CHRONIC HEART FAILURE

This study tests a device that automatically measures foot swelling in people with chronic heart failure. The device sends alerts to healthcare teams if swelling increases, which could signal worsening heart failure. About 1,500 participants will use the device at home for at lea…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study tests whether taking selenium and coenzyme Q10 (CoQ10) supplements can reduce heart failure-related hospital visits and deaths. About 1,100 adults with chronic heart failure will receive either the supplements or a placebo alongside their usual care. The goal is to see…

This study tests a new heart pacing method (LOT-CRT) against the standard one (BiVP) in 86 heart failure patients with a specific type of heart block. The goal is to see if the new method better preserves heart pumping function. Participants will be followed for at least 6 months…

This study tests whether replacing unhealthy gut bacteria with healthy donor bacteria (via capsules) is safe and doable for people with chronic heart failure. About 40 adults with stable heart failure will take the capsules and be monitored for side effects and adherence. The goa…

This study follows 30 children aged 1 to 17 with chronic heart failure who are taking Entresto for the first time. Researchers will monitor for side effects like low blood pressure, high potassium, kidney problems, and dehydration over 52 weeks. The goal is to understand how safe…

This study tests whether a home-based cardiac rehabilitation program using wearable devices and remote monitoring can improve exercise capacity in adults with chronic heart failure. Researchers will compare the home program to standard in-hospital rehab. The goal is to see if the…

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. The trial will include 360 adults who have a new, persistent heart block…

This study looks at whether the drug vericiguat can help repair the hearts of adults with stable heart failure with reduced ejection fraction (HFrEF). Researchers will compare people taking vericiguat plus standard care to those on standard care alone, measuring changes in heart …

This study is testing a wearable system called Sensinel CPM to see if it can help people with chronic heart failure avoid hospital visits and reduce healthcare costs. About 1200 participants with moderate to severe heart failure will use the device, and their results will be comp…

This study tests whether injecting stem cells from umbilical cords into the heart during bypass surgery can help repair heart muscle and improve function in people with chronic heart failure. About 51 adults with weak hearts (ejection fraction 40% or less) will take part. The goa…

This study will compare two groups of people with chronic heart failure: those who receive the Cordella PA Sensor System (an implanted device that monitors pressure in the lung artery) and those who get standard medication alone. Researchers will track about 2,150 participants fo…

This phase 2 trial at Yale University is testing whether the diabetes drug ertugliflozin can help people with chronic heart failure manage fluid buildup better than a standard diuretic (metolazone) or a placebo. Sixty adults on daily diuretics will take one of the three treatment…

This study tests whether a daily oral iron supplement (sucrosomial iron with vitamin C) can improve exercise ability and quality of life in people with chronic heart failure and iron deficiency. About 60 participants will receive either the iron supplement or a placebo for 24 wee…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study looks at whether giving intravenous iron (Ferinject) to heart failure patients with low iron can improve their quality of life and walking ability. About 100 hospitalized adults with a specific type of heart failure (HFpEF) will receive either iron infusions plus diet …

This study tests whether a mobile-based telemedicine program—using phone calls and text messages for health education, medication reminders, and lifestyle advice—can improve quality of life in adults with chronic heart failure. About 70 patients in Ethiopia will be split into two…

This study tests whether an 8-week machine-based resistance training program can improve muscle strength and physical function in older adults (60+) who have both chronic heart failure and sarcopenia (age-related muscle loss). Researchers will measure handgrip strength and sit-to…

This study tests whether high-flow oxygen therapy can improve heart function in people with chronic heart failure who have recently had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine) in 30 adults. The goal is to see if the oxygen ther…

This study tests a 12-week home-based tai chi program for people with chronic heart failure and their caregivers. Participants learn tai chi through videos and online coaching, aiming to improve heart function and reduce caregiver burden. The trial enrolls 256 sedentary adults wi…

This study is testing whether using mobile health apps and receiving tailored text messages can help people with chronic heart failure take better care of themselves and avoid hospital stays. Researchers will enroll 360 adults with Stage C heart failure and randomly assign them t…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study looks at whether shorter or longer sessions of high-intensity interval training (HIIT) work better for people with chronic heart failure. Researchers will measure changes in walking ability, heart function, and quality of life in 45 participants. The goal is to find a …

This study tests whether combining cognitive training (brain games) with physical exercise can improve thinking, memory, and brain blood flow in people with chronic heart failure. Researchers will enroll 216 men and women aged 50 and older with stable heart failure. Participants …

This study tests whether nurse-led education for heart failure patients and their informal caregivers can improve patients' quality of life, self-care, and medication adherence. About 280 patients recently hospitalized for heart failure and their caregivers will receive oral sess…

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study is testing a skin patch called MyHeartSentinel that records heart electrical and mechanical signals in people with heart failure. Researchers want to see if the patch can detect early signs of a worsening episode (decompensation) while patients are in the hospital and …

This study follows 1,400 Japanese adults with chronic heart failure to see how safe the drug vericiguat is in everyday use. Half will take vericiguat plus standard care, the other half standard care alone. Researchers will track side effects, blood pressure, and heart-related dea…

This study follows 1,000 adults with chronic heart failure to learn what factors influence their health outcomes, such as heart-related death or unplanned hospital visits. Researchers will collect data on genetics, gut bacteria, environment, and other markers. The goal is to bett…

This study is collecting information from 20,000 people with chronic heart failure in Russia to understand how they are diagnosed, treated, and monitored. Researchers will look at patient ages, treatments, and hospital visits. The goal is to find gaps in care and improve future t…

This study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…

This study follows 2,000 people with chronic heart failure to see how their physical activity levels relate to hospitalizations and survival. Participants wear a pedometer or smartwatch and answer activity questionnaires every six months. No new treatment is given—the goal is sim…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 participants over time, using heart scans and blood tests to see if certain biomarkers can spot trouble before symptoms …

This study tests a special MRI that can show how heart cells process energy in people with ischemic heart disease. About 15 adults with chronic heart failure will get this scan along with standard tests. The goal is to see if this new method can tell healthy from damaged heart ti…

This study looks at whether certain proteins in the blood can predict if someone with chronic heart failure will develop kidney problems (cardiorenal syndrome). Researchers will measure these proteins in 150 adults with heart failure and follow them for one year. The goal is to f…

This study observes 300 adults in South Korea with chronic heart failure who are prescribed finerenone as part of their usual care. Researchers will track side effects and treatment satisfaction over one year. The goal is to see how safe and effective finerenone is in everyday me…

This study is creating a registry of 101 adults with chronic heart failure to track their health over time. Researchers will collect data on disease progression and survival at one, five, and ten years after diagnosis. The goal is to better understand how heart failure evolves, n…

This pilot study is testing whether wearable devices like smartwatches, blood pressure monitors, and smart scales can help patients recover after a stay in the intensive care unit (ICU). Many ICU survivors face physical and mental challenges, known as Post-Intensive Care Syndrome…