Could zapping a nerve ease heart failure? new trial tests it

NCT ID NCT07403058

Not yet recruiting Disease control Sponsor: Axon Therapies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a catheter-based procedure that zaps a nerve near the spine can safely help people with heart failure with reduced ejection fraction. Up to 50 patients will be randomly assigned to get the real treatment or a sham procedure, and neither they nor their heart doctor will know which they received. The study focuses on safety and early signs of benefit, not long-term effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter-based nerve ablation (Satera Ablation System)
What this could lead to: If it works, this could offer a new way to manage heart failure symptoms without drugs or surgery.
What could go wrong: This is a very early, small feasibility trial. The procedure may not work better than a sham, and there are risks like pain or blood vessel damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)

Contacts and locations

Locations

Hospital Clínico Universitario de Valencia-INCLIVA

Valencia, Spain
King's College London

London, United Kingdom
Leeds General Infirmary

Leeds, United Kingdom
Motol and Homolka University Hospital

Prague, Czechia
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wrocławiu

Wroclaw, Poland
Vithas Valencia Turia

Valencia, Spain

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