Which blood pressure pill works best for this type of heart failure?

NCT ID NCT04434664

Completed Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The goal was to see which drug better controlled blood pressure in this specific heart condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: amlodipine and metoprolol
What this could lead to: If successful, this could help doctors choose better blood pressure medications for people with a common type of heart failure.
What could go wrong: This is a small, completed study (50 participants) that may not apply to all patients. It compared two existing drugs, so no new treatment was discovered.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION HYPERTENSION

Contacts and locations

Locations

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

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