Should heart failure patients stay on jardiance in the hospital? new trial aims to find out

NCT ID NCT07038356

Recruiting now Disease control Sponsor: Christian Schulze Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial studies whether patients with acute decompensated heart failure who are already taking an SGLT2 inhibitor like empagliflozin should continue it during hospitalization. About 536 participants will either keep taking empagliflozin or switch to a placebo while in the hospital, then all take empagliflozin after discharge. The goal is to see if continuing the drug reduces death, heart failure events, and kidney decline over 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: empagliflozin (Jardiance)
What this could lead to: If successful, this could show that continuing empagliflozin during a heart failure hospital stay is safe and helps prevent death or further heart problems.
What could go wrong: This is a mid-stage trial with 536 participants, so results may not apply to everyone. There is a risk that continuing the drug offers no benefit or causes side effects like kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE DECOMPENSATED HEART FAILURE (ADHF)

Contacts and locations

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Locations

Herzzentrum Dresden GmbH Universitaetsklinik
NOT_YET_RECRUITING

Dresden, 01307, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Herzzentrum Leipzig GmbH
NOT_YET_RECRUITING

Leipzig, 04289, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Jena University Hospital
RECRUITING

Jena, Thuringia, 07747, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kerckhoff-Klinik GmbH
RECRUITING

Bad Nauheim, 61231, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
LMU Klinikum Muenchen AöR
NOT_YET_RECRUITING

München, 81377, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Rostock University Medical Center
NOT_YET_RECRUITING

Rostock, 18057, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitaetsklinikum Leipzig AöR
RECRUITING

Leipzig, 04103, Germany

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Universitaetsmedizin Goettingen
NOT_YET_RECRUITING

Göttingen, 37075, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
NOT_YET_RECRUITING

Mainz, 55131, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••

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