HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
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Heart failure drug trial pulled before it even started
Disease control TerminatedThis study was designed to test a drug called CDR132L in about 130 people with a type of heart failure where the heart pumps normally but is stiff. The goal was to see if the drug could reverse harmful changes in the heart muscle. However, the trial was withdrawn before any parti…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardior Pharmaceuticals GmbH • Aim: Disease control
Last updated May 17, 2026 03:08 UTC
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New combo drug may ease strain on failing hearts with leaky valves
Disease control OngoingThis study looks at whether adding sacubitril-valsartan to standard care helps people with heart failure (where the heart pumps normally but is stiff) and a moderate or worse leaky mitral valve. About 84 adults will take either the study drug plus usual treatment or usual treatme…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Ziekenhuis Oost-Limburg • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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Could a diabetes drug ease two heart conditions at once?
Disease control OngoingThis study tests a drug called enavogliflozin in 541 adults with heart failure and a leaky heart valve (tricuspid regurgitation). Participants take the drug or a placebo for 18 months. The goal is to see if the drug lowers the risk of heart-related death, hospital stays, or worse…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Asan Medical Center • Aim: Disease control
Last updated May 13, 2026 15:58 UTC
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New shot aims to ease heart failure and shed pounds in obese patients
Disease control OngoingThis study tests an experimental injection called HRS9531 in 200 obese adults with a type of heart failure where the heart pumps normally but is stiff. Participants receive either the drug or a placebo for 52 weeks. The goal is to see if the drug improves heart failure symptoms a…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Fujian Shengdi Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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Wearable tech sheds light on heart failure mystery
Knowledge-focused OngoingThis study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF and those without it. Researchers will compare daily activity levels and other measurements betw…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated May 17, 2026 03:09 UTC
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New study tests heart failure drugs in patients with kidney problems
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body fluids and certain che…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Horng Chen • Aim: Knowledge-focused
Last updated May 17, 2026 03:09 UTC
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Researchers track heart failure patients to uncover key factors affecting outcomes
Knowledge-focused OngoingThis study creates a hospital registry of 240 patients hospitalized for acute decompensated heart failure with preserved ejection fraction (HFpEF). Researchers will collect data on gender, medical history, body composition, and biomarkers to identify factors linked to short- and …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: National Medical Research Center for Therapy and Preventive Medicine • Aim: Knowledge-focused
Last updated May 17, 2026 03:08 UTC
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Your own personal drug trial: a new way to tweak heart meds
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests a personalized approach called N-of-1 trials to help older adults with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. About 20 participants will try different medication schedules and report their confidence and preferenc…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Weill Medical College of Cornell University • Aim: Knowledge-focused
Last updated May 15, 2026 11:53 UTC
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Study tests if exercise can ease fatigue in heart failure patients
Knowledge-focused OngoingThis study looks at how exercise training might help Veterans with heart failure with preserved ejection fraction (HFpEF) feel less tired and exercise longer. Researchers want to understand the role of nerves in the leg muscles that may limit exercise ability. 45 Veterans with HF…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 11, 2026 20:39 UTC