ACUTE HEART FAILURE

This study tests whether the drug finerenone can reduce hospitalizations and deaths in people with a certain type of heart failure (with preserved or mildly reduced pumping ability). About 5,200 adults who are currently or recently hospitalized for heart failure will receive eith…

This study tests whether opening blood vessels (vasodilation) or removing fluid (diuretics) is better for treating sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath and low oxygen levels will receive one of three treatments i…

This study tests whether starting the drug finerenone early during a hospital stay for acute heart failure can improve outcomes. About 550 adults with heart failure and preserved ejection fraction will receive either finerenone or a placebo. Researchers will track deaths, worseni…

This study tests whether empagliflozin, a drug already used for diabetes, can help people hospitalized with acute heart failure. About 444 adults will receive either the drug or a placebo to see if it reduces deaths, hospital readmissions, and other serious events within 90 days.…

This study tests whether using lung ultrasound to guide fluid removal in adults hospitalized for acute heart failure leads to better outcomes than standard physical exams. Researchers will compare how long patients stay alive and out of the hospital over 40 days, as well as sympt…

This study tests whether MRI can accurately measure fluid buildup in the lungs of people hospitalized for acute heart failure. Researchers will track 300 patients from admission to discharge to see how lung water changes with treatment and whether these measurements can predict w…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study observes 270 adults hospitalized with acute heart failure to identify different patterns of fluid buildup (congestion). Researchers will use ultrasound, liver scans, and urine tests to see how these patterns relate to treatment response and outcomes like rehospitalizat…