New hope for stiff heart? drug trial targets common heart failure

NCT ID NCT06122779

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests an experimental drug (BMS-986435/MYK-224) in people with a specific type of heart failure where the heart pumps normally but is too stiff (HFpEF). The main goal is to check the drug's safety and how the body processes it. About 208 adults with stable symptoms will receive either the drug or a placebo.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Abington Memorial Hospital
RECRUITING

Abington, Pennsylvania, 19001, United States

Contact Phone: •••-•••-••••
Angiocardiac Care of Texas - PA - PPDS
RECRUITING

Houston, Texas, 77025-5253, United States

Contact Phone: •••-•••-••••
Ascension Medical Group St. Vincent - Indianapolis Heart Care
RECRUITING

Indianapolis, Indiana, 46260-1992, United States

Contact
Ascension St. Vincent's Riverside Hospital - PPDS
RECRUITING

Jacksonville, Florida, 32204-4748, United States

Contact Phone: •••-•••-••••
Bluhm Cardiovascular Institute of Northwestern
RECRUITING

Chicago, Illinois, 60611-5969, United States

Contact
Bristol Royal Infirmary
RECRUITING

Bristol, BS2 8HW, United Kingdom

Contact Phone: •••-•••-••••
Capital Cardiology Associates
RECRUITING

Albany, New York, 12211, United States

Contact Phone: •••-•••-••••
Centro Cardiovascular Salta-Mariano Boedo 60
RECRUITING

Salta, A4406BPF, Argentina

Contact Phone: •••-•••-••••
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC-Galván 4102
RECRUITING

Buenos Aires, C1431FWO, Argentina

Contact Phone: •••-•••-••••
Centro de Especialidades Médicas CEMEDIC
RECRUITING

Buenos Aires, 1407, Argentina

Contact Phone: •••-•••-••••
Centro de Investigaciones Clínicas Del Litoral SRL
RECRUITING

Santa Fe, S3000FWO, Argentina

Contact Phone: •••-•••-••••
Chicago Medical Research, LLC - Hazel Crest
RECRUITING

Hazel Crest, Illinois, 60429-2196, United States

Contact Phone: •••-•••-••••
Chonnam National University Hospital
RECRUITING

Gwangju, Gwangju Gwang'yeogsi, 61469, South Korea

Contact Phone: •••-•••-••••
Chungnam National University Hospital
RECRUITING

Daejeon, Daejeon Gwang'yeogsi, 35015, South Korea

Contact Phone: •••-•••-••••
Clinical Trials UMED Sp. z o.o.
RECRUITING

Lódz, Lódzkie, 92-213, Poland

Contact Phone: •••-•••-••••
Clínica Privada Del Prado Sociedad de Responsabilidad Limitada
RECRUITING

Córdoba, Córdoba Province, 5000, Argentina

Contact Phone: •••-•••-••••
Colorado Heart and Vascular - Lakewood
RECRUITING

Lakewood, Colorado, 80228-1710, United States

Contact Phone: •••-•••-••••
Corporación Médica de General San Martín
RECRUITING

Ciudad del Libertador General San Martin, Buenos Aires, B1650BNB, Argentina

Contact Phone: •••-•••-••••
Duke Cardiology Clinic - PPDS
RECRUITING

Durham, North Carolina, 27710-4000, United States

Contact Phone: •••-•••-••••
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, Guangdong, 510120, China

Contact Phone: •••-•••-••••
Hadassah Medical Center- Ein Kerem - PPDS
RECRUITING

Jerusalem, Jerusalem, 90000, Israel

Contact Phone: •••-•••-••••
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada

Contact
Heart Hospital of Austin
RECRUITING

Austin, Texas, 78756-4080, United States

Contact
Hospital Nuestra Señora de Valme
RECRUITING

Seville, 41014, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Virgen de La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain

Contact Phone: •••-•••-••••
Hyogo Prefectural Harima-Himeji General Medical Center
RECRUITING

Himeji-Shi, Hyōgo, 672-8044, Japan

Contact Phone: •••-•••-••••
IPR-Investigaciones en Patologías Respiratorias
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000IAP, Argentina

Contact Phone: •••-•••-••••
IRCCS Policlinico San Donato
RECRUITING

San Donato Milanese, Lombardy, 20097, Italy

Contact Phone: •••-•••-••••
Inha University Hospital
RECRUITING

Junggu, Incheon Gwang'yeogsi, 22332, South Korea

Contact Phone: •••-•••-••••
Instituto Cardiovascular de Rosario - ICR
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina

Contact Phone: •••-•••-••••
Instituto Médico DAMIC
RECRUITING

Córdoba, Córdoba Province, X5003DCE, Argentina

Contact Phone: •••-•••-••••
Instituto de Investigaciones Clínicas Zárate
RECRUITING

Zárate, Buenos Aires, B2800DGH, Argentina

Contact Phone: •••-•••-••••
John Radcliffe Hospital
RECRUITING

Oxford, OX3 9DU, United Kingdom

Contact Phone: •••-•••-••••
Kaplan Medical Center
RECRUITING

Rehovot, 76100, Israel

Contact Phone: •••-•••-••••
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea

Contact Phone: •••-•••-••••
Kishiwada Tokushukai Hospital
RECRUITING

Kishiwada, Osaka, 596-0042, Japan

Contact Phone: •••-•••-••••
Laurelton Heart Specialist PC - MyClinical - PPDS
RECRUITING

Rosedale, New York, 11422-1320, United States

Contact Phone: •••-•••-••••
Leeds General Infirmary - PPDS
RECRUITING

Leeds, Yorkshire, LS1 3EX, United Kingdom

Contact Phone: •••-•••-••••
Local Institution - 0001
ACTIVE_NOT_RECRUITING

Tullahoma, Tennessee, 37388-8260, United States
Local Institution - 0003
ACTIVE_NOT_RECRUITING

Miami, Florida, 33133-4223, United States
Local Institution - 0006
WITHDRAWN

Krakow, 30-082, Poland
Local Institution - 0009
COMPLETED

Bergamo, 24127, Italy
Local Institution - 0010
COMPLETED

Valencia, 46010, Spain
Local Institution - 0011
WITHDRAWN

Montreal, Quebec, H1T 1C8, Canada
Local Institution - 0012
COMPLETED

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Local Institution - 0014
WITHDRAWN

Atlanta, Georgia, 30322-1013, United States
Local Institution - 0017
COMPLETED

Pisa, Tuscany, 56126, Italy
Local Institution - 0019
COMPLETED

Naples, Campania, 80131, Italy
Local Institution - 0020
WITHDRAWN

Lublin, Woj. Lubelskie, 20090, Poland
Local Institution - 0023
WITHDRAWN

Milan, Lombardy, 20162, Italy
Local Institution - 0024
WITHDRAWN

Oświęcim, 51162, Poland
Local Institution - 0025
COMPLETED

Majadahonda, Madrid, 28222, Spain
Local Institution - 0026
COMPLETED

Madrid, 28034, Spain
Local Institution - 0027
WITHDRAWN

Foggia, Apulia, 71100, Italy
Local Institution - 0030
WITHDRAWN

Toronto, Ontario, M5S 1B2, Canada
Local Institution - 0031
COMPLETED

Bialystok, Podlaskie Voivodeship, 15-276, Poland
Local Institution - 0032
ACTIVE_NOT_RECRUITING

Málaga, 29010, Spain
Local Institution - 0033
WITHDRAWN

Milan, Lombardy, 20162, Italy
Local Institution - 0034
WITHDRAWN

Madrid, 28034, Spain
Local Institution - 0035
WITHDRAWN

Trois-Rivières, Quebec, G9A 1Y1, Canada
Local Institution - 0038
WITHDRAWN

Foggia, Apulia, 71100, Italy
Local Institution - 0039
WITHDRAWN

El Palmar, Murcia, 30120, Spain
Local Institution - 0040
WITHDRAWN

Toronto, Ontario, M5S 1B2, Canada
Local Institution - 0041
WITHDRAWN

Oklahoma City, Oklahoma, 73135-2607, United States
Local Institution - 0042
WITHDRAWN

Málaga, Málaga, 29010, Spain
Local Institution - 0043
WITHDRAWN

St Louis, Missouri, 63136, United States
Local Institution - 0044
WITHDRAWN

Bialystok, Podlaskie Voivodeship, 15-276, Poland
Local Institution - 0045
WITHDRAWN

Indianapolis, Indiana, 46260-1992, United States
Local Institution - 0046
WITHDRAWN

Seville, 41014, Spain
Local Institution - 0047
WITHDRAWN

Majadahonda, Madrid, 28222, Spain
Local Institution - 0048
WITHDRAWN

Atlanta, Georgia, 30322-1013, United States
Local Institution - 0049
WITHDRAWN

Lublin, Woj. Lubelskie, 20090, Poland
Local Institution - 0050
WITHDRAWN

San Donato Milanese, Lombardy, 20097, Italy
Local Institution - 0051
WITHDRAWN

Houston, Texas, 77025-5253, United States
Local Institution - 0052
WITHDRAWN

Massa, Tuscany, 54100, Italy
Local Institution - 0057
WITHDRAWN

Sheffield, Yorkshire, S5 7AU, United Kingdom
Local Institution - 0058
WITHDRAWN

Cincinnati, Ohio, 45242, United States
Local Institution - 0066
WITHDRAWN

Falls Church, Virginia, 22042-1262, United States
Local Institution - 0068
WITHDRAWN

Buenos Aires, C1179AAB, Argentina
Local Institution - 0097
NOT_YET_RECRUITING

Dundee, DD1 9SY, United Kingdom

Contact
Local Institution - 0105
NOT_YET_RECRUITING

Brooklyn, New York, 11215, United States

Contact
Local Institution - 0107
WITHDRAWN

Zárate, Buenos Aires, B2800DGH, Argentina
Local Institution - 0117
NOT_YET_RECRUITING

Hackensack, New Jersey, 07601, United States

Contact
Medicus MFC Inc.
RECRUITING

Toronto, Ontario, M4P 1E4, Canada

Contact Phone: •••-•••-••••
National Hospital Organization Kanazawa Medical Center
RECRUITING

Kanazawa, Ishikawa-ken, 920-8650, Japan

Contact Phone: •••-•••-••••
New Cross Hospital
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom

Contact Phone: •••-•••-••••
North Tyneside General Hospital
RECRUITING

North Shields, Northumberland, NE29 8NH, United Kingdom

Contact Phone: •••-•••-••••
Northwick Park Hospital
RECRUITING

Harrow, Greater London, HA1 3UJ, United Kingdom

Contact Phone: •••-•••-••••
Okayama Rosai Hospital
RECRUITING

Okayama, Okayama-ken, 702-8055, Japan

Contact Phone: •••-•••-••••
Peking Union Medical College Hospital - East Campus
RECRUITING

Beijing, Beijing Municipality, 100730, China

Contact
Pusan National University Hospital
RECRUITING

Pusan, Busan Gwangyeogsi, 49241, South Korea

Contact Phone: •••-•••-••••
Rabin Medical Center - PPDS
RECRUITING

Petah Tikva, 49100, Israel

Contact Phone: •••-•••-••••
Rambam Health Care Campus - PPDS
RECRUITING

Haifa, 3109601, Israel

Contact Phone: •••-•••-••••
Rochester General Hospital Center for Clinical Research
RECRUITING

Rochester, New York, 14621, United States

Contact Phone: •••-•••-••••
Samsung Medical Center
RECRUITING

Seoul, 6351, South Korea

Contact Phone: •••-•••-••••
Sanatorio Duarte Quirós
RECRUITING

Córdoba, X5000AOQ, Argentina

Contact Phone: •••-•••-••••
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Gyeonggido, 13620, South Korea

Contact Phone: •••-•••-••••
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea

Contact
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, Seoul Teugbyeolsi, 03722, South Korea

Contact Phone: •••-•••-••••
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel

Contact Phone: •••-•••-••••
Shamir Medical Center
RECRUITING

Be’er Ya‘aqov, 7033001, Israel

Contact Phone: •••-•••-••••
Soroka University Medical Centre
RECRUITING

Beersheba, 84101, Israel

Contact Phone: •••-•••-••••
South Oklahoma Heart Research
RECRUITING

Oklahoma City, Oklahoma, 73135-2607, United States

Contact Phone: •••-•••-••••
St Thomas' Hospital
RECRUITING

London, SE1 7EH, United Kingdom

Contact Phone: •••-•••-••••
St. Louis Heart and Vascular
RECRUITING

St Louis, Missouri, 63136-6111, United States

Contact Phone: •••-•••-••••
Takatsuki Red Cross Hospital
RECRUITING

Takatsuki-Shi, Osaka, 569-1045, Japan

Contact Phone: •••-•••-••••
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 06591, South Korea

Contact Phone: •••-•••-••••
The First Affiliated Hospital of Henan Science and Technology University - Jinghua Campus
RECRUITING

Luoyang, Henan, 471003, China

Contact Phone: •••-•••-••••
The Second Affiliated Hospital, Zhejiang University School of Medicine - Jiefanglu Campus
RECRUITING

Hangzhou, Zhejiang, 310009, China

Contact Phone: •••-•••-••••
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410011, China

Contact Phone: •••-•••-••••
University Hospital of North Tees
RECRUITING

Stockton-on-Tees, TS19 8PE, United Kingdom

Contact Phone: •••-•••-••••
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States

Contact
University of Miami FL Miller School of Medicine -1120 NW 14th St
RECRUITING

Miami, Florida, 33136-2107, United States

Contact
University of Rochester Medical Center - PPDS
RECRUITING

Rochester, New York, 14618-2668, United States

Contact Phone: •••-•••-••••
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

Contact Phone: •••-•••-••••
Weill Cornell Medicine
RECRUITING

New York, New York, 10065-4805, United States

Contact
ZIV Medical Center
RECRUITING

Safed, 1311001, Israel

Contact Phone: •••-•••-••••

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