Oxygen showdown: tight vs. liberal targets in heart failure

NCT ID NCT05613218

Completed Disease control Sponsor: Copenhagen University Hospital, Hvidovre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving heart failure patients with fluid in their lungs a lower oxygen target (90% oxygen saturation) or a higher one (96%) leads to better outcomes. 122 patients were randomly assigned to one of the two groups in the emergency department. The goal was to see which oxygen level reduces fluid in the lungs and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oxygen
What this could lead to: If it works, this could help doctors choose the best oxygen level for heart failure patients, potentially improving recovery and reducing hospital stays.
What could go wrong: This is a small pilot study with only 122 patients, so results may not apply to everyone. The oxygen targets are narrow, and the study may not find a clear benefit or harm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure Hypoxia pulmonary edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HEART FAILURE HYPOXEMIA PULMONARY CONGESTION

Contacts and locations

Locations

Amager-Hvidovre Hospital

Copenhagen, 2650, Denmark
Bispebjerg Hospital

Copenhagen, 2200, Denmark

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