Weight-Loss drug mounjaro could keep hearts in rhythm after ablation
NCT ID NCT07630454
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepatide injections plus standard care, or standard care alone, for 12 months. The main goal is to see if tirzepatide lowers the number of people who have another episode of irregular heartbeat.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tirzepatide (Mounjaro), a weekly injection for weight and blood sugar control
- What this could lead to
- If it works, this could point toward a new way to prevent atrial fibrillation from coming back after ablation in people with obesity and heart failure.
- What could go wrong
- This trial hasn't started yet, and it's open-label, which can bias results. Tirzepatide may cause side effects like nausea or vomiting, and the benefit for heart rhythm is not proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beijing Anzhen Hospital
Beijing, Beijing Municipality, 100029, China
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