Could a pacemaker plus ablation beat pills for heart failure patients with AFib?
NCT ID NCT06833138
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medications. The goal is to see if the pacemaker-ablation combo reduces deaths and heart failure hospitalizations over two years. About 266 participants will be followed with clinic visits at 3, 12, and 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pacemaker implantation and atrioventricular node ablation
- What this could lead to
- If this works, it could offer a better way to manage heart failure and atrial fibrillation, potentially reducing hospital stays and improving survival.
- What could go wrong
- This is a mid-sized trial (266 people) and the procedure carries risks like bleeding, infection, or heart damage. It may not prove better than current medications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHRU Lille
NOT_YET_RECRUITINGLille, 59000, France
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CHRU de Brest - Hôpital de la Cavale Blanche
NOT_YET_RECRUITINGBrest, 29200, France
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CHRU de Caen
NOT_YET_RECRUITINGCaen, 14000, France
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CHRU de Tours - Trousseau
NOT_YET_RECRUITINGChambray-lès-Tours, 37170, France
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CHU Grenoble Alpes
NOT_YET_RECRUITINGGrenoble, 38043, France
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CHU Poitiers
RECRUITINGPoitiers, 86021, France
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CHU de Bordeaux - Hôpital Cardiologique du Haut-Lévèque
NOT_YET_RECRUITINGPessac, 33604, France
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CHU de Nantes - Hôpital Nord Laennec
NOT_YET_RECRUITINGNantes, 44093, France
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CHU de Rouen
NOT_YET_RECRUITINGRouen, 76000, France
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Clinique Millenaire
NOT_YET_RECRUITINGMontpellier, 34000, France
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Clinique St Pierre Ottignies
NOT_YET_RECRUITINGOttignies-Louvain-la-Neuve, 1340, Belgium
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GHICL Allome - Hôpital St Philibert
NOT_YET_RECRUITINGLomme, 59462, France
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Groupe Hospitalier La Rochelle-Ré-Aunis
NOT_YET_RECRUITINGLa Rochelle, 17019, France
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OLV Aalst
NOT_YET_RECRUITINGAalst, 9300, Belgium
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UZ Leuven
NOT_YET_RECRUITINGLeuven, 3000, Belgium
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