Zapping nerves with ultrasound: a new hope for heart failure?
NCT ID NCT04719637
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study tested a device that uses ultrasound to calm overactive nerves near the kidneys (renal denervation) in 6 people with chronic heart failure. The goal was to see if it is safe and can improve heart function by reducing sympathetic nerve activity. Because it was a very small early study, the results are only a first step and need confirmation in larger trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ultrasound renal denervation device (PRDS-001)
What this could lead to
If successful, this approach could offer a new way to manage heart failure by calming overactive nerves, potentially reducing symptoms and improving heart function.
What could go wrong
This was a very small early study (only 6 patients) with no control group, so results are preliminary. The procedure carries risks like blood vessel damage, and it is unclear if benefits will hold in larger trials.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Osaka University Hospital
Osaka, Japan