Can quick drug optimization after heart failure hospitalization save lives in women?

NCT ID NCT07295522

Not yet recruiting Disease control Sponsor: IRCCS Policlinico S. Donato Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimization) or usual care. Researchers will track deaths, hospital readmissions, and worsening heart failure over one year to see if the intensive approach is safer and more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Guideline-directed medical therapy (GDMT) including beta-blockers, ACE inhibitors, ARBs, ARNIs, mineralocorticoid receptor antagonists, and SGLT2 inhibitors
What this could lead to: If successful, this could show that a rapid, intensive medication strategy after heart failure hospitalization reduces deaths and readmissions, especially for women.
What could go wrong: This is a Phase 4 study with a moderate sample size, so results may not apply to all heart failure patients. The intensive drug regimen may cause side effects or be poorly tolerated in some women.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HEART FAILURE HEART FAILURE HEART FAILURE WITH MILDLY REDUCED EJECTION FRACTION HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)

Contacts and locations

Locations

Azienda Ospedaliero Universitaria Delle Marche

Ancona, Italy
Azienda Sanitaria Locale Bari

Bari, Italy
Azienda USL IRCCS Di Reggio Emilia

Reggio Emilia, Italy
Azienda USL Toscana Centro

Florence, Italy
Azienda USL Toscana Nord Ovest - Cecina

Cecina, Italy
Centro Cardiologico Monzino

Milan, Italy
Fondazione Policlinico Universitario Campus Bio-medico

Roma, Italy
Fondazione Toscana Gabriele Monasterio

Pisa, Italy
IRCCS Policlinico San Donato

San Donato Milanese, MILANO, 20097, Italy
Istituto Auxologico Italiano

Milan, Italy
Ospedale S. Maria delle Croci

Ravenna, Italy
Ospedale San Camillo Forlanini

Roma, Italy
Ospedale Universitario di Ferrara

Ferrara, Italy

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