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Could a diabetes drug help heart failure patients after valve surgery?

NCT ID NCT05672836

Recruiting now Disease control Sponsor: Duk-Woo Park, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether a drug called enavogliflozin can prevent major heart problems or worsening heart failure in people who have had a heart valve replacement (TAVR) and still have heart failure. About 1,040 participants will receive either the drug or a placebo, in addition to standard care. The main goal is to see if the drug reduces the chance of death, heart attack, stroke, or hospitalization for heart failure over one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Enavogliflozin (a drug that helps the kidneys remove sugar from the blood, also used for diabetes)
What this could lead to
If it works, this could provide a new treatment option to reduce heart failure hospitalizations and major heart problems in patients who have had a valve replacement.
What could go wrong
This is a phase 4 trial, so the drug is already approved for diabetes, but its benefit in this specific heart condition is unproven. The trial may show no advantage over placebo, and side effects like dehydration or infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS HEART FAILURE

Contacts and locations

Locations

  • Asan Medical Center

    RECRUITING

    Seoul, South Korea

  • Bucheon Sejong Hospital

    RECRUITING

    Bucheon-si, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chungnam National University Hospital

    RECRUITING

    Daejeon, South Korea

  • Daegu Catholic University Medical Center

    RECRUITING

    Daegu, South Korea

  • Dong-A Medical Center

    RECRUITING

    Pusan, South Korea

  • Ewha Womans University Mokdong Hospital

    RECRUITING

    Seoul, South Korea

  • Ewha Womans University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Gachon University Gil Hospital

    RECRUITING

    Incheon, South Korea

  • Gangneung Asan Hospital

    RECRUITING

    Gangneung, South Korea

  • Gyeongsang National University Changwon Hospital

    RECRUITING

    Changwon, South Korea

  • Hanyang University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Incheon Sejong Hospital

    RECRUITING

    Incheon, South Korea

  • Inha University Hospital

    RECRUITING

    Incheon, South Korea

  • Inje University Ilsan Paik Hospital

    RECRUITING

    Ilsan, South Korea

  • Inje University Pusan Paik Hospital

    RECRUITING

    Pusan, South Korea

  • Keimyung University Dongsan Medical Center

    RECRUITING

    Daegu, South Korea

  • Konkuk University Medical Center

    RECRUITING

    Seoul, South Korea

  • Korea University Anam Hospital

    RECRUITING

    Seoul, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Kyungpook National University Hospital

    RECRUITING

    Daegu, South Korea

  • Pusan National University Hospital

    RECRUITING

    Pusan, South Korea

  • SNU Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul university Bundang hospital

    RECRUITING

    Seongnam-si, South Korea

  • The Catholic Univ. of Korea Eunpyeong St. Mary's hospital

    RECRUITING

    Seoul, South Korea

  • The Catholic University of Korea, Daejeon ST. Mary's Hospital

    RECRUITING

    Daejeon, South Korea

  • The Catholic University of Korea, Incheon St. Mary's Hospital

    RECRUITING

    Incheon, South Korea

  • The Catholic University of Korea, ST. Vincent's Hospital

    WITHDRAWN

    Suwon, South Korea

  • Uijeongbu Eulji Medical Center, Eulji University

    WITHDRAWN

    Uijeongbu-si, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

  • Yeungnam University Medical Center

    WITHDRAWN

    Daegu, South Korea

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