Zapping nerves with ultrasound: a new hope for heart failure?

NCT ID NCT04719637

Completed Disease control Sponsor: Otsuka Medical Devices Co., Ltd. Japan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested a device that uses ultrasound to calm overactive nerves near the kidneys (renal denervation) in 6 people with chronic heart failure. The goal was to see if it is safe and can improve heart function by reducing sympathetic nerve activity. Because it was a very small early study, the results are only a first step and need confirmation in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultrasound renal denervation device (PRDS-001)
What this could lead to: If successful, this approach could offer a new way to manage heart failure by calming overactive nerves, potentially reducing symptoms and improving heart function.
What could go wrong: This was a very small early study (only 6 patients) with no control group, so results are preliminary. The procedure carries risks like blood vessel damage, and it is unclear if benefits will hold in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder congestive heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEART FAILURE

Contacts and locations

Locations

Osaka University Hospital

Osaka, Japan

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