Could a smart pacemaker ease a common type of heart failure?

NCT ID NCT05839730

Ongoing Disease control Sponsor: Medtronic Cardiac Rhythm and Heart Failure Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests a modified pacemaker designed to improve heart function and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive either the active pacing therapy or a non-pacing mode. Researchers will measure changes in heart structure, exercise capacity, and symptoms over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pacemaker with personalized lower rate and tachycardia remodeling therapy
What this could lead to: If it works, this could offer a new way to improve exercise ability and daily life for people with a common type of heart failure.
What could go wrong: This is an early feasibility study with only 105 people, so results may not apply to everyone. The therapy involves a device implant, which carries risks like infection or pacing discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONCENTRIC HYPERTROPHY HEART FAILURE WITH PRESERVED EJECTION FRACTION

Contacts and locations

Locations

Duke University

Durham, North Carolina, 27708, United States
Houston Methodist Research Institute

Houston, Texas, 77030, United States
NCH Heart Institute

Naples, Florida, 34102, United States
Oklahoma Heart Hospital

Oklahoma City, Oklahoma, 73120, United States
Prairie Education and Research Cooperative-St. Elizabeth's

O'Fallon, Illinois, 62269, United States
Prairie Education and Research Cooperative-St. John's

Springfield, Illinois, 62769, United States
The University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

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