Can a simple supplement combo help heart failure patients exercise longer?
NCT ID NCT04913805
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether potassium nitrate, alone or combined with two supplements (propionyl-L-carnitine and nicotinamide riboside), can improve exercise endurance in people with a type of heart failure called HFpEF. About 53 participants will take these agents and undergo exercise tests to measure how long they can walk or cycle. The goal is to see if increasing blood flow and boosting muscle energy can help patients feel better and do more.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Potassium Nitrate, Propionyl-L-Carnitine, Nicotinamide Riboside
- What this could lead to
- If successful, this could point toward a combination therapy to improve exercise capacity and quality of life in people with HFpEF.
- What could go wrong
- This is a small, early-phase study with only 53 participants, so results may not apply broadly. The supplements may not show significant benefit or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Other studies related to the condition(s) this trial covers.
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