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Tailored HIIT may boost fitness in stubborn heart failure

NCT ID NCT07693049

Disease control Sponsor: Peking University Third Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study tests whether a personalized high-intensity interval training (HIIT) program can improve exercise capacity and quality of life in people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either a 24-week HIIT plan tailored to their fitness test results or to standard care. The main goal is to measure changes in peak oxygen consumption, a key marker of heart and lung fitness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
personalized high-intensity interval training (HIIT)
What this could lead to
If it works, this could provide an effective, safe exercise program for people with heart failure with preserved ejection fraction, improving their fitness and daily life.
What could go wrong
This is a mid-sized trial, and the benefits may not be large or apply to all patients. High-intensity exercise carries risks for some heart patients, and the program requires commitment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 192 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Men and women aged 35-70 years; 2. Physical inactivity / sedentary lifestyle defined as: Sedentary behavior: average daily sitting time \> 6 hours over the past 6 months; AND/OR Insufficient physical activity: average weekly moderate-intensity physical activity \< 150 minutes or vigorous-intensity physical activity \< 75 minutes as assessed by the International Physical Activity Questionnaire (IPAQ); 3. Patients with HFpEF at Stage 4 of CKM syndrome who have been clinically stable within the past month (New York Heart Association \[NYHA\] functional class II-III); 4. Willingness to improve health status through appropriate exercise. Exclusion Criteria: 1. Presence of contraindications to cardiopulmonary exercise testing (CPET); 2. Positive findings on the exercise electrocardiogram (ECG) during CPET; 3. Diagnosis of psychiatric disorders; 4. Presence of movement disorders or lower extremity exercise-related injuries within the past 6 months; 5. Women who are pregnant, breastfeeding, or planning to become pregnant in the near future; 6. Other conditions deemed unsuitable for participation in this study by the investigators; 7. Refusal to sign the informed consent form.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hfpef - heart failure with preserved ejection fraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Chao-Yang Hospital, Capital Medical University

    Beijing, China

  • Beijing Hospital

    Beijing, China

  • Beijing Xiaotangshan Hospital

    Beijing, China

  • Beijing Zhongguancun Hospital

    Beijing, China

  • Community Health Station of the Party School of the Central Committee of C.P.C

    Beijing, China

  • Jimenli Community Health Service Center

    Beijing, China

  • Peking University First Hospital

    Beijing, China

  • Peking University People's Hospital

    Beijing, China

  • Peking University Third Hospital

    Beijing, China

  • Shanghai East Hospital

    Shanghai, China

  • Wuhan Asia Heart Hospital

    Wuhan, China

  • Xueyuanlu Community Health Service Center

    Beijing, China

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