HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
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Heart failure drug shows promise for Non-Diabetic patients
Disease control CompletedThis study tested whether the drug sotagliflozin can improve heart function in people with a type of heart failure called HFpEF who do not have diabetes. Eighty-eight participants took either the drug or a placebo for six months. Researchers used heart scans and exercise tests to…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Juan Badimon • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Heart failure drug combo shows promise for leaky valve patients
Disease control CompletedThis study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Ziekenhuis Oost-Limburg • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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Can a beta-blocker help a common type of heart failure? new study investigates.
Disease control CompletedThis study tested whether a slow-release form of the beta-blocker carvedilol can improve heart function in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff. 63 adults with high blood pressure and signs…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Seoul National University Bundang Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Gut health breakthrough? probiotic shows promise for heart failure
Disease control CompletedThis study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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Exercise program shows promise for elderly heart failure patients
Disease control CompletedThis study tested a 12-week cardiac rehabilitation program in 65 elderly patients (70+) with heart failure. The program included strength and aerobic exercises twice a week. Researchers measured changes in movement, heart function, and fitness. The goal was to see if exercise can…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Malaga • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Could a common heart drug protect HIV patients from heart failure?
Disease control CompletedThis study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Which blood pressure pill works best for this type of heart failure?
Disease control CompletedThis study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Heart failure drug shows promise for Non-Diabetics
Disease control CompletedThis completed study tested whether empagliflozin, a diabetes drug, can improve heart structure and function in 50 non-diabetic patients with heart failure with preserved ejection fraction. Participants took either empagliflozin or a placebo daily. Researchers measured heart stre…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Damanhour University • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Weight-Loss drug semaglutide shows promise for heart failure with diabetes
Disease control CompletedThis study tested whether a weekly injection of semaglutide (2.4 mg) can improve heart failure symptoms and reduce body weight in 617 people with obesity-related heart failure with preserved ejection fraction and type 2 diabetes. Participants received either semaglutide or a plac…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Novo Nordisk A/S • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Heart MRI breakthrough: new scan could replace needle biopsy for rare heart disease
Diagnosis CompletedThis study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University of Leipzig • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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Simple stress echo upgrade may spot hidden stiff heart
Diagnosis CompletedThis study looked at whether taking extra ultrasound images during a standard stress echocardiogram can help doctors figure out if chest pain or shortness of breath is caused by a stiff heart (heart failure with preserved ejection fraction, or HFpEF). Researchers enrolled 30 peop…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Duke University • Aim: Diagnosis
Last updated Jun 27, 2026 08:05 UTC
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New blood test may spot hidden heart failure in seniors
Diagnosis CompletedThis study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Shocking recovery: muscle zaps may help heart patients get back on their feet
Symptom relief CompletedThis study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Vermont Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a common diabetes drug help older heart failure patients move better?
Symptom relief CompletedThis study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, qualit…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a diabetes drug ease heart failure in rare amyloid disease?
Symptom relief CompletedThis study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Sleep coaching shows promise for heart failure patients in tiny pilot
Symptom relief CompletedThis pilot study tested whether sleep coaching and sleep hygiene training could help people with a common type of heart failure (HFpEF) sleep better and feel better. Ten participants wore activity trackers and kept sleep diaries to see if they could gradually extend their sleep t…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Symptom relief
Last updated Jun 26, 2026 14:03 UTC
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Can special exercise programs help heart failure patients breathe easier?
Knowledge-focused CompletedThis study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Hidden heart condition found in many with stiff heart failure
Knowledge-focused CompletedThis study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University Tunis El Manar • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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French study tracks sleep quality in central apnea patients using smart ventilator
Knowledge-focused CompletedThis study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Société Française de Recherche et de Médecine du Sommeil • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can patient reports predict heart failure shifts?
Knowledge-focused CompletedThis completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Intermountain Health Care, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Heart fat linked to pump problems in common heart failure
Knowledge-focused CompletedThis study looked at over 1,000 adults with a type of heart failure called HFpEF, where the heart pumps normally but is too stiff. Researchers measured the fat around the heart using ultrasound and checked how well the heart was working. The goal was to see if more heart fat is l…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Dongying Zhang • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC