Heart valve repair may unlock higher doses of key heart failure drugs

NCT ID NCT07578129

Not yet recruiting Knowledge-focused Sponsor: Ceric Sàrl Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of standard heart failure medications compared to before the procedure. Researchers will also track hospitalizations and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PASCAL Precision System (device for tricuspid valve repair)
What this could lead to: If successful, this could show that repairing the tricuspid valve helps heart failure patients tolerate higher doses of guideline-directed medications, potentially improving outcomes.
What could go wrong: This is a small, early observational study (50 people) with no control group. It only measures medication changes, not direct health improvements, so results may not be conclusive.

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Conditions

The condition(s) this trial relates to.

left ventricular failure tricuspid valve insufficiency Ventricular Dysfunction, Left

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEFT VENTRICULAR (LV) SYSTOLIC DYSFUNCTION LEFT VENTRICULAR CARDIAC DYSFUNCTION LEFT VENTRICULAR DYSFUNCTION LEFT VENTRICULAR EJECTION FRACTION TRICUSPID INSUFFICIENCY TRICUSPID REGURGITATION (TR)

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