HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
Never miss a new study
Get alerted when new HEART FAILURE WITH PRESERVED EJECTION FRACTION trials appear
Sign up with your email to follow new studies for HEART FAILURE WITH PRESERVED EJECTION FRACTION, keep track of the ones that matter, and come back to a personal dashboard instead of checking manually.
By submitting, you agree to our Terms of use
-
Which diabetes pill is better for your heart? huge study aims to find out
Disease control OngoingThis large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jul 02, 2026 02:00 UTC
-
Heart shunt shows promise for easing heart failure symptoms
Disease control OngoingThis study tests a device called the Edwards APTURE shunt, which is implanted in the heart to create a small opening that lowers pressure. The goal is to see if it can improve symptoms and quality of life for 100 people with a certain type of heart failure. Half of the participan…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
-
New heart failure drug JK07 enters Mid-Stage trial
Disease control OngoingThis Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Salubris Biotherapeutics Inc • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
-
Ultrasound zaps lung nerves to ease heart failure symptoms
Disease control ENROLLING_BY_INVITATIONThis early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Gradient Denervation Technologies • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
-
Which diabetes drug protects the heart better? large study aims to find out
Disease control OngoingThis large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
-
Heart failure patients get a tiny shunt without a permanent implant
Disease control ENROLLING_BY_INVITATIONThis study tests a device that creates a small opening between the heart's upper chambers to relieve pressure in people with chronic heart failure. Unlike other shunts, this one leaves no permanent implant behind. The trial will compare the device to a sham procedure in 700 patie…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Alleviant Medical, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
-
Heart failure drug trial pulled before it even started
Disease control TerminatedThis was a planned Phase 2 study testing a drug called CDR132L in about 130 people with heart failure and a preserved or mildly reduced ejection fraction. The drug aimed to reverse harmful changes in the heart muscle. However, the trial was withdrawn before any participants were …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardior Pharmaceuticals GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
-
Diabetes drug could help heart failure patients with leaky valve
Disease control OngoingThis study tests whether enavogliflozin, a diabetes drug, can improve outcomes in people with heart failure and a leaky tricuspid valve. About 541 participants will receive either the drug or a placebo for 18 months. Researchers will track heart-related events, valve worsening, a…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Asan Medical Center • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
-
New injection aims to help obese heart failure patients lose weight and feel better
Disease control OngoingThis Phase 2 study tests an injectable drug called HRS9531 in 203 obese adults with a type of heart failure where the heart pumps normally but is stiff. Participants receive either the drug or a placebo for 52 weeks. The main goals are to see if the drug helps with weight loss an…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Fujian Shengdi Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
-
New study aims to simplify diagnosis of hidden heart failure in breathless patients
Diagnosis OngoingThis study looks at better ways to diagnose a type of heart failure called HFpEF in people who have unexplained shortness of breath. Researchers will compare non-invasive tests to the standard invasive method in 30 adults aged 18-90. The goal is to make diagnosis easier and more …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University of Leipzig • Aim: Diagnosis
Last updated Jun 27, 2026 07:58 UTC
-
Arctic work and heart risk: new study probes hidden dangers
Knowledge-focused OngoingThis study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
-
Massive claims study aims to validate Real-World evidence for heart failure drugs
Knowledge-focused OngoingThis study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
-
Can we tell diabetic heart disease apart from other heart conditions?
Knowledge-focused OngoingThis study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
-
Can your smartwatch spot heart failure clues?
Knowledge-focused OngoingThis study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare 60 adults with and without HFpEF using tests like MRI, exercise testin…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
-
Exercise may unlock better stamina for heart failure patients
Knowledge-focused OngoingThis study looks at why Veterans with heart failure with preserved ejection fraction (HFpEF) get tired so easily during exercise. Researchers will block nerve signals from leg muscles to see how that affects blood flow and fatigue, both before and after a regular exercise program…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
-
Could a blood pressure cuff help heart failure? small study investigates
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests whether a noninvasive procedure called remote ischemic preconditioning can improve blood vessel function in people with suspected heart failure with preserved ejection fraction. Participants will have a blood pressure cuff inflated around their arm in cycles, whi…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Castilla-La Mancha • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
-
New MRI study aims to spot heart failure before it starts
Knowledge-focused ENROLLING_BY_INVITATIONThis study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
-
Heart failure mystery: new registry aims to unlock patient outcomes
Knowledge-focused OngoingThis study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: National Medical Research Center for Therapy and Preventive Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
-
Can a tailored trial help heart patients decide on Beta-Blockers?
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests whether a personalized 'N-of-1' trial can help older adults with a type of heart failure (HFpEF) decide if they want to continue or stop taking beta-blockers. Twenty participants will go through periods on and off their beta-blocker, in a random order, to see how…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Weill Medical College of Cornell University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
-
New drug combo tested for stubborn heart failure
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney f…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Horng Chen • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC