Can a Two-Drug punch early in hospitalization tame heart failure?
NCT ID NCT06024746
First seen Jul 23, 2026 · Last updated Sep 11, 2026 · Updated 3 times
Summary
This phase 3 trial investigates whether starting a combination of finerenone and empagliflozin early during a hospital stay for heart failure can improve outcomes compared to usual care. About 1,500 adults hospitalized with heart failure will be enrolled. The study measures effects on survival, heart failure events, symptoms, and safety.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a combination of finerenone and empagliflozin
- What this could lead to
- If successful, this could establish a new standard early-combination therapy for hospitalized heart failure patients, potentially reducing deaths and hospital readmissions.
- What could go wrong
- This is a phase 3 trial, but combination therapy may increase side effects or drug interactions. Results may not apply to all heart failure types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Provide electronic or written informed consent, either personally or through a legally authorized representative, as permitted by local regulations * Age ≥18 years or legal age of majority if \>18 years in the participant's country of residence * Current hospitalization or recently discharged with the primary diagnosis of heart failure * Heart failure signs and symptoms at the time of hospital admission * Elevated N-terminal pro B-type natriuretic peptide (NTproBNP) ≥500 pg/mL or B-type natriuretic peptide (BNP) ≥125 pg/mL according to the local lab for patients in sinus rhythm; or elevated NTproBNP ≥1500 pg/mL or BNP ≥375 pg/mL for patients with atrial fibrillation (AF), measured during the current hospitalization or in the 72 hours prior to hospital admission * Fulfillment of protocol defined stabilization criteria (if randomized during hospitalization) * Treatment during the index hospitalization with at least 1 intravenous dose of a loop diuretic (e.g., furosemide, torsemide, bumetanide). * Negative pregnancy test and agreement to use adequate contraception during trial (female participants only) Exclusion Criteria: * Diagnosis of type 1 diabetes or prior history of diabetic ketoacidosis * Documented prior history of severe hyperkalemia in the setting of MRA use * Treatment with non-steroidal mineralocorticoid receptor antagonist (MRA) or SGLT2i * Estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² and/or potassium \>5.0 mmol/L * Acute myocardial infarction, coronary revascularization, valve replacement/repair, or implantation of a cardiac resynchronization therapy device within 30 days * Prior or planned heart transplant * Hemodynamically significant uncorrected primary cardiac valvular disease as primary cause of heart failure * Cardiomyopathy due to acute inflammatory heart disease, infiltrative diseases, accumulation diseases, muscular dystrophies, cardiomyopathy with reversible causes, known hypertrophic obstructive cardiomyopathy, complex congenital heart disease, or pericardial constriction * Probable alternative cause of participant's heart failure symptoms * Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors or moderate CYP3A4 inducers, or potent CYP3A4 inducers * Known hypersensitivity to the IP (active substance or excipients) * Any other condition or therapy which would make the patient unsuitable for this study
Get updates
Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
140 sites in 8 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
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Study contacts
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Contact
Email: •••••@•••••
Locations
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A Coruña, Galicia Investigative Site CON-38004
RECRUITINGA Coruña, Galicia, 15006, Spain
Contact Email: •••••@•••••
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Barcelona Investigative Site CON-38010
RECRUITINGBarcelona, 08907, Spain
Contact Email: •••••@•••••
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Belo Horizonte, Minas Gerais Investigative Site CON-21079
RECRUITINGBelo Horizonte, Minas Gerais, 30220-330, Brazil
Contact Email: •••••@•••••
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Bradenton, FL Investigative Site CON-10125
RECRUITINGBradenton, Florida, 34209, United States
Contact Email: •••••@•••••
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CON-10001, Aurora, CO
RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
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CON-10002 Kansas City, MO Investigative Site
RECRUITINGKansas City, Missouri, 64111, United States
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CON-10004 Fairhope, AL Investigational Site
RECRUITINGFairhope, Alabama, 36532, United States
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CON-10005, Denver, CO
RECRUITINGDenver, Colorado, 80204, United States
Contact Email: •••••@•••••
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CON-10009, Norfolk, VA
RECRUITINGNorfolk, Virginia, 23507, United States
Contact Email: •••••@•••••
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CON-10015 Austin, TX Investigational Site
RECRUITINGAustin, Texas, 78705, United States
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CON-10018, Omaha, NE
RECRUITINGOmaha, Nebraska, 68105, United States
Contact Email: •••••@•••••
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CON-10019, Peoria, IL
RECRUITINGPeoria, Illinois, 61603, United States
Contact Email: •••••@•••••
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CON-10021, Glenview, IL
RECRUITINGGlenview, Illinois, 60026, United States
Contact Email: •••••@•••••
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CON-10022 Atlanta, GA Investigational Site
RECRUITINGAtlanta, Georgia, 30303, United States
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CON-10023, San Francisco, CA
RECRUITINGSan Francisco, California, 94118, United States
Contact Email: •••••@•••••
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CON-10024 Sacramento, CA Investigational Site
RECRUITINGSacramento, California, 95816, United States
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CON-10025, Naperville, IL
RECRUITINGNaperville, Illinois, 60540, United States
Contact Email: •••••@•••••
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CON-10030 Baton Rouge, LA Investigational Site
RECRUITINGBaton Rouge, Louisiana, 70808, United States
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CON-10041, Island Lake, IL
RECRUITINGIsland Lake, Illinois, 60042, United States
Contact Email: •••••@•••••
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CON-10045 Amarillo, TX Investigational Site
RECRUITINGAmarillo, Texas, 79106, United States
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CON-10051, Chattanooga, TN
RECRUITINGChattanooga, Tennessee, 37403, United States
Contact Email: •••••@•••••
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CON-10064, Merrillville, IN
RECRUITINGMerrillville, Indiana, 46410, United States
Contact Email: •••••@•••••
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CON-10075 El Centro, CA Investigational Site
RECRUITINGEl Centro, California, 92243, United States
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CON-10078, Hialeah, FL
RECRUITINGHialeah, Florida, 33012, United States
Contact Email: •••••@•••••
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CON-10079, Paducah, KY
RECRUITINGPaducah, Kentucky, 42003, United States
Contact Email: •••••@•••••
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CON-10080, Lexington, KY
RECRUITINGLexington, Kentucky, 40503, United States
Contact Email: •••••@•••••
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CON-10085, Houston, TX
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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CON-10086, Louisville, Kentucky
RECRUITINGLouisville, Kentucky, 40205, United States
Contact Email: •••••@•••••
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CON-10090, West Monroe, LA
RECRUITINGWest Monroe, Louisiana, 71291, United States
Contact Email: •••••@•••••
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CON-10105, Miami, FL
RECRUITINGMiami, Florida, 33135, United States
Contact Email: •••••@•••••
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CON-10109, Van Nuys, CA
RECRUITINGVan Nuys, California, 91405, United States
Contact Email: •••••@•••••
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CON-10113, Miramar, FL
RECRUITINGMiramar, Florida, 33027, United States
Contact Email: •••••@•••••
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CON-10119, Centerville, OH
RECRUITINGCenterville, Ohio, 45459, United States
Contact Email: •••••@•••••
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CON-10301, Fort Worth, TX
RECRUITINGFort Worth, Texas, 76104, United States
Contact Email: •••••@•••••
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CON-10304, Denison, TX
RECRUITINGDenison, Texas, 75020, United States
Contact Email: •••••@•••••
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CON-10305, Layton, UT
RECRUITINGLayton, Utah, 84041, United States
Contact Email: •••••@•••••
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CON-10318, Charlotte, NC
RECRUITINGCharlotte, North Carolina, 28207, United States
Contact Email: •••••@•••••
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CON-11001, Toronto, ON
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Email: •••••@•••••
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CON-11005 Sherbrooke, QC Investigational Site
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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CON-11007 North York, ON Investigational Site
RECRUITINGNorth York, Ontario, M6B 3H7, Canada
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CON-11008, Toronto, ON
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact Email: •••••@•••••
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CON-11010, London, ON
RECRUITINGLondon, Ontario, N6A 5A5, Canada
Contact Email: •••••@•••••
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CON-11011, Edmonton, AB
RECRUITINGEdmonton, Alberta, T6G 2B7, Canada
Contact Email: •••••@•••••
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CON-11012 Surry, BC Investigational Site
RECRUITINGSurrey, British Columbia, V3V OC6, Canada
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CON-11016, Sudbury, ON
RECRUITINGGreater Sudbury, Ontario, P3E 5J1, Canada
Contact Email: •••••@•••••
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CON-11019, Toronto, ON
RECRUITINGToronto, Ontario, M5B 1W8, Canada
Contact Email: •••••@•••••
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CON-11026, Montreal, Quebec
RECRUITINGMontreal, Quebec, H2X 1R9, Canada
Contact Email: •••••@•••••
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CON-21001, Recife, Recife
RECRUITINGRecife, Recife, 50720-110, Brazil
Contact Email: •••••@•••••
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CON-21003 Goiania, Goias Investigational Site
RECRUITINGGoiânia, Goiás, 74453-200, Brazil
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CON-21004 Braganca Paulista, Sao Paulo Investigational Site
RECRUITINGBragança Paulista, São Paulo, 12916542, Brazil
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CON-21005, Itaquera, São Paulo
RECRUITINGItaquera, São Paulo, 08270-120, Brazil
Contact Email: •••••@•••••
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CON-21007 Joinville, Santa Catarina Investigational Site
RECRUITINGJoinville, Santa Catarina, 89200-000, Brazil
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CON-21008, Caxias do Sul, Rio Grande do Sul
RECRUITINGCaxias do Sul, Rio Grande do Sul, 95070560, Brazil
Contact Email: •••••@•••••
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CON-21009, Poços de Caldas, Minas Gerais
RECRUITINGPoços de Caldas, Minas Gerais, 37706, Brazil
Contact Email: •••••@•••••
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CON-21010, Osasco, São Paulo
RECRUITINGOsasco, São Paulo, 06013-070, Brazil
Contact Email: •••••@•••••
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CON-21011, Presidente Prudente, São Paulo
RECRUITINGPresidente Prudente, São Paulo, 19050-680, Brazil
Contact Email: •••••@•••••
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CON-21013, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30441-070, Brazil
Contact Email: •••••@•••••
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CON-21014, Rio de Janeiro, Rio de Janeiro
RECRUITINGRio de Janeiro, Rio de Janeiro, 22240-006, Brazil
Contact Email: •••••@•••••
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CON-21016, Rio De Janeiro, Rio De Janeiro
RECRUITINGRio de Janeiro, Rio de Janeiro, 20551-030, Brazil
Contact Email: •••••@•••••
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CON-21017, Linhares, Espirito Santo
RECRUITINGLinhares, Espírito Santo, 29900-010, Brazil
Contact Email: •••••@•••••
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CON-21020, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30180-080, Brazil
Contact Email: •••••@•••••
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CON-21024, Natal, Rio Grande do Norte
RECRUITINGNatal, Rio Grande do Norte, 59020-500, Brazil
Contact Email: •••••@•••••
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CON-21028, Brasilia, Distrito Federal
RECRUITINGBrasília, Federal District, 70390-700, Brazil
Contact Email: •••••@•••••
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CON-21031, Votuporanga, São Paulo
RECRUITINGVotuporanga, São Paulo, 15505-189, Brazil
Contact Email: •••••@•••••
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CON-21032, Salvador, Bahia
RECRUITINGSalvador, Estado de Bahia, 40050-410, Brazil
Contact Email: •••••@•••••
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CON-21036, Rio Branco, Acre
RECRUITINGRio Branco, Acre, 69915-030, Brazil
Contact Email: •••••@•••••
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CON-21037, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 01323-001, Brazil
Contact Email: •••••@•••••
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CON-21038, Curitiba, Paraná
RECRUITINGCuritiba, Paraná, 80230-130, Brazil
Contact Email: •••••@•••••
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CON-21042, Passo Fundo, Rio Grande do Sul
RECRUITINGPasso Fundo, Rio Grande do Sul, 99010, Brazil
Contact Email: •••••@•••••
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CON-21047, Londrina, Paraná
RECRUITINGLondrina, Paraná, 86038, Brazil
Contact Email: •••••@•••••
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CON-21048, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 04004-30, Brazil
Contact Email: •••••@•••••
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CON-21049 Sao Paulo, Sao Paulo Investigational Site
RECRUITINGSão Paulo, São Paulo, 05652-900, Brazil
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CON-21051, Belo Horizonte, Minas Gerais
RECRUITINGBelo Horizonte, Minas Gerais, 30220-140, Brazil
Contact Email: •••••@•••••
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CON-21053, Aparecida de Goiânia, Goias
RECRUITINGAparecida de Goiânia, Goiás, 74936-600, Brazil
Contact Email: •••••@•••••
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CON-21056, Curitiba, Paraná
RECRUITINGCuritiba, Paraná, 80060-900, Brazil
Contact Email: •••••@•••••
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CON-21057, Atibaia, São Paulo
RECRUITINGAtibaia, São Paulo, 12944-060, Brazil
Contact Email: •••••@•••••
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CON-21058, Aracaju, Sergipe
RECRUITINGAracaju, Sergipe, 49055-210, Brazil
Contact Email: •••••@•••••
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CON-21062, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 01317-002, Brazil
Contact Email: •••••@•••••
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CON-21064, Arapiraca, Alagoas, Brazil
RECRUITINGArapiraca, Alagoas, 57315-745, Brazil
Contact Email: •••••@•••••
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CON-21074, São Paulo, São Paulo
RECRUITINGSão Paulo, São Paulo, 01229-010, Brazil
Contact Email: •••••@•••••
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CON-38001, Valencia, Valencia
RECRUITINGValencia, Valencia, 46010, Spain
Contact Email: •••••@•••••
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CON-38002, Madrid, Madrid
RECRUITINGMadrid, Madrid, 28034, Spain
Contact Email: •••••@•••••
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CON-38008, Santiago de Compostela, Galicia
RECRUITINGSantiago de Compostela, Galicia, 15706, Spain
Contact Email: •••••@•••••
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CON-38009, Manises, Valencia
RECRUITINGManises, Valencia, 46940, Spain
Contact Email: •••••@•••••
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CON-38011, Madrid, Madrid
RECRUITINGMadrid, Madrid, 28046, Spain
Contact Email: •••••@•••••
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CON-38012, Malaga, Malaga
RECRUITINGMálaga, Malaga, 29010, Spain
Contact Email: •••••@•••••
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CON-39001, Glasgow, UK
RECRUITINGGlasgow, G4 0SF, United Kingdom
Contact Email: •••••@•••••
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CON-39002, London, UK
RECRUITINGLondon, UK, SW17 0QT, United Kingdom
Contact Email: •••••@•••••
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CON-39007, Bristol, UK
RECRUITINGBristol, BS10 5NB, United Kingdom
Contact Email: •••••@•••••
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CON-39010, Bournemouth, Dorset
RECRUITINGBournemouth, Dorset, BH7 7DW, United Kingdom
Contact Email: •••••@•••••
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CON-51006, Ahmedabad, Gujarat
RECRUITINGAhmedabad, Gujarat, 380005, India
Contact Email: •••••@•••••
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CON-51009, Nagpur, Maharashtra
RECRUITINGNagpur, Maharashtra, 440033, India
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CON-51013, Bangalore, Karnataka
RECRUITINGBangalore, Karnataka, 560002, India
Contact Email: •••••@•••••
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CON-54001, Kandy, Central Province
RECRUITINGKandy, Central Province, 2000, Sri Lanka
Contact Email: •••••@•••••
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CON-54005, Colombo, Western Province
RECRUITINGColombo, Western Province, 01000, Sri Lanka
Contact Email: •••••@•••••
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CON-54007, Colombo, Western Province
RECRUITINGColombo, Western Province, 10350, Sri Lanka
Contact Email: •••••@•••••
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CON-54008, Ragama, Western Province
RECRUITINGRagama, Western Province, 11010, Sri Lanka
Contact Email: •••••@•••••
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CON-56001, Shanghai, Shanghai
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Email: •••••@•••••
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CON-56002, Guangzhou, Guangdong province
RECRUITINGGuangzhou, Guangdong, 510080, China
Contact Email: •••••@•••••
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CON-56003, Tianjin, Tianjin
RECRUITINGTianjin, Tianjin Municipality, 300052, China
Contact Email: •••••@•••••
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CON-56004, Jinan, Shandong Province
RECRUITINGJinan, Shandong, 250001/250021, China
Contact Email: •••••@•••••
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CON-56005, Taiyuan, Shanxi province
RECRUITINGTaiyuan, Shanxi, 030027, China
Contact Email: •••••@•••••
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CON-56006, Xi'an city, Shanxi Province
RECRUITINGXian City, Shanxi, 710038, China
Contact Email: •••••@•••••
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CON-56007, Chengdu City, Sichuan Province
RECRUITINGChengdu, Sichuan, 610072, China
Contact Email: •••••@•••••
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CON-56008, Changsha, Hunan
RECRUITINGChangsha, Hunan, 410011, China
Contact Email: •••••@•••••
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CON-56009, Shanghai, Shanghai
RECRUITINGShanghai, Shanghai Municipality, 200120, China
Contact Email: •••••@•••••
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CON-56010, Hangzhou, Zhejiang Province
RECRUITINGHangzhou, Zhejiang, 311200, China
Contact Email: •••••@•••••
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CON021043, Santo André, São Paulo
RECRUITINGSanto André, São Paulo, 09090-790, Brazil
Contact Email: •••••@•••••
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Campinas, São Paulo Investigative Site CON-21083
RECRUITINGCampinas, São Paulo, 13083-190, Brazil
Contact Email: •••••@•••••
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Chula Vista, CA Investigative Site CON-10111
RECRUITINGChula Vista, California, 91911, United States
Contact Email: •••••@•••••
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Colombo, Western Province, Investigative Site CON-54006
RECRUITINGColombo, Western Province, 01000, Sri Lanka
Contact Email: •••••@•••••
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Curitiba, Parana Investigative Site CON-21029
RECRUITINGCuritiba, Paraná, 80010-030, Brazil
Contact Email: •••••@•••••
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Fort Lauderdale, FL Investigative Site CON-10114
RECRUITINGFort Lauderdale, Florida, 33308, United States
Contact Email: •••••@•••••
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Fortaleza, Ceará Investigative Site CON-21055
RECRUITINGFortaleza, Ceará, 60864-190, Brazil
Contact Email: •••••@•••••
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Fortaleza, Ceará Investigative Site CON-21076
RECRUITINGFortaleza, Ceará, 60430275, Brazil
Contact Email: •••••@•••••
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Greenville, NC Investigative Site CON-10122
RECRUITINGGreenville, North Carolina, 27834, United States
Contact Email: •••••@•••••
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Houston, TX Investigative Site CON-10320
RECRUITINGHouston, Texas, 77058, United States
Contact Email: •••••@•••••
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Lexington, KY Investigative Site CON-10118
RECRUITINGLexington, Kentucky, 40536, United States
Contact Email: •••••@•••••
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Minneapolis, MN Investigative Site CON-10035
RECRUITINGMinneapolis, Minnesota, 55417, United States
Contact Email: •••••@•••••
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Morrisville, NC Investigative Site CON-10317
RECRUITINGMorrisville, North Carolina, 27560, United States
Contact Email: •••••@•••••
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New Delhi, Delhi Investigative Site CON-51004
RECRUITINGNew Delhi, 110017, India
Contact Email: •••••@•••••
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New Delhi, Delhi Investigative Site CON-51011
RECRUITINGNew Delhi, National Capital Territory of Delhi, 110029, India
Contact Email: •••••@•••••
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Philadelphia, PA Investigative Site CON-10068
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Email: •••••@•••••
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Phoenix, AZ Investigative Site CON-10115
RECRUITINGPhoenix, Arizona, 85006, United States
Contact Email: •••••@•••••
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Porto Alegre, RS Investigative Site CON-21019
RECRUITINGPorto Alegre, 90840-440, Brazil
Contact Email: •••••@•••••
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Porto Alegre, RS Investigative Site CON-21025
RECRUITINGPorto Alegre, Rio Grande do Sul, 90630-165, Brazil
Contact Email: •••••@•••••
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Porto Velho, Rondonia Investigative Site CON-21087
RECRUITINGPorto Velho, Rondônia, 76801-098, Brazil
Contact Email: •••••@•••••
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Recife, Pernambuco Investigative Site CON-21021
RECRUITINGRecife, Pernambuco, 50100-040, Brazil
Contact Email: •••••@•••••
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Recife, Pernambuco Investigative Site CON-21061
RECRUITINGRecife, Pernambuco, 52010-075, Brazil
Contact Email: •••••@•••••
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Recife, Pernambuco Investigative Site CON-21086
RECRUITINGRecife, Pernambuco, 51.110-160, Brazil
Contact Email: •••••@•••••
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Salem, VA Investigative Site CON-10048
RECRUITINGSalem, Virginia, 24153, United States
Contact Email: •••••@•••••
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San Francisco, CA Investigative Site CON-10315
RECRUITINGSan Francisco, California, 94110, United States
Contact Email: •••••@•••••
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Shanghai, China Investigative Site CON-56011
RECRUITINGShanghai, 200072, China
Contact Email: •••••@•••••
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São Carlos, São Paulo Investigative Site CON-21075
RECRUITINGSão Carlos, São Paulo, 13566-448, Brazil
Contact Email: •••••@•••••
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São José dos Campos, São Paulo Investigative Site CON-21081
RECRUITINGSão José dos Campos, São Paulo, 12243000, Brazil
Contact Email: •••••@•••••
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São Paulo Investigative Site CON-21066
RECRUITINGSão Paulo, 05403-000, Brazil
Contact Email: •••••@•••••
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Teresina, Piaui Investigative Site CON-21050
RECRUITINGTeresina, Piauí, 64001-450, Brazil
Contact Email: •••••@•••••
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Texarkana, TX Investigative Site CON-10319
RECRUITINGTexarkana, Texas, 75503, United States
Contact Email: •••••@•••••
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Valencia Investigative Site CON-38007
RECRUITINGValencia, 46026, Spain
Contact Email: •••••@•••••
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Vila Velha, Espírito Santo Investigative Site CON-21059
RECRUITINGVila Velha, Espírito Santo, 29118-060, Brazil
Contact Email: •••••@•••••
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