUCS) to guide diuretic dosing can improve outcomes for people hospitalized with acute heart failure. About 128 adults with heart failure and fluid buildup will be randomly assigned to either standard care or ultrasound-g…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests a new adjustable cooler for storing donor hearts during transport to the transplant hospital. The cooler aims to keep the heart at a steady temperature, reduce waste, and lower costs compared to the current standard device. About 80 adults receiving a heart trans…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This early-stage trial tests whether a patch loaded with lab-grown heart muscle cells can help repair damaged heart tissue. Sixteen people with severe heart failure who are already scheduled for bypass surgery will receive either the stem cell patch or a blank patch during their …

This study tests whether setting a pacemaker to a faster rate (90 beats per minute) can help people with right heart failure and severe tricuspid regurgitation. Twenty-four participants with a low resting heart rate will get a special pacemaker implant and be followed for 6 month…

This study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This study tests whether remote motivational interviewing—online chats with a trained nurse—can help heart failure patients and their family caregivers improve self-care and quality of life. 600 participants (300 patients with moderate to severe heart failure and their caregivers…

This study looks at how well the drug Jardiance works compared to other standard heart failure treatments in Chinese patients with a specific type of heart failure (HFrEF). Researchers will track about 5,000 adults to see which treatment better prevents heart failure hospitalizat…

This study looks at whether an implantable defibrillator (ICD) can reduce the risk of sudden cardiac death in people with non-ischemic dilated cardiomyopathy, a type of heart muscle disease not caused by blocked arteries. Researchers will use MRI scans to find heart scarring (fib…

This study tests whether adding HeartLogic diagnostic alerts to usual care can reduce hospitalizations and improve quality of life for people with chronic heart failure and low ejection fraction. About 135 adults with a prior heart failure event will be enrolled. The approach use…

This early-stage trial tests whether a catheter-based procedure that zaps a nerve near the spine can safely help people with heart failure with reduced ejection fraction. Up to 50 patients will be randomly assigned to get the real treatment or a sham procedure, and neither they n…

This phase 2 trial tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment improves heart function and symptoms. Researchers will enroll 200 stable heart failure patients with low ejection fraction (under 40%). Participants will receive either L…

This study looks at whether starting the drug dapagliflozin within 24 hours of arriving at the emergency room is practical for elderly patients (75+) with acute heart failure. It will involve 144 patients across 6 hospitals, comparing early drug treatment plus a nurse phone call …

This study tests whether an artificial intelligence (AI) system can help doctors manage medications for people with heart failure with reduced ejection fraction (HFrEF). About 1,200 participants from 60 hospitals will be assigned to either AI-guided care or standard care. The goa…

This study tests whether a national hospital accreditation program for heart failure centers can improve care and outcomes for patients hospitalized with heart failure. About 6,240 adults across multiple hospitals in China will be followed for 12 months after discharge. The progr…

This study tests whether using remote blood pressure monitors and video doctor visits can help people living in rural areas better manage their heart failure. Researchers will enroll 32 adults with heart failure to see if this approach is practical and acceptable. The goal is to …

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This study tests whether adding finerenone to standard heart failure treatment (an SGLT2 inhibitor) can reduce deaths and hospitalizations. About 60 adults aged 18-65 with newly diagnosed heart failure will be split into two groups: one gets the standard drug alone, the other get…

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or heart pump. Participants will receive either a standard implantable defibrillator (ICD) alone or an ICD plus a special pacing lead a…

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard heart failure medications can help people with chronic heart failure walk farther and improve heart function. About 150 adults with reduced heart pumping abil…

This study looks at whether reducing the number of kidney function tests during heart failure treatment helps patients reach the best medication doses more safely. About 344 adults with heart failure and reduced ejection fraction will take part. The goal is to improve drug dosing…

This Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …

This Phase 3 trial tests whether a continuous infusion of alprostadil, a drug that widens blood vessels, can help maintain stability in 600 people with advanced heart failure. Participants receive either the drug or a placebo for 6 months. The main goal is to see if the drug redu…

This study tests whether using a smartwatch combined with artificial intelligence can improve recovery for people who have had a heart attack. 200 adults aged 18-75 who recently had a heart attack and a stent placed will wear a smartwatch that tracks health data. The AI analyzes …

This study looks at whether a 30-minute face-to-face lesson with a nurse can help people with chronic heart failure stay stable and take better care of themselves after being discharged from the hospital. About 118 adults will be randomly assigned to either receive this extra edu…

This phase 3 trial tests whether the drug finerenone (Kerendia) can improve heart structure and function in 156 adults with heart failure and an enlarged left ventricle. Participants take finerenone or a placebo daily for 12 months, alongside standard care. Heart changes are meas…

This study looks at whether roxadustat, a drug for anemia in chronic kidney disease, can also help people with heart failure. Researchers will review medical records of 200 patients who took roxadustat for at least a year. They will check heart function, symptoms, and major event…

This study tests whether levosimendan, a drug that strengthens heart contractions without increasing oxygen demand, can help people hospitalized with acute decompensated heart failure. About 332 adults will receive either levosimendan plus standard care or standard care alone. Re…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This early-stage trial tests a single injection of SHR-4658 in 48 healthy volunteers and people with slightly high blood pressure. The main goal is to check safety and how the body processes the drug. If it passes safety checks, it may lead to larger studies for heart failure tre…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study looks at whether the drug sacubitril/valsartan (Entresto) can improve the heart's ability to relax in people with heart failure and reduced pumping strength. Researchers will use ultrasound to measure changes after six months of treatment. The study involves 70 adults …

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study aims to build a comprehensive prediction rule for diagnosing acute heart failure in the emergency department. It will enroll 560 adults with suspected heart failure or acute shortness of breath. Participants will undergo standard tests, including blood work, lung ultra…

This study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…

This study explores whether specialized eye imaging can identify people with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). Researchers will use machine learning to analyze eye scans from 500 adults—some with ATTR-CM and others with heart failure bu…

This study evaluates whether a quick blood test for NT-pro-BNP, done in a doctor's office, can help diagnose heart failure earlier in rural areas where specialists are scarce. The test is given to people over 60 with symptoms like shortness of breath or swelling. Researchers will…

This study will test whether an algorithm that analyzes data from Withings smart scales (weight, body water, and step counts) can accurately detect heart failure. Researchers will look back at data from 9,000 people aged 45 and older in the US. If the algorithm works well, it cou…

This study evaluates a simple questionnaire designed to detect decompensated heart failure—a sudden worsening of heart failure—in people aged 55 and older on Réunion Island. Researchers will compare the questionnaire's results with standard heart exams (echocardiogram, ECG, and c…

This study tests whether an artificial intelligence (AI) program can help doctors identify a rare heart condition called cardiac amyloidosis on routine echocardiograms. The condition causes protein buildup in the heart muscle, leading to heart failure, and is often missed early o…

This pilot study will test whether an AI-assisted ultrasound device can help emergency doctors quickly detect heart failure in patients with symptoms. About 84 adults visiting the ER with signs of heart failure will be enrolled. The goal is to see if this approach is practical an…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study will test a rapid finger-prick blood test for heart failure in 618 people with leg swelling (lymphoedema) who have not been diagnosed with heart failure. The test measures a substance called NT-proBNP and gives results in 12 minutes, compared to the usual lab test that…

This study will test new ultrasound techniques, combined with artificial intelligence, to more accurately measure heart filling pressure in patients who have both heart failure and atrial fibrillation. Current methods are unreliable for these patients, making diagnosis and treatm…

This study explores whether general practitioners can use a tiny ultrasound device to detect early signs of heart disease during a routine office visit. Researchers will enroll 300 adults aged 65 and older with risk factors, or adults with symptoms like shortness of breath or leg…

This study tests whether a new risk algorithm (FIND HF) can better detect undiagnosed heart failure in people at risk. About 475 adults aged 40+ will have a blood test and heart ultrasound. Researchers will compare how many high-risk vs low-risk people are found to have heart pro…

This study will check how well a heart surgeon's visual estimate of the heart's pumping ability matches the more precise measurement from an ultrasound (TEE) during open-heart surgery. About 70 adults having planned heart surgery with a heart-lung machine will take part. The goal…

This study looks at whether a quick, painless liver scan (FibroScan) can accurately detect high central venous pressure in people with heart failure. Currently, doctors use a catheter inserted into the heart to measure this pressure, which carries risks. The study will enroll 149…

This study checks if a new test kit (NTproBNP2) works as well as an existing approved test for measuring a substance linked to heart failure. Researchers will compare results from 120 blood samples of people with or suspected of having heart failure. The goal is to confirm the ne…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. The drink is given three times a day for five days. Researchers will measure changes in heart stress markers and symptoms. The goal is to see if ketones can improve energy for t…

This trial tests whether slow-paced breathing—reducing breaths to 4-7 per minute—can improve heart rate variability, a marker of heart health, in hospitalized heart failure patients. Participants will be randomly assigned to either standard cardiac rehab alone or rehab plus slow-…

This study tests whether a mobile health program can help people with heart failure increase their physical activity and stay active. The program includes a smartphone app for goal-setting and self-monitoring, an AI-based health coach trained in motivational interviewing, and occ…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests a new type of breathing muscle training for people with heart failure. 108 participants will either do the new breathing exercise, a standard one, or usual care for 8 weeks. Researchers will measure if it improves exercise capacity, breathing strength, and qualit…

This study compares two types of exercise—moderate-intensity aerobic training and high-intensity interval training (HIIT)—in women aged 40-70 with stable heart failure. Over 12 weeks, researchers measure how each program affects functional capacity (e.g., walking distance) and qu…

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…

This study tests two types of exercise—aerobic and resistance—both combined with blood flow restriction (using cuffs on the legs) in 40 people with stable heart failure. The goal is to see which approach better improves muscle oxygen levels, heart stress markers, daily function, …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist air through the nose) can help people with heart failure exercise longer during cardiac rehab. Twenty-eight adults will do two treadmill tests—one with the device and one without—to compare end…

This study tests whether a 12-week home exercise program, guided by a mobile app and smartwatch, can improve exercise capacity and quality of life in people with a left ventricular assist device (LVAD). About 78 participants who recently got an LVAD and cannot attend hospital reh…

This study tests whether an 8-week home telerehabilitation program, with real-time coaching and vital sign monitoring, can improve physical function and reduce frailty in older adults with heart failure. Seventy participants will be randomly assigned to either the telerehab progr…

This study tests whether a structured medication training program delivered via WhatsApp can help people with heart failure better manage their symptoms and stick to their medication routine. Researchers will compare the training group to a group receiving standard care. The stud…

This study tests whether a supervised 8-week exercise program can improve physical function and exercise ability in people with advanced heart failure who are hospitalized and waiting for a heart transplant. Participants will do aerobic and resistance exercises while receiving IV…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study compares two supervised exercise programs—neuromuscular training (focusing on balance and coordination) and resistance training (using weights and bands)—in 40 adults with chronic heart failure. Over 10 weeks, researchers will measure how far participants can walk, the…

This study tests whether a structured 5-week cardiac rehabilitation program can improve exercise ability and quality of life in 40 adults with cardiac amyloidosis. Participants will undergo supervised aerobic and strength training five days a week, with tests before and after the…

This study tests whether a guided breathing technique called heart rate variability biofeedback (HRVB) can reduce anxiety in 60 adults who are in the ICU waiting for a heart transplant. Participants will use a biofeedback device or app during a single session led by a trained cli…

This study is testing whether a mobile app can help people with heart failure take better care of themselves after leaving the hospital. The app provides educational tips, symptom tracking, and ways to communicate with the care team. Thirty participants will use the app alongside…

This study looks at whether adding sauna therapy to standard cardiac rehabilitation can help people with heart failure feel less congested and possibly lower their dose of water pills (diuretics). About 46 adults with heart failure and reduced pumping ability will be randomly ass…

This study looks at whether combining aerobic exercise, breathing exercises, and cognitive training can improve physical function and thinking in men aged 50-65 with acute heart failure. Forty participants will undergo these combined therapies while in the hospital. The goal is t…

This study looks at whether adding a palliative care team—specialists in comfort and holistic support—can improve quality of life for people who have had a mechanical heart pump (LVAD) for at least a year. About 90 adults who are not eligible for a heart transplant will be random…

This study tests a flexible palliative care program for people with advanced heart failure or certain cancers. The program adds more team members—like a social worker or nurse—as symptoms get worse. The goal is to improve quality of life and match care to each person's changing n…

This study tests whether pulsatile compression boots, which rhythmically squeeze the legs, can help patients hospitalized with acute heart failure and leg swelling. The boots aim to move fluid out of the legs, improve circulation, and support heart and kidney function. One hundre…

This study will test a cardiac rehabilitation program designed for people over 65 with heart failure. Participants will attend supervised exercise and education sessions twice a week for three months, starting while still in the hospital. The goal is to see if the program improve…

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This study tests whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions. Participants will try both HFNC and standard oxygen therapy for two weeks each …

This study tests a personalized system that uses a mobile app and smart wristband to encourage physical activity in 82 adults with heart failure. Participants get custom activity goals, real-time feedback, and motivational support over 12 months. The goal is to see if this approa…

This observational study looks at whether changes in a blood marker called NT-proBNP, measured at the bedside, can reflect how well fluid is being removed in patients hospitalized with acute decompensated heart failure. Participants receive standard care, and researchers track NT…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

This study tests two different formulations of an experimental drug called AD-118 in healthy adults aged 19 to 64. Participants receive a single dose of each version in a random order, and researchers measure how the drug moves through the body and check for side effects. The goa…

This study looks at how the stiffness and function of blood vessels change in people newly diagnosed with heart failure. Researchers will measure these factors at the start, after a few weeks of standard medication, and after a cardiac rehab program. All tests are non-invasive an…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study will observe how the Impella 5.5 heart pump changes the way the heart squeezes and works in adults with end-stage heart failure. Researchers will use ultrasound (echocardiography) to measure heart function before, right after, and 7-14 days after the pump is placed. Th…

This study will test whether a five-point ultrasound can better predict fluid overload in 200 patients hospitalized with congestive heart failure. Doctors will use the ultrasound results to guide diuretic treatment and track readmission rates over 30 and 90 days. The goal is to s…

This study gathers data from 392 adults with heart failure who need a right heart catheterization. Researchers will use the data to train a machine learning model for a non-invasive device that estimates heart pressure. The goal is to help doctors monitor and treat heart failure …

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study tests a new home monitoring system called AVATAR-SC that uses a digital avatar to collect voice recordings and symptom questionnaires from heart failure patients. The goal is to see if changes in voice can serve as early warning signs of worsening heart failure. Sixty …

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This observational study will follow 600 adults with chronic or acute heart failure to see how biomarkers and other factors predict individual responses to standard medications. Participants will have assessments at the start and after 1, 3, and 6 months, with follow-up phone cal…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study will look at medical records from over 2 million adults who had surgery in Sweden between 2021 and 2024. Researchers want to see how common heart failure is in surgical patients and whether it raises the risk of death or other problems after surgery. The goal is to bet…

This study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will enroll 1000 heart failure patients to see if different types of body fat—around the heart, under the skin, and within muscles—are linked to heart structure and future health events like heart attacks or strokes. Researchers will use CT scans to measure these fat d…

This study checks if two Italian questionnaires accurately measure how well people with heart failure care for themselves and how caregivers help. Researchers will enroll 1,000 patients and their caregivers across Italy. The goal is to improve heart failure management by using re…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at 223 adults hospitalized with acute heart failure to see if changes in urine salt levels (sodium and chloride) can help doctors understand how well the body is getting rid of extra fluid. Participants will have blood and urine tests, heart ultrasounds, and chec…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study looks at whether a special simulation training program for emergency doctors can help them use heart ultrasound more effectively in patients with acute heart failure. The goal is to see if this training leads to faster treatment with diuretics, which help remove excess…

This observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of st…

This study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study will follow 200 people with suspected or confirmed cardiac amyloidosis, a condition where abnormal proteins build up in the heart and cause heart failure. Over two years, participants will undergo heart MRI scans, exercise tests, and blood work at regular visits. The g…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…

This study will follow 2000 adults hospitalized with acute heart failure in Brazil to learn how they are treated and what happens to them over the next year. Researchers want to see if doctors are using the latest recommended medicines and find out what barriers prevent better ca…

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study tests a simple idea: showing heart failure patients easy-to-understand pictures of how their medications can help them live longer and stay out of the hospital. About 100 adults with heart failure will receive these visual aids along with their usual care. Researchers …

This study will check how well heart failure and atrial fibrillation patients take their medicines after being admitted to the coronary care unit. Researchers will interview 250 adults to understand their medication beliefs and whether their prescriptions are appropriate. The goa…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This observational study will enroll 30,000 adults in Denmark to better understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff to fill properly. Researchers will use blood tests, heart imaging, and health rec…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This early-stage study will test two versions of a drug (AD-118 and AD-1181) in 70 healthy adults to see how they are processed by the body and if they are safe. Participants will receive a single dose of each version under fasting conditions. The study does not aim to treat any …

This study will create a registry of about 120 patients in Poland who have carcinoid heart disease, a rare complication of neuroendocrine tumors that damages heart valves. Researchers will collect medical records, echocardiograms, and lab results to better understand who develops…

This study looks at how different levels of breathing support (PEEP) affect blood flow congestion in the veins of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidney, and portal veins as absent, modera…

This study looks at whether a remote monitoring model called RAPHAEL can work for people with heart failure who may need palliative care. About 90 adults will use a digital questionnaire for 4 weeks to report symptoms and needs, while their healthcare team reviews the results. Th…

This study looks at 200 adults with a type of heart failure called HFpEF. Researchers will use medical records and exercise tests to find different patient groups, or phenotypes. The goal is to better understand these groups, not to test any new treatment. Participants will have …

This study will observe 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers will track how many patients are hospitalized for heart failure or die from heart-related causes over time. The goal is to see how effective an…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at 600 people (400 with chronic heart failure and 200 healthy) to find patterns in genes, proteins, and gut bacteria that may predict who gets worse. Researchers will track patients for one year to see who is hospitalized or dies. The goal is to create a better r…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This observational study will enroll 112 adults hospitalized for heart failure with preserved or mildly reduced ejection fraction. Researchers will collect blood and urine samples to measure inflammatory biomarkers and analyze genetic factors. The goal is to identify markers that…

This study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…

This study aims to see if a new heart ultrasound technique, called myocardial work, can predict which patients will respond to cardiac resynchronization therapy (CRT) for heart failure. Researchers will also establish normal heart ultrasound values in healthy Chinese adults. The …

This study looks at whether certain blood markers can predict delirium (sudden confusion) in older adults with heart failure. Researchers will compare two markers: one for inflammation (SII) and one for blood sugar and fat levels (TyG). They aim to find a simple way to identify h…

This study will measure a specific heart function index in 2,640 healthy adults and people with heart conditions using AI-enhanced 3D ultrasound. The goal is to establish normal ranges and see how this measurement changes in diseases like heart failure and high blood pressure in …

This study looks at 300 adults hospitalized with heart failure to see if iron deficiency (with or without anemia) is linked to abnormal heart rhythms or ECG changes. Researchers will measure iron levels and monitor for arrhythmias like atrial fibrillation or ventricular tachycard…

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This study looks at 40 adults with atrial fibrillation and heart failure to see if lowering their resting heart rate from 100-110 bpm to a more normal level improves exercise ability and quality of life. Participants will do treadmill tests before and after either a cardioversion…

This study will check if three heart failure risk models (MAGGIC, GWTG-HF, and SHFM) accurately predict outcomes like death and hospital readmission in 140 Egyptian patients. These models were developed using mostly Western patients, so they may not work well for Egyptians, who t…

This study will use echocardiography (ultrasound of the heart) to look at how common and how severe diastolic dysfunction—a type of heart stiffness—is in 100 adults with end-stage kidney disease who are on regular hemodialysis. Researchers will also check if certain clinical fact…

This study aims to better understand heart failure by deeply analyzing the genes, proteins, and other molecules in patients' blood and tissues. Researchers will enroll 500 adults with heart failure and combine detailed clinical data with advanced lab tests. The goal is to find mo…

This study looks at whether a hybrid care model—using telemonitoring, teleconsultations, and online tools—can help patients with type 2 diabetes or chronic heart failure get regular care during health emergencies like pandemics. Researchers will follow 180 patients for one year, …

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…