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Heart fat may melt away after weight loss surgery, study hopes to show

NCT ID NCT07565610

Knowledge-focused Sponsor: Itshak Amsalem Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The goal is to see if losing weight through surgery lowers heart fat and improves diastolic function, which could help prevent heart failure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If heart fat decreases and function improves after weight loss surgery, this could point toward new ways to prevent or treat heart failure with preserved ejection fraction.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to people who do not have surgery or who have different health profiles.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with obesity who are scheduled to undergo bariatric surgery for standard clinical care at a tertiary medical center. Participants will be recruited during their preoperative evaluation and will undergo baseline and follow-up assessments, including cardiac imaging and clinical measurements, as part of the study.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Scheduled to undergo bariatric surgery for standard clinical indications * Left ventricular ejection fraction (LVEF) ≥50% * Able to undergo cardiac computed tomography (CT) Exclusion Criteria: * Left ventricular ejection fraction (LVEF) \<50% * Known cardiomyopathies, including sarcoidosis, amyloidosis, or myocarditis * Significant valvular heart disease * Contraindication to cardiac CT (e.g., severe renal dysfunction, contrast allergy) * Presence of intracardiac or cardiac-related foreign material that may interfere with imaging (e.g., prosthetic valves, pacemakers, prior transcatheter devices)

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Conditions

The condition(s) this trial relates to.

diastolic heart failure Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diastolic dysfunction Heart failure with preserved ejection fraction (hfpef) Obesity

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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