HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
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New drug shows promise for Hard-to-Treat heart and lung condition
Disease control Recruiting nowThis study tests an experimental drug called TX000045 in people who have high blood pressure in the lungs caused by a specific type of heart failure (HFpEF). About 180 adults will receive either the drug or a placebo for 24 weeks to see if it improves blood flow and is safe. The …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Tectonic Therapeutic • Aim: Disease control
Last updated May 17, 2026 04:37 UTC
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New hope for stiff heart? drug trial targets Tough-to-Treat heart failure
Disease control Recruiting nowThis study tests a new drug called HRS-1893 in 48 people with a type of heart failure where the heart pumps well but is too stiff (heart failure with preserved ejection fraction). The main goal is to check if the drug is safe and tolerable. Researchers will also measure changes i…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Shandong Suncadia Medicine Co., Ltd. • Aim: Disease control
Last updated May 17, 2026 04:34 UTC
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Can a smartphone app replace hospital rehab for heart failure?
Disease control Recruiting nowThis study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for 100 adults with heart failure. Participants use digital tools to track activity and improve health behaviors. The goal is to see if this approach boosts physical activity, quali…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated May 17, 2026 04:18 UTC
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New heart implant could ease symptoms for millions with heart failure
Disease control Recruiting nowThis study tests a small implanted device that sends gentle electrical signals to the heart to help it pump better. It is for people with heart failure whose heart still pumps somewhat well (ejection fraction 40-70%). The goal is to see if the device improves walking ability and …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Impulse Dynamics • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New hope for stiff heart failure: device aims to boost blood flow
Disease control Recruiting nowThis study looks at a device called the Coronary Sinus Reducer in people with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD). The device is implanted to improve blood flow to the heart muscle. Researchers will use MRI scans to …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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New drug aims to cut heart failure hospitalizations in obese patients
Disease control Recruiting nowThis study tests a new drug, maridebart cafraglutide, in about 5,000 adults with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and improves symptoms. Participants receive the drug or a placebo alongside standard care.
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Amgen • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New clinic aims to keep heart failure patients out of the hospital
Disease control Recruiting nowThis study tests whether a special clinic can help heart failure patients avoid being readmitted to the hospital after they go home. About 150 adults with a type of heart failure called HFpEF will receive extra education, tools like a blood pressure monitor, and follow-up phone c…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Hackensack Meridian Health • Aim: Disease control
Last updated May 11, 2026 20:52 UTC
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Could a pacemaker plus ablation beat pills for heart failure patients with AFib?
Disease control Recruiting nowThis study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved pumping ability. One group gets a pacemaker plus a procedure to calm the heart's electrical signals, while the other continues with standard heart-rate-controlling me…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: French Cardiology Society • Aim: Disease control
Last updated Apr 26, 2026 19:36 UTC
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New exercise MRI could unmask hidden heart failure
Diagnosis Recruiting nowThis study tests a new, noninvasive exercise MRI technique to better diagnose and understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still fails. Researchers will enroll 400 people, including those with HFpEF, those w…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated May 15, 2026 11:53 UTC
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Heart failure patients may get a boost: new drug combo targets exercise endurance
Symptom relief Recruiting nowThis study tests whether two medications—empagliflozin and potassium nitrate—can help people with a type of heart failure (HFpEF) exercise longer. About 53 adults with stable heart failure will take these drugs to see if they improve muscle energy and blood flow. The goal is to f…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated May 17, 2026 04:35 UTC
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Pacemaker study aims to boost stamina in heart failure patients
Symptom relief Recruiting nowThis study looks at whether a pacemaker can improve exercise ability and quality of life in people with heart failure with preserved ejection fraction (HFpEF) who also have a small heart chamber and a low heart rate during activity. Thirty participants will receive a pacemaker an…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia • Aim: Symptom relief
Last updated May 17, 2026 04:29 UTC
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Iron shot boosts heart Patients' stamina in new trial
Symptom relief Recruiting nowThis study tests whether a single dose of intravenous iron can improve exercise capacity in adults with a specific type of heart failure (HFpEF) who also have low iron levels. Researchers will measure changes in peak oxygen uptake during exercise tests over 12 weeks. The trial in…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 15, 2026 11:56 UTC
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Can a simple supplement boost heart health in veterans?
Symptom relief Recruiting nowThis study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 veterans will take part. The goal is to see if these treatments help…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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Heat therapy for heart failure: a warm legs approach to better exercise
Symptom relief Recruiting nowThis study tests whether daily leg heat therapy can improve exercise ability in people with heart failure with preserved ejection fraction (HFpEF). Participants will use water-circulating trousers heated to 42°C for 90 minutes each day at home. The goal is to see if this treatmen…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated May 14, 2026 12:03 UTC
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Could a pacemaker ease heart failure symptoms? new study investigates
Symptom relief Recruiting nowThis study is testing whether special pacing therapies can improve exercise ability and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive pacing and be followed for up to 12 months. The goal is to see if thi…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Medtronic Cardiac Rhythm and Heart Failure • Aim: Symptom relief
Last updated May 13, 2026 16:03 UTC
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Diet over drugs? new study tests Low-Calorie plan to ease heart failure symptoms
Symptom relief Recruiting nowThis study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and help people walk farther. It includes 63 adults with heart failure with preserved ejection fraction, obesity, and type 2 diabetes. Participants are randomly as…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2, PHASE3 • Sponsor: University of Leicester • Aim: Symptom relief
Last updated May 01, 2026 15:59 UTC
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Menopause-Heart link: scientists probe tissue for clues
Knowledge-focused Recruiting nowThis study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 women undergoing heart surgery to understand how the loss of estrogen affects heart energy and blood vessel health. The goal is to uncover bi…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated May 17, 2026 04:29 UTC
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New scan could reveal hidden heart damage in common heart failure
Knowledge-focused Recruiting nowThis study is testing a special PET scan that uses a tracer called FAPI to look for scarring in the heart. It involves 35 adults with a type of heart failure where the heart pumps normally but still doesn't work well. The goal is to see if this scan can help doctors better unders…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 17, 2026 04:15 UTC
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Blood test may spot hidden heart risk in diabetes patients
Knowledge-focused Recruiting nowThis study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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40,000 heart patients monitored in real time
Knowledge-focused Recruiting nowThis study is creating a live registry to track heart failure patients across the Yale New Haven Health System. Researchers will monitor hospitalizations and use of recommended treatments in up to 40,000 participants. The goal is to better understand and improve heart failure car…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Yale University • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Can fixing breathing boost exercise in heart failure patients?
Knowledge-focused Recruiting nowThis study looks at whether breathing limitations make it harder for people with heart failure and obesity to exercise. Researchers will measure how much oxygen breathing takes and if special gas mixtures help with shortness of breath and exercise ability. About 78 adults aged 55…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated May 13, 2026 15:58 UTC
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Diabetes drug's hidden heart benefit under microscope
Knowledge-focused Recruiting nowThis study looks at how a common diabetes medicine (SGLT2 inhibitor) affects the heart and muscles in people with type 2 diabetes and heart failure. Researchers want to see if the medicine's effect on ketones helps improve energy use in the heart and muscles. About 30 adults will…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: EARLY_PHASE1 • Sponsor: The University of Texas Health Science Center at San Antonio • Aim: Knowledge-focused
Last updated May 11, 2026 20:51 UTC
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Heart MRI breakthrough could unlock Diabetes-HFpEF mystery
Knowledge-focused Recruiting nowThis study uses a new type of heart MRI scan with a special dye (manganese) to take detailed pictures of the heart. Researchers want to learn why people with both heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes often have worse outcomes. They will compa…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University of Leicester • Aim: Knowledge-focused
Last updated May 11, 2026 20:49 UTC
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Heart failure study aims to personalize care for 1,000 patients
Knowledge-focused Recruiting nowThis study looks at heart failure, a condition where the heart can't pump enough blood, causing shortness of breath and tiredness. Researchers will collect data from 1,000 adults, including heart images and blood tests, to find different types of heart failure. The goal is to hel…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 11, 2026 20:39 UTC
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Kidney drug shows heart hints in early trial
Knowledge-focused Recruiting nowThis study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 07, 2026 18:38 UTC
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Heart failure patients pause Beta-Blockers in new study
Knowledge-focused Recruiting nowThis study looks at what happens when 30 people with a certain type of heart failure (HFpEF) stop taking their beta-blocker medication for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life. The goal is to learn whether stopping bet…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: UConn Health • Aim: Knowledge-focused
Last updated May 06, 2026 16:01 UTC
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Heart biopsies aim to unlock secrets of common heart failure
Knowledge-focused Recruiting nowThis study looks at heart tissue from 180 adults with a type of heart failure called HFpEF. Researchers will take tiny samples of heart muscle during a standard procedure to find changes that could lead to new treatments. The goal is to understand the disease better, not to test …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Apr 26, 2026 19:37 UTC