Could a heart pill boost exercise capacity in chronic heart failure?
NCT ID NCT07697365
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study looks at whether vericiguat, a drug that stimulates a key enzyme, can improve exercise ability and heart pressure during activity in people with chronic heart failure and reduced ejection fraction. Participants take vericiguat alongside their usual heart medications and undergo exercise tests and heart catheterization at the start and after 12 months. The goal is to see if the drug helps the heart handle exercise better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vericiguat
- What this could lead to
- If vericiguat improves exercise tolerance and heart pressures during activity, it could become a standard add-on treatment for heart failure patients already on other therapies.
- What could go wrong
- This is a small observational study with only 40 participants, so results may not apply to all heart failure patients. Vericiguat may cause low blood pressure or other side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alexandra General Hospital
Athens, Attica, 11528, Greece
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