New pacemaker approach could improve life for heart failure patients with AFib
NCT ID NCT07604727
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac resynchronization therapy. Researchers will track deaths, heart failure hospitalizations, and quality of life over three years to see if the newer pacing method is at least as good as the standard one.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Conduction system pacing or cardiac resynchronization therapy (both are procedures to implant a pacemaker)
What this could lead to
If it works, this could show that conduction system pacing is a better option than standard cardiac resynchronization for managing heart failure symptoms and improving quality of life in people with atrial fibrillation.
What could go wrong
This trial has not started recruiting yet, so results are years away. It is also a noninferiority study, meaning it aims to show one method is not worse than the other, not necessarily that it is better. Risks include complications from the ablation or pacemaker implantation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Antonius Hospital
Nieuwegein, Netherlands
Contact Email: •••••@•••••
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Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
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CHU de Grenoble
Grenoble, France
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CHU de Rouen
Rouen, France
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CHU la Timone
Marseille, France
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Clinique Pasteur Toulouse
Toulouse, France
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Department of Cardiology, IRCCS Instituto Auxologico Italiano, Ospedale San Luca
Milan, Italy
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Department of Cardiology, Ospedale Panico
Tricase, Italy
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Department of Cardiology, Ospedale S. Maria Nuova
Reggio Emilia, Italy
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Department of Cardiology, Ospedali del Tigullio
Lavagna, Italy
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FrisiusMC
Leeuwarden, Netherlands
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Hôpital Européen Georges Pompidou
Paris, France
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Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
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Klinik für Kardiologie und Intensivmedizin
Stade, Germany
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Klinikum rechts der Isar
München, Germany
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Maastricht UMC
Maastricht, Netherlands
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Marienhospital Gelsenkirchen
Gelsenkirchen, Germany
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Ospedale San Pietro Fatebenefratelli
Roma, Italy
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Ospedale San Raffaele
Milan, Italy
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Ospedale Santa Maria della Pieta
Nola, Italy
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St. Vincenz-Krankenhaus GmbH
Paderborn, Germany
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University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands
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Contact
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University Medical Center Mainz
Mainz, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••