Could a common diabetes drug help older heart failure patients move better?
NCT ID NCT05093959
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, quality of life, and markers of inflammation and gut health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, this could point toward a simple, affordable treatment to improve exercise ability and daily life for older adults with this type of heart failure.
What could go wrong
This is a small, early-phase trial with only 86 participants, so results may not apply to everyone. Metformin can cause gastrointestinal side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atrium Health Sanger Heart and Vascular Clinic Institute
Charlotte, North Carolina, 28203, United States
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Wake Forest School of Medicine
Winston-Salem, North Carolina, 27157, United States