Can a Two-Drug punch early in hospitalization tame heart failure?
NCT ID NCT06024746
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 3 trial investigates whether starting a combination of finerenone and empagliflozin early during a hospital stay for heart failure can improve outcomes compared to usual care. About 1,500 adults hospitalized with heart failure will be enrolled. The study measures effects on survival, heart failure events, symptoms, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of finerenone and empagliflozin
- What this could lead to
- If successful, this could establish a new standard early-combination therapy for hospitalized heart failure patients, potentially reducing deaths and hospital readmissions.
- What could go wrong
- This is a phase 3 trial, but combination therapy may increase side effects or drug interactions. Results may not apply to all heart failure types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CON-10001, Aurora, CO
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CON-10002 Kansas City, MO Investigative Site
RECRUITINGKansas City, Missouri, 64111, United States
Contact
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CON-10004 Fairhope, AL Investigational Site
RECRUITINGFairhope, Alabama, 36532, United States
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CON-10005, Denver, CO
RECRUITINGDenver, Colorado, 80204, United States
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CON-10009, Norfolk, VA
RECRUITINGNorfolk, Virginia, 23507, United States
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CON-10015 Austin, TX Investigational Site
RECRUITINGAustin, Texas, 78705, United States
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CON-10018, Omaha, NE
RECRUITINGOmaha, Nebraska, 68105, United States
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CON-10019, Peoria, IL
RECRUITINGPeoria, Illinois, 61603, United States
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CON-10021, Glenview, IL
RECRUITINGGlenview, Illinois, 60026, United States
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CON-10022 Atlanta, GA Investigational Site
RECRUITINGAtlanta, Georgia, 30303, United States
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CON-10023, San Francisco, CA
RECRUITINGSan Francisco, California, 94118, United States
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CON-10024 Sacramento, CA Investigational Site
RECRUITINGSacramento, California, 95816, United States
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CON-10025, Naperville, IL
RECRUITINGNaperville, Illinois, 60540, United States
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CON-10030 Baton Rouge, LA Investigational Site
RECRUITINGBaton Rouge, Louisiana, 70808, United States
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CON-10041, Island Lake, IL
RECRUITINGIsland Lake, Illinois, 60042, United States
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CON-10045 Amarillo, TX Investigational Site
RECRUITINGAmarillo, Texas, 79106, United States
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CON-10051, Chattanooga, TN
RECRUITINGChattanooga, Tennessee, 37403, United States
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CON-10064, Merrillville, IN
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CON-10075 El Centro, CA Investigational Site
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CON-10078, Hialeah, FL
RECRUITINGHialeah, Florida, 33012, United States
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CON-10079, Paducah, KY
RECRUITINGPaducah, Kentucky, 42003, United States
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CON-10080, Lexington, KY
RECRUITINGLexington, Kentucky, 40503, United States
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CON-10085, Houston, TX
RECRUITINGHouston, Texas, 77030, United States
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CON-10086, Louisville, Kentucky
RECRUITINGLouisville, Kentucky, 40205, United States
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CON-10090, West Monroe, LA
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CON-10105, Miami, FL
RECRUITINGMiami, Florida, 33135, United States
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CON-10109, Van Nuys, CA
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CON-10113, Miramar, FL
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CON-10119, Centerville, OH
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CON-10301, Fort Worth, TX
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CON-10304, Denison, TX
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CON-10305, Layton, UT
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CON-10318, Charlotte, NC
RECRUITINGCharlotte, North Carolina, 28207, United States
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CON-11001, Toronto, ON
RECRUITINGToronto, Ontario, M5G 2C4, Canada
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CON-11005 Sherbrooke, QC Investigational Site
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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CON-11007 North York, ON Investigational Site
RECRUITINGNorth York, Ontario, M6B 3H7, Canada
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CON-11008, Toronto, ON
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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CON-11010, London, ON
RECRUITINGLondon, Ontario, N6A 5A5, Canada
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CON-11011, Edmonton, AB
RECRUITINGEdmonton, Alberta, T6G 2B7, Canada
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CON-11012 Surry, BC Investigational Site
RECRUITINGSurrey, British Columbia, V3V OC6, Canada
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CON-11016, Sudbury, ON
RECRUITINGGreater Sudbury, Ontario, P3E 5J1, Canada
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CON-11019, Toronto, ON
RECRUITINGToronto, Ontario, M5B 1W8, Canada
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CON-11026, Montreal, Quebec
RECRUITINGMontreal, Quebec, H2X 1R9, Canada
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CON-21001, Recife, Recife
RECRUITINGRecife, Recife, 50720-110, Brazil
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CON-21003 Goiania, Goias Investigational Site
RECRUITINGGoiânia, Goiás, 74453-200, Brazil
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CON-21004 Braganca Paulista, Sao Paulo Investigational Site
RECRUITINGBragança Paulista, São Paulo, 12916542, Brazil
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CON-21005, Itaquera, São Paulo
RECRUITINGItaquera, São Paulo, 08270-120, Brazil
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CON-21007 Joinville, Santa Catarina Investigational Site
RECRUITINGJoinville, Santa Catarina, 89200-000, Brazil
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CON-21008, Caxias do Sul, Rio Grande do Sul
RECRUITINGCaxias do Sul, Rio Grande do Sul, 95070560, Brazil
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CON-21009, Poços de Caldas, Minas Gerais
RECRUITINGPoços de Caldas, Minas Gerais, 37706, Brazil
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CON-21010, Osasco, São Paulo
RECRUITINGOsasco, São Paulo, 06013-070, Brazil
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CON-21011, Presidente Prudente, São Paulo
RECRUITINGPresidente Prudente, São Paulo, 19050-680, Brazil
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CON-21013, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30441-070, Brazil
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CON-21014, Rio de Janeiro, Rio de Janeiro
RECRUITINGRio de Janeiro, Rio de Janeiro, 22240-006, Brazil
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CON-21016, Rio De Janeiro, Rio De Janeiro
RECRUITINGRio de Janeiro, Rio de Janeiro, 20551-030, Brazil
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CON-21017, Linhares, Espirito Santo
RECRUITINGLinhares, Espírito Santo, 29900-010, Brazil
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CON-21020, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30180-080, Brazil
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CON-21024, Natal, Rio Grande do Norte
RECRUITINGNatal, Rio Grande do Norte, 59020-500, Brazil
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CON-21028, Brasilia, Distrito Federal
RECRUITINGBrasília, Federal District, 70390-700, Brazil
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CON-21031, Votuporanga, São Paulo
RECRUITINGVotuporanga, São Paulo, 15505-189, Brazil
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CON-21032, Salvador, Bahia
RECRUITINGSalvador, Estado de Bahia, 40050-410, Brazil
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CON-21036, Rio Branco, Acre
RECRUITINGRio Branco, Acre, 69915-030, Brazil
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CON-21037, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 01323-001, Brazil
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CON-21038, Curitiba, Paraná
RECRUITINGCuritiba, Paraná, 80230-130, Brazil
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CON-21042, Passo Fundo, Rio Grande do Sul
RECRUITINGPasso Fundo, Rio Grande do Sul, 99010, Brazil
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CON-21047, Londrina, Paraná
RECRUITINGLondrina, Paraná, 86038, Brazil
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CON-21048, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 04004-30, Brazil
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CON-21049 Sao Paulo, Sao Paulo Investigational Site
RECRUITINGSão Paulo, São Paulo, 05652-900, Brazil
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CON-21051, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30220-140, Brazil
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CON-21053, Aparecida de Goiânia, Goias
RECRUITINGAparecida de Goiânia, Goiás, 74936-600, Brazil
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CON-21056, Curitiba, Paraná
RECRUITINGCuritiba, Paraná, 80060-900, Brazil
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CON-21057, Atibaia, São Paulo
RECRUITINGAtibaia, São Paulo, 12944-060, Brazil
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CON-21058, Aracaju, Sergipe
RECRUITINGAracaju, Sergipe, 49055-210, Brazil
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CON-21062, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 01317-002, Brazil
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CON-21064, Arapiraca, Alagoas, Brazil
RECRUITINGArapiraca, Alagoas, 57315-745, Brazil
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CON-21074, São Paulo, São Paulo
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CON-38001, Valencia, Valencia
RECRUITINGValencia, Valencia, 46010, Spain
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CON-38002, Madrid, Madrid
RECRUITINGMadrid, Madrid, 28034, Spain
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CON-38008, Santiago de Compostela, Galicia
RECRUITINGSantiago de Compostela, Galicia, 15706, Spain
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CON-38009, Manises, Valencia
RECRUITINGManises, Valencia, 46940, Spain
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CON-38011, Madrid, Madrid
RECRUITINGMadrid, Madrid, 28046, Spain
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CON-38012, Malaga, Malaga
RECRUITINGMálaga, Malaga, 29010, Spain
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CON-39001, Glasgow, UK
RECRUITINGGlasgow, G4 0SF, United Kingdom
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CON-39002, London, UK
RECRUITINGLondon, UK, SW17 0QT, United Kingdom
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CON-39007, Bristol, UK
RECRUITINGBristol, BS10 5NB, United Kingdom
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CON-39010, Bournemouth, Dorset
RECRUITINGBournemouth, Dorset, BH7 7DW, United Kingdom
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CON-51006, Ahmedabad, Gujarat
RECRUITINGAhmedabad, Gujarat, 380005, India
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CON-51009, Nagpur, Maharashtra
RECRUITINGNagpur, Maharashtra, 440033, India
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CON-51013, Bangalore, Karnataka
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CON-54001, Kandy, Central Province
RECRUITINGKandy, Central Province, 2000, Sri Lanka
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CON-54005, Colombo, Western Province
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CON-54007, Colombo, Western Province
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CON-54008, Ragama, Western Province
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CON-56001, Shanghai, Shanghai
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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CON-56002, Guangzhou, Guangdong province
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CON-56003, Tianjin, Tianjin
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CON-56004, Jinan, Shandong Province
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CON-56005, Taiyuan, Shanxi province
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CON-56006, Xi'an city, Shanxi Province
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CON-56007, Chengdu City, Sichuan Province
RECRUITINGChengdu, Sichuan, 610072, China
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CON-56008, Changsha, Hunan
RECRUITINGChangsha, Hunan, 410011, China
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CON-56009, Shanghai, Shanghai
RECRUITINGShanghai, Shanghai Municipality, 200120, China
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CON-56010, Hangzhou, Zhejiang Province
RECRUITINGHangzhou, Zhejiang, 311200, China
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CON021043, Santo André, São Paulo
RECRUITINGSanto André, São Paulo, 09090-790, Brazil
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