Could a pacemaker plus ablation beat pills for heart failure patients with AFib?
NCT ID NCT06833138
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medications. The goal is to see if the pacemaker-ablation combo reduces deaths and heart failure hospitalizations over two years. About 266 participants will be followed with clinic visits at 3, 12, and 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pacemaker implantation and atrioventricular node ablation
What this could lead to
If this works, it could offer a better way to manage heart failure and atrial fibrillation, potentially reducing hospital stays and improving survival.
What could go wrong
This is a mid-sized trial (266 people) and the procedure carries risks like bleeding, infection, or heart damage. It may not prove better than current medications.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEART FAILURE WITH PRESERVED EJECTION FRACTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
CHRU Lille
NOT_YET_RECRUITINGLille, 59000, France
Contact
-
CHRU de Brest - Hôpital de la Cavale Blanche
NOT_YET_RECRUITINGBrest, 29200, France
Contact
-
CHRU de Caen
NOT_YET_RECRUITINGCaen, 14000, France
Contact
-
CHRU de Tours - Trousseau
NOT_YET_RECRUITINGChambray-lès-Tours, 37170, France
Contact
-
CHU Grenoble Alpes
NOT_YET_RECRUITINGGrenoble, 38043, France
Contact
-
CHU Poitiers
RECRUITINGPoitiers, 86021, France
Contact
-
CHU de Bordeaux - Hôpital Cardiologique du Haut-Lévèque
NOT_YET_RECRUITINGPessac, 33604, France
Contact
-
CHU de Nantes - Hôpital Nord Laennec
NOT_YET_RECRUITINGNantes, 44093, France
Contact
-
CHU de Rouen
NOT_YET_RECRUITINGRouen, 76000, France
Contact
-
Clinique Millenaire
NOT_YET_RECRUITINGMontpellier, 34000, France
Contact
-
Clinique St Pierre Ottignies
NOT_YET_RECRUITINGOttignies-Louvain-la-Neuve, 1340, Belgium
Contact
-
GHICL Allome - Hôpital St Philibert
NOT_YET_RECRUITINGLomme, 59462, France
Contact
-
Groupe Hospitalier La Rochelle-Ré-Aunis
NOT_YET_RECRUITINGLa Rochelle, 17019, France
Contact
-
OLV Aalst
NOT_YET_RECRUITINGAalst, 9300, Belgium
Contact
-
UZ Leuven
NOT_YET_RECRUITINGLeuven, 3000, Belgium
Contact