CHRONIC HEART FAILURE

This study looks at whether a special pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after a minimally invasive aortic valve replacement (TAVI). About 360 participants will be randomly assigned to get the pa…

This study looks at whether the drug vericiguat can improve heart function in adults with stable heart failure with reduced ejection fraction (HFrEF). About 60 participants will either take vericiguat plus their usual medications or just their usual medications. Researchers will …

This study looks at whether combining physical exercise with cognitive training (like brain games) can improve thinking and memory in people with chronic heart failure. Researchers will also see if the effects differ between men and women. About 216 adults aged 50 and older with …

This study looks at whether giving iron through a vein (Ferinject®) can improve quality of life and walking ability in people with a type of heart failure called HFpEF who also have low iron. About 100 hospitalized adults will receive either iron or standard care. The goal is to …

This study tests whether injecting stem cells from donated umbilical cords into the heart muscle during bypass surgery can help people with chronic heart failure. About 51 adults with weak hearts (ejection fraction 40% or less) will receive the stem cells or a placebo. The goal i…

This study tests a device that automatically tracks leg swelling (edema) in people with chronic heart failure. The goal is to see if early alerts from the device can help doctors adjust treatment and reduce hospital stays. About 1,500 adults with a history of leg swelling will us…

This study tests whether replacing unhealthy gut bacteria with healthy donor bacteria (called intestinal microbiota transplantation) is safe and possible for people with chronic heart failure. About 40 adults with heart failure will take capsules containing donor bacteria. The go…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps the heart keep pumping blood during the procedure. Researchers will track deaths, heart attacks, and strokes for one year to see…

This study looks at whether an 8-week machine-based resistance training program can improve muscle strength and physical function in older adults (60+) who have both chronic heart failure and sarcopenia (age-related muscle loss). About 146 participants will be randomly assigned t…

This study tests whether a special oral iron supplement (sucrosomial iron) can improve exercise ability and quality of life in people with chronic heart failure who also have low iron levels. About 60 participants will receive either the iron supplement or a placebo for several w…

This study tests whether regular yoga practice can improve quality of life and reduce anxiety and depression in adults with stable chronic heart failure. Researchers will enroll 66 participants who will practice yoga alongside their usual medical care. The goal is to see if yoga …

This study looks at whether low or high volume high-intensity interval training is better for people with chronic heart failure. It aims to improve how well they can move and their quality of life. The study will include 45 adults with stable heart failure and reduced pumping abi…

This study looks at the safety of finerenone, a drug already approved for chronic heart failure, in 300 adults in South Korea. Participants take the drug as prescribed by their doctor, and researchers collect data from routine care for one year. The goal is to see how safe and ef…

This study will collect information from 20,000 people with chronic heart failure in Russia to understand how they are diagnosed, treated, and monitored. Researchers will look at which medicines are used and how patients are doing. The goal is to find ways to improve heart failur…

This study is looking for early warning signs of heart failure in 500 people with type 2 diabetes who are over 50. Participants will have blood tests and heart scans to see if certain markers can predict heart problems. The goal is to find better ways to catch heart failure early…

This study looks at whether high-flow oxygen therapy can lower pressure in the heart's blood vessels for people with chronic heart failure who have just had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine). The goal is to understand how…

This study looks at the safety of a drug called vericiguat in Japanese people with chronic heart failure. Researchers will track side effects and see how long the drug can prevent heart-related deaths compared to standard care. About 1400 participants will be followed for up to 2…

This study is testing whether a special wearable device, guided by artificial intelligence, can help adults with chronic heart failure avoid emergency visits and hospital stays. About 205 participants will either wear the device for six months or receive standard care. The goal i…