New diuretic protocol aims to improve heart failure treatment safety
NCT ID NCT03892148
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiazide against standard non-protocolized practice. Researchers measured changes in kidney function and weight to see if the protocol reduced complications like kidney injury.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Furosemide and hydrochlorothiazide (diuretics)
What this could lead to
If successful, this could establish a safer, more effective way to manage fluid buildup in chronic heart failure patients, reducing hospital stays and kidney damage.
What could go wrong
This is a completed Phase 4 trial with 299 participants, but the protocol may not work for all patients or settings. Risks include kidney injury and electrolyte imbalances.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CH PUY
Le Puy-en-Velay, France
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CH RIOM
Riom, France
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CHU de GRENOBLE
Grenoble, France
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Ch Annecy
Annecy, France
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Ch Issoire
Issoire, France
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Ch Lyon Sud
Lyon, France
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Ch Moulins
Moulins, France
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Chu Clermont-Ferrand
Clermont-Ferrand, 63003, France
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Infirmerie Protestante de Lyon
Lyon, 69300, France