Can a simple supplement combo help heart failure patients exercise longer?
NCT ID NCT04913805
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether potassium nitrate, alone or combined with two supplements (propionyl-L-carnitine and nicotinamide riboside), can improve exercise endurance in people with a type of heart failure called HFpEF. About 53 participants will take these agents and undergo exercise tests to measure how long they can walk or cycle. The goal is to see if increasing blood flow and boosting muscle energy can help patients feel better and do more.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Potassium Nitrate, Propionyl-L-Carnitine, Nicotinamide Riboside
What this could lead to
If successful, this could point toward a combination therapy to improve exercise capacity and quality of life in people with HFpEF.
What could go wrong
This is a small, early-phase study with only 53 participants, so results may not apply broadly. The supplements may not show significant benefit or could cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••