ACUTE HEART FAILURE
Clinical trials for ACUTE HEART FAILURE explained in plain language.
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Hospital heart pill may prevent repeat crises
Disease control CompletedThis study tested whether starting the drug dapagliflozin during a hospital stay for acute heart failure can reduce the risk of death or worsening heart failure. Over 2,400 adults who were stable after initial treatment were randomly given either dapagliflozin or a placebo. The g…
Matched conditions: ACUTE HEART FAILURE
Phase: PHASE4 • Sponsor: The TIMI Study Group • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Oxygen showdown: tight vs. liberal targets in heart failure
Disease control CompletedThis study tested whether giving heart failure patients with fluid in their lungs a lower oxygen target (90% oxygen saturation) or a higher one (96%) leads to better outcomes. 122 patients were randomly assigned to one of the two groups in the emergency department. The goal was t…
Matched conditions: ACUTE HEART FAILURE
Phase: PHASE2, PHASE3 • Sponsor: Copenhagen University Hospital, Hvidovre • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New diuretic protocol aims to improve heart failure treatment safety
Disease control CompletedThis study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…
Matched conditions: ACUTE HEART FAILURE
Phase: PHASE4 • Sponsor: University Hospital, Clermont-Ferrand • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Can a diabetes pill help heart failure patients get rid of excess fluid?
Symptom relief CompletedThis study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…
Matched conditions: ACUTE HEART FAILURE
Phase: PHASE4 • Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Could a week of steroids help heart failure patients in the ER?
Symptom relief CompletedThis study tested whether a 7-day course of prednisone, started in the emergency department, can lower inflammation (measured by C-reactive protein) in patients with acute heart failure. Only 3 people took part, and the main goal was to see how CRP levels changed. The researchers…
Matched conditions: ACUTE HEART FAILURE
Phase: PHASE2, PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Vein-Blocking device shows promise for heart failure patients
Symptom relief CompletedThis study tested a device called preCARDIA that temporarily blocks a large vein in the chest to help patients with sudden, severe heart failure. The goal was to see if it is safe and can help remove excess fluid when standard treatments are not working. The study included 60 adu…
Matched conditions: ACUTE HEART FAILURE
Phase: NA • Sponsor: Abiomed Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Steroid short course may cool inflammation in heart failure
Symptom relief CompletedThis study tested whether a 7-day course of prednisone, a steroid, can lower inflammation in people with acute heart failure. 101 emergency department patients were randomly assigned to get either standard care or standard care plus prednisone. The main goal was to see if CRP, a …
Matched conditions: ACUTE HEART FAILURE
Phase: NA • Sponsor: Heart Initiative • Aim: Symptom relief
Last updated Jun 26, 2026 17:25 UTC
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Blood marker may reveal kidney trouble early in heart failure patients
Knowledge-focused CompletedThis study looked at 64 adults hospitalized for acute heart failure to see if a blood marker called cystatin C could detect early kidney problems caused by diuretic treatment. Researchers measured cystatin C levels daily and compared them to standard kidney tests. The goal was to…
Matched conditions: ACUTE HEART FAILURE
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC