New diuretic protocol aims to improve heart failure treatment safety

NCT ID NCT03892148

Completed Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiazide against standard non-protocolized practice. Researchers measured changes in kidney function and weight to see if the protocol reduced complications like kidney injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Furosemide and hydrochlorothiazide (diuretics)
What this could lead to: If successful, this could establish a safer, more effective way to manage fluid buildup in chronic heart failure patients, reducing hospital stays and kidney damage.
What could go wrong: This is a completed Phase 4 trial with 299 participants, but the protocol may not work for all patients or settings. Risks include kidney injury and electrolyte imbalances.

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HEART FAILURE CHRONIC HEART FAILURE HEART FAILURE

Contacts and locations

Locations

CH PUY

Le Puy-en-Velay, France
CH RIOM

Riom, France
CHU de GRENOBLE

Grenoble, France
Ch Annecy

Annecy, France
Ch Issoire

Issoire, France
Ch Lyon Sud

Lyon, France
Ch Moulins

Moulins, France
Chu Clermont-Ferrand

Clermont-Ferrand, 63003, France
Infirmerie Protestante de Lyon

Lyon, 69300, France

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