Could two pacing leads be better than one for failing hearts?

NCT ID NCT07526896

Not yet recruiting Disease control Sponsor: Medtronic Cardiac Rhythm and Heart Failure Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study compares two pacing methods in 80 people with heart failure and a specific heart block. One method uses a lead placed in the left bundle branch area; the other adds a second lead in the left ventricle. Each participant will try both methods for six months to see which improves heart function and quality of life more.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cardiac resynchronization therapy defibrillator (CRT-D) programmed for left bundle branch area pacing (LBBAP) or combined with left ventricular lead pacing (LOT-CRT)
What this could lead to: If successful, this could show that combining two pacing methods improves heart pumping and quality of life more than one method alone.
What could go wrong: This is a small, early feasibility study with only 80 participants. It may not prove long-term benefit, and results might not apply to all heart failure patients.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE SYSTOLIC BUNDLE BRANCH BLOCK, LEFT

More trials for these conditions

Other studies related to the condition(s) this trial covers.