Can a beta-blocker help a common type of heart failure? new study investigates.

NCT ID NCT05553314

Completed Disease control Sponsor: Seoul National University Bundang Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a slow-release form of the beta-blocker carvedilol can improve heart function in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff. 63 adults with high blood pressure and signs of heart strain took either the drug or a placebo for 6 months. Researchers measured changes in a blood marker (NT-proBNP) and heart muscle strain (GLS) to see if the drug helps.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BETA BLOCKER HEART FAILURE WITH PRESERVED EJECTION FRACTION MYOCARDIAL STRAIN

Contacts and locations

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Locations

Samsung Medical Center

Seoul, Il-won, 06351, South Korea
Wonju Severance Christian Hospital

Wŏnju, WONJU, 26426, South Korea