New procedure targets nerves to treat stubborn heart failure
NCT ID NCT07331220
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either get PADN plus standard medications or a sham procedure plus medications. The goal is to see if PADN reduces deaths, hospitalizations, and need for advanced treatments over 12 to 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pulmonary artery denervation (a catheter-based procedure using radiofrequency energy to ablate nerves in the pulmonary artery)
What this could lead to
If successful, this procedure could become a new treatment option for heart failure patients with preserved ejection fraction, reducing hospitalizations and improving survival.
What could go wrong
This is an early-stage trial with a sham control, so results may not show benefit. The procedure involves risks like bleeding, infection, or damage to blood vessels.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, 210006, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••