New procedure targets nerves to treat stubborn heart failure
NCT ID NCT07331220
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either get PADN plus standard medications or a sham procedure plus medications. The goal is to see if PADN reduces deaths, hospitalizations, and need for advanced treatments over 12 to 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pulmonary artery denervation (a catheter-based procedure using radiofrequency energy to ablate nerves in the pulmonary artery)
- What this could lead to
- If successful, this procedure could become a new treatment option for heart failure patients with preserved ejection fraction, reducing hospitalizations and improving survival.
- What could go wrong
- This is an early-stage trial with a sham control, so results may not show benefit. The procedure involves risks like bleeding, infection, or damage to blood vessels.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, 210006, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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