Could a smarter pacemaker ease a common type of heart failure?

NCT ID NCT06678841

Recruiting now Disease control Sponsor: Medtronic Cardiac Rhythm and Heart Failure Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This study tests whether a pacemaker programmed to each person's needs can improve symptoms and outcomes for people with a common type of heart failure (HFpEF). About 700 adults with heart failure but normal pumping strength will receive either personalized pacing or minimal/no pacing. The goal is to see if this approach reduces heart-related deaths, hospitalizations, and improves quality of life.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder diastolic heart failure heart disorder heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Contacts and locations

Locations

Banner - University Medical Center Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
CHU Toulouse - Hôpital Rangueil
RECRUITING

Toulouse, 50032, France
Cardiovascular Institute of Northwest Florida
RECRUITING

Panama City, Florida, 32405, United States
Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
Centre Hospitalier Universitaire Besancon - Hôpital Jean Minjoz
RECRUITING

Besançon, 25030, France
Centre Hospitalier Universitaire de Clermont-Ferrand - Gabriel-Montpied
RECRUITING

Clermont-Ferrand, 63003, France
Charleston Area Medical Center (CAMC) Memorial Hospital
RECRUITING

Charleston, West Virginia, 25304, United States
Chiba University Hospital
RECRUITING

Chiba, Chiba, 260-8677, Japan
Dallas VA Medical Center
RECRUITING

Dallas, Texas, 75216, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Fakultni nemocnice Královské Vinohrady
RECRUITING

Prague, 100 34, Czechia
Froedtert Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Guys and St. Thomas NHS Foundation Trust - St. Thomas Hospital
RECRUITING

London, SE1 7EH, United Kingdom
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Hôpitaux Universitaires de Genève
RECRUITING

Geneva, 1205, Switzerland
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Institut Jantung Negara - National Heart Institute
RECRUITING

Kuala Lumpur, 50400, Malaysia
Kokura Memorial Hospital
RECRUITING

Kitakyushu, Fukuoka, 802-8555, Japan
Lancaster General Hospital
RECRUITING

Lancaster, Pennsylvania, 17602, United States
Lankenau Institute for Medical Research
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
M Health Fairview University of Minnesota Medical Center - East Bank
RECRUITING

Minneapolis, Minnesota, 55455, United States
Manchester University NHS Foundation Trust - Manchester Royal Infirmary
RECRUITING

Manchester, M13 9WL, United Kingdom
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Mount Carmel East
RECRUITING

Columbus, Ohio, 43219, United States
National Cerebral and Cardiovascular Center
RECRUITING

Suita, Osaka, 564-8565, Japan
Norton Healthcare
RECRUITING

Louisville, Kentucky, 40295, United States
Ordensklinikum Linz GmbH / Elisabethinen
RECRUITING

Linz, 4010, Austria
Oslo Universitetssykehus-Rikshospitalet
RECRUITING

Oslo, 0372, Norway
Prince of Wales Hospital
RECRUITING

Hong Kong, Hong Kong
Queen Elizabeth Hospital (Hong Kong)
RECRUITING

Hong Kong, Hong Kong
Saint Joseph Medical Center (Tacoma WA)
RECRUITING

Tacoma, Washington, 98405, United States
Saint Lukes Mid America Heart Institute
RECRUITING

Kansas City, Missouri, 64111, United States
Saint Pauls Hospital
RECRUITING

Vancouver, V6Z 1Y6, Canada
Saint Thomas Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sarawak Heart Centre
RECRUITING

Kota Samarahan, 94300, Malaysia
Sutter Health Hospital
RECRUITING

San Francisco, California, 94107, United States
Texas Health Research & Education Institute
RECRUITING

Fort Worth, Texas, 76104, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Leeds Teaching Hospitals NHS Trust - Leeds General Infirmary
RECRUITING

Leeds, LS1 3EX, United Kingdom
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The Prince Charles Hospital
RECRUITING

Chermside, Queensland, 4032, Australia
The University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
The University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
University Medical Centre Ljubljana
RECRUITING

Ljubljana, 1000, Slovenia
University of Calgary
RECRUITING

Calgary, T2N 2T9, Canada
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
RECRUITING

Lübeck, 23538, Germany

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