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Exercise-Triggered heart valve leak targeted in new trial

NCT ID NCT07709208

Not yet recruiting Disease control Sponsor: Jena University Hospital Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial investigates whether a minimally invasive procedure called mitral valve TEER, added to standard medical therapy, improves outcomes for heart failure patients whose mitral valve leakage becomes severe only during exercise. Participants are randomly assigned to receive either medical therapy alone or medical therapy plus the TEER procedure. The study tracks deaths, heart failure hospitalizations, valve leakage progression, and quality of life over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Mitral valve transcatheter edge-to-edge repair (TEER) plus guideline-directed medical therapy
What this could lead to
If successful, this could establish a new treatment option for heart failure patients whose mitral regurgitation worsens only during exercise, potentially reducing hospitalizations and improving survival.
What could go wrong
This is a randomized trial, but the procedure carries risks such as bleeding, infection, or valve damage. The benefit may be small or limited to certain patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE - NYHA II - IV MITRAL REGURGITATION FUNCTIONAL

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Cardiology, Pneumology and Vascular Medicine University Hospital Düsseldorf

    Düsseldorf, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Department of Internal Medicine I (KIM I) Division of Cardiology, Angiology and Intensive Medical Care Jena University Hospital

    Jena, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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