Urine test could guide heart failure treatment and save lives

NCT ID NCT06092437

Recruiting now Disease control Sponsor: Zuyderland Medisch Centrum Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using urine sodium levels to adjust diuretic doses helps people with acute heart failure recover faster and live longer. About 556 adults hospitalized with acute heart failure will receive either standard care or a tailored diuretic plan. The goal is to see if this approach reduces deaths, heart failure events, and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: loop diuretics (furosemide) and other diuretics (thiazide, MRA, acetazolamide)
What this could lead to: If it works, this could lead to a more effective way to treat fluid buildup in acute heart failure, potentially reducing deaths and hospital visits.
What could go wrong: This is a mid-sized trial testing a treatment algorithm, not a new drug. The approach may not improve outcomes or could cause kidney issues. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE, ACUTE

Contacts and locations

Locations

Amphia ziekenhuis
RECRUITING

Breda, North Brabant, 4818 CK, Netherlands
Zuyderland MC
RECRUITING

Heerlen, Limburg, 6419 PC, Netherlands

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