Can quick drug optimization after heart failure hospitalization save lives in women?
NCT ID NCT07295522
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimization) or usual care. Researchers will track deaths, hospital readmissions, and worsening heart failure over one year to see if the intensive approach is safer and more effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Guideline-directed medical therapy (GDMT) including beta-blockers, ACE inhibitors, ARBs, ARNIs, mineralocorticoid receptor antagonists, and SGLT2 inhibitors
What this could lead to
If successful, this could show that a rapid, intensive medication strategy after heart failure hospitalization reduces deaths and readmissions, especially for women.
What could go wrong
This is a Phase 4 study with a moderate sample size, so results may not apply to all heart failure patients. The intensive drug regimen may cause side effects or be poorly tolerated in some women.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliero Universitaria Delle Marche
Ancona, Italy
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Azienda Sanitaria Locale Bari
Bari, Italy
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Azienda USL IRCCS Di Reggio Emilia
Reggio Emilia, Italy
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Azienda USL Toscana Centro
Florence, Italy
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Azienda USL Toscana Nord Ovest - Cecina
Cecina, Italy
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Centro Cardiologico Monzino
Milan, Italy
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Fondazione Policlinico Universitario Campus Bio-medico
Roma, Italy
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Fondazione Toscana Gabriele Monasterio
Pisa, Italy
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IRCCS Policlinico San Donato
San Donato Milanese, MILANO, 20097, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Istituto Auxologico Italiano
Milan, Italy
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Ospedale S. Maria delle Croci
Ravenna, Italy
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Ospedale San Camillo Forlanini
Roma, Italy
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Ospedale Universitario di Ferrara
Ferrara, Italy