CHRONIC HEART FAILURE

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested a new drug called JTT-861 in 314 adults with chronic heart failure and reduced pumping ability. Participants took either the drug or a placebo once daily for 12 weeks, alongside their usual heart medications. The goal was to see if the drug improves heart functi…

This completed study monitored 1200 Japanese patients with chronic heart failure who were prescribed JARDIANCE® (empagliflozin) for the first time. Researchers tracked side effects, deaths, and hospitalizations over the long term to see how the drug performs in everyday use. The …

This study tested a single injection of special stem cells (Rexlemestrocel-L) into the heart for people with chronic heart failure. The goal was to see if it could reduce serious heart events like hospitalizations or death. The trial involved 565 adults and compared the stem cell…

This completed study tested a device that uses ultrasound to calm overactive nerves near the kidneys (renal denervation) in 6 people with chronic heart failure. The goal was to see if it is safe and can improve heart function by reducing sympathetic nerve activity. Because it was…

This study tested a new medicine called AZD5462 in 375 adults with stable chronic heart failure. The goal was to see if the drug could improve how well the heart pumps blood. Participants continued their usual heart failure medications while receiving either AZD5462 or a placebo.…

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…

This study tested a remote monitoring system called Seerlinq HeartCore in 330 heart failure patients. Participants used a device at home to measure heart function and report symptoms. The goal was to see if this approach could reduce hospitalizations and deaths over 6 months. The…

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This study tested whether a home-based exercise program is practical for people with chronic heart failure who have just been hospitalized. Thirty patients were taught exercises by a physiotherapist and did them at home for 12 weeks. The goal was to see how many completed the pro…

This study looked at whether doing resistance or aerobic exercise first during a rehab session affects heart function in men with chronic heart failure. Sixty men aged 55-65 with reduced heart pumping ability took part. Researchers measured heart function and quality of life to s…

This study tested whether acupuncture can improve heart function and quality of life in people with chronic heart failure. Fourteen patients received 10 acupuncture sessions over 5 weeks, and each person also served as their own control with a no-treatment period. Researchers mea…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This study looked at a new way of managing chronic heart failure using nurse-led consultations. Researchers reviewed the records of 138 patients to understand how these consultations helped with adjusting medications and monitoring health. The goal was to see if this approach can…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This completed study looked at 26,000 adults with chronic heart failure in France who used a web app for remote monitoring. Researchers compared those who were digitally literate with those who were not, tracking hospitalizations and death rates. The goal was to understand whethe…

This study looked at how common vitamin D deficiency is in people with chronic heart failure and whether giving vitamin D supplements improves their health. 91 adults with heart failure were divided into groups based on their vitamin D levels. Those with severe deficiency were ra…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…