Urine test could guide heart failure treatment and save lives

NCT ID NCT07558798

Not yet recruiting Disease control Sponsor: University Hospital, Akershus Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adjusting diuretic doses based on urine sodium levels improves outcomes for people hospitalized with acute heart failure and severe fluid buildup. About 270 participants will be randomly assigned to either standard care or a strategy where diuretic doses are doubled if urine sodium is low. The goal is to see if this approach reduces deaths, hospital readmissions, and length of stay.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: loop diuretics (e.g., furosemide)
What this could lead to: If successful, this approach could reduce deaths, hospital readmissions, and hospital stays for people with severe heart failure.
What could go wrong: This is a relatively small, early-stage study (270 participants) that has not yet started. The benefit may be modest or not apply to all patients, and the urine-sodium monitoring adds complexity to care.

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Conditions

The condition(s) this trial relates to.

heart failure Hyperemia VEXAS syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIURETICS HEART FAILURE, ACUTE VENOUS CONGESTION VEXUS

Contacts and locations

Locations

Akershus University Hospital

Lørenskog, Akershus, 1478, Norway
Østfold Hospital Trust

Sarpsborg, Østfold fylke, 1714, Norway

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