Can a common amino acid boost heart function in failure patients?

NCT ID NCT07394270

Not yet recruiting Disease control Sponsor: German University in Cairo Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment improves heart function and symptoms. Researchers will enroll 200 stable heart failure patients with low ejection fraction (under 40%). Participants will receive either L-arginine powder or a placebo twice daily for a set period, and the study will measure changes in heart strain, symptoms, and exercise ability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-arginine powder
What this could lead to: If it works, this could point toward a simple, low-cost supplement to improve heart function and reduce symptoms in heart failure patients.
What could go wrong: This is an early phase 2 trial with only 200 participants, so results may not be conclusive. L-arginine may cause side effects or show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HEART FAILURE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE

Contacts and locations

Locations

Ain Shams University

Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.