ICD or not? landmark trial tests defibrillator necessity in seniors with heart failure.
NCT ID NCT05373940
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or medication alone, and track survival over four years. The goal is to see if skipping the ICD is safe and avoids unnecessary procedures in this age group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Implantable cardioverter defibrillator (ICD)
- What this could lead to
- If successful, this could show that older heart failure patients can safely skip an ICD and rely on medication alone, avoiding surgery and device risks.
- What could go wrong
- The trial is still recruiting and results are years away. It may find that skipping the ICD leads to more sudden cardiac deaths, or that the benefit of the ICD is too small to outweigh its risks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Amiens-Picardie-Site sud
RECRUITINGAmiens, 80054, France
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CHU Brest - Hôpital La Cavale Blanche
RECRUITINGBrest, 29200, France
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CHU Grenoble Alpes
RECRUITINGLa Tronche, 38700, France
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CHU Poitiers
RECRUITINGPoitiers, 86021, France
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CHU Strasbourg
RECRUITINGStrasbourg, 67200, France
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CHU de Nantes
RECRUITINGNantes, 44093, France
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CHU de Rouen
RECRUITINGRouen, 76000, France
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Centre Cardiologique du Nord
RECRUITINGSaint-Denis, 93207, France
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Centre Hospitalier d'Aix en provence
RECRUITINGAix-en-Provence, 13616, France
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Clinique Pasteur
RECRUITINGToulouse, 31076, France
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Groupement d'Hôpitaux de l'Institut Catholique de Lille
RECRUITINGLomme, 59462, France
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Hôpital Bichat - Claude Bernard
RECRUITINGParis, 75014, France
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Hôpital Pitié-Salpétrière
RECRUITINGParis, 75013, France
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Hôpital Pontchaillou
RECRUITINGRennes, 35033, France
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Hôpital Trousseau
RECRUITINGTours, 37170, France
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Hôpital de Brabois
RECRUITINGNancy, 54710, France
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Hôpital de La Timone
RECRUITINGMarseille, 13385, France
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Hôpital européen Georges Pompidou
RECRUITINGParis, , 75015, France
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HôpitalHenri Mondor
RECRUITINGCréteil, 94000, France
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