One shot to tackle two heart risks? new combo drug enters human trials

NCT ID NCT07610278

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This Phase 2 trial tests a new drug called HDY015, which combines two medicines (QCZ484 and inclisiran) into a single injection. The goal is to see if it can safely lower both blood pressure and cholesterol in people who have both conditions. About 120 adults aged 18-75 with hypertension and high cholesterol will receive either the combo, one of the drugs alone, or a placebo, and be followed for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HDY015 (a combination of QCZ484 and inclisiran)
What this could lead to: If successful, this could lead to a single-dose treatment that controls both high blood pressure and high cholesterol, reducing the need for multiple daily pills.
What could go wrong: This is an early Phase 2 study with only 120 participants, so results may not apply to everyone. The combination may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential hypertension Hypercholesterolemia hypercholesterolemia, familial, 1 hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLAEMIA

Contacts and locations

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Locations

ALL Medical Research LLC
RECRUITING

Cooper City, Florida, 33024, United States
AMR Chicago
RECRUITING

Niles, Illinois, 60714, United States
AMR Miami
RECRUITING

Coral Gables, Florida, 33134, United States
Alliance for Multispecialty Research
RECRUITING

Wichita, Kansas, 67207, United States
American Research Centers of FL
RECRUITING

Pembroke Pines, Florida, 33027, United States
Anderson Medical Research
RECRUITING

Ft. Washington, Maryland, 20744, United States

Contact Email: •••••@•••••
Capitol Cardiology Associates
RECRUITING

Lanham, Maryland, 20706, United States
Clinical Research of Brandon LLC
RECRUITING

Brandon, Florida, 33511, United States
Clinical Trials Research
RECRUITING

Lincoln, California, 95648, United States
Dominion Medical Associates
RECRUITING

Richmond, Virginia, 23219, United States
Downtown L A Research Center Inc
RECRUITING

Los Angeles, California, 90017, United States
East Coast Inst for Research LLC
RECRUITING

Saint Augustine, Florida, 32086, United States
East Coast Institute for Research
RECRUITING

Jacksonville, Florida, 32216, United States
East Coast Research
RECRUITING

Canton, Georgia, 30114, United States
Entrust Clinical Research
RECRUITING

Miami, Florida, 33176, United States
Flourish Medical Clinical Trials
RECRUITING

Boca Raton, Florida, 33434, United States
G and L Research LLC
RECRUITING

Foley, Alabama, 36535, United States

Contact Email: •••••@•••••
Great Lakes Clinical Trials
RECRUITING

Chicago, Illinois, 60640, United States
Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
Manassas Clinical Research Center
RECRUITING

Manassas, Virginia, 20110, United States
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
Monroe Research Llc
RECRUITING

West Monroe, Louisiana, 71291, United States
Synergy Group Medical LLC
RECRUITING

Houston, Texas, 77061, United States
Synergy Group Medical LLC
RECRUITING

Houston, Texas, 77061, United States
The Center for Clinical Trials
RECRUITING

Saraland, Alabama, 36571, United States
Universal Axon Clinical Research
RECRUITING

Doral, Florida, 33166, United States
Valley Clinical Trials
RECRUITING

Northridge, California, 91325, United States
Walker Family Care
RECRUITING

Little River, South Carolina, 29566, United States

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