Ultrasound zaps lung nerves to ease heart failure symptoms

NCT ID NCT06052072

ENROLLING_BY_INVITATION Disease control Sponsor: Gradient Denervation Technologies Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will be followed for safety and changes in blood vessel resistance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gradient Denervation System (ultrasound ablation device)
What this could lead to: If it works, this could offer a new way to manage heart failure and pulmonary hypertension, potentially improving daily life and reducing symptoms.
What could go wrong: This is a very early, small feasibility study with only 50 participants. The procedure carries risks like serious adverse events, and it is not yet known if it will provide lasting benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GROUP 2 PULMONARY HYPERTENSION HEART FAILURE

Contacts and locations

Locations

Aurora Health

Milwaukee, Wisconsin, 53215, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Duke University

Durham, North Carolina, 27708, United States
Houston Methodist

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Northwestern University

Chicago, Illinois, 60611, United States
University of Wisconsin

Madison, Wisconsin, 53705, United States

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