Hypertensive disorder

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study looks at whether the medication Entresto (sacubitril/valsartan) helps Japanese patients with essential hypertension achieve blood pressure targets recommended by Japanese guidelines. Researchers will analyze electronic medical records from a large database, focusing on…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This trial tests whether a short, structured counseling method called BATHE can help people with high blood pressure stick to their treatment plan. Adults with hypertension are randomly assigned to receive either the BATHE interview during clinic visits or standard advice on medi…

This study tested a generic version of the blood pressure drug nifedipine against the brand-name version in 50 adults with mild-to-moderate high blood pressure in Colombia. The goal was to see if the generic pill controls blood pressure just as well after 8 weeks. Participants ha…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can w…

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This clinical trial is testing whether two experimental oral medications, AD-224A and AD-224B, can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). About 254 participants will take one of the drugs or a placebo once dail…

This study tested two different blood pressure tracking systems on smartphones to see if they help older adults take their medication regularly. About 200 people aged 65 and older with high blood pressure used one of the systems for six months. The goal was to see if one system i…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial investigates whether a 10-week Zumba-based exercise program can help lower blood pressure in adults with hypertension. Participants will either join three 50-minute Zumba sessions per week or maintain their usual lifestyle. Researchers will also measure changes in body…

This study tests a new preservative-free eye drop combination (QLS-111-FDC) to lower eye pressure in people with open-angle glaucoma or ocular hypertension. About 60 adults with mild to moderate disease will receive the treatment. The goal is to see if it safely reduces eye press…

This trial tests whether a six-session behavioral program that combines standard hypertension self-management with climate change awareness and heatwave preparedness can improve quality of life, reduce psychological distress, and lower blood pressure in adults with high blood pre…

This study looked at whether combining two types of strength training (dynamic and isometric) can lower blood pressure more than doing just one type. Researchers studied 60 middle-aged adults with high blood pressure who were already on medication. Participants did different exer…

This trial tests whether a single drop of timolol maleate, given just before Nd:YAG laser capsulotomy, can prevent a short-term rise in eye pressure. The study includes adults who developed clouding of the lens capsule months after cataract surgery. Half receive the timolol drop;…

This trial tests whether providing health education materials and a home blood pressure monitor can help Somali community members in the Greater Mankato area better identify, manage, and prevent high blood pressure. Participants receive simple tools and guidance on diet, exercise…

This study looked at two strategies to help Ugandans living with HIV and high blood pressure get better care. One strategy provided free blood pressure medicines and equipment, while the other added extra staff and support. Over 87,000 patients took part. The goal was to see whic…

This study tests whether teaching people with high blood pressure about the Mediterranean diet can help lower their blood pressure and improve their quality of life. About 70 adults with hypertension will either receive diet education or standard care, and their progress is track…

This study tests whether an artificial intelligence system called optima4BP can improve blood pressure control in people with hypertension. The AI analyzes a patient's medications and recommends the best drug adjustments—adding, removing, replacing, or changing doses. Researchers…

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This phase 3 trial tests whether adding Sacubitril/Allisartan to amlodipine can lower blood pressure more effectively than amlodipine alone in people with essential hypertension. Participants are adults aged 18–75 whose blood pressure remains high despite taking amlodipine. The s…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This phase 3 trial tests whether adding amlodipine to Sacubitril/Allisartan can lower blood pressure more effectively than Sacubitril/Allisartan alone in people with essential hypertension. Participants whose blood pressure remains high after four weeks on Sacubitril/Allisartan a…

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This phase 2 trial tests whether a new combination pill, QR12000, can lower blood pressure more effectively than existing medications in people with moderate to severe essential hypertension. Participants are randomly assigned to receive either QR12000, one of its components, or …

This study investigates whether a 12-week moderate aerobic exercise program can improve brain function, cardiovascular health, and cognition in sedentary adults aged 45-65 with borderline or stage 1 hypertension. Participants are randomly assigned to either aerobic exercise or a …

This study tests whether a new generic tablet containing selexipag works the same as the brand-name drug Uptravi. Healthy adults aged 18 to 55 take a single dose of each version under fed conditions, and researchers compare how much drug gets into the bloodstream. The goal is to …

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This pilot study tests whether the DASH diet, lifestyle advice, or a combination of both can lower blood pressure in adults with prehypertension—a condition where blood pressure is higher than normal but not yet in the high blood pressure range. Researchers randomly assigned 32 p…

This early-stage study tested a new drug called QCZ484 in 56 healthy volunteers and people with mild hypertension. The main goal was to check safety and how the body handles the drug. Participants received a single injection of either QCZ484 or a placebo, and researchers monitore…

This study tests whether a 12-week vinyasa (flow) yoga program done at home via Zoom can improve heart health in people with high blood pressure. Thirty adults with elevated blood pressure will be split into two groups: one does yoga three times a week, the other continues their …

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…

This trial investigates whether a daily dose of olive leaf extract (atherolive) can help control blood pressure and improve cholesterol levels in adults with hypertension. Participants are randomly assigned to receive either the extract or a placebo for three months. The study ai…

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tested a new way to help people with high blood pressure take their medication regularly. Researchers worked with 10 primary care clinics and over 1,700 patients, using a team of doctors, nurses, and medical assistants supported by electronic health records. The goal w…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This trial tests a special pacemaker called the BackBeat Moderato that can adjust its pacing to help control high blood pressure. Researchers will turn the device on and off for short periods in 28 people who already have the pacemaker implanted, measuring how their blood pressur…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested whether community health workers (CHWs) could help adults with high blood pressure who also struggle with food insecurity. 75 participants were assigned to either CHW education alone or CHW education plus extra support like grocery transportation and cooking cla…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This study tested whether giving low-income adults with high blood pressure free fruits and vegetables for 6 months could help lower their blood pressure. 104 participants from West Dallas, Texas received the produce prescription program. Researchers measured blood pressure chang…

This study tested a drug called sotatercept (MK-7962) in 46 Japanese adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took the drug alongside their usual treatments. The main goals were to see if it improve…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study looked at whether giving extra help to clinics (called practice facilitation) improves how well they follow a program to help patients take their blood pressure medicine. The study included 652 Latino adults with uncontrolled high blood pressure who were not taking the…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study tested whether providing home-delivered DASH diet groceries, with help from a dietitian, could lower blood pressure in Black adults living in urban areas with limited access to healthy food. 180 participants with elevated blood pressure but not on medication took part.…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study tested a smartphone app called Elfie to help people with high blood pressure lower their numbers. 930 adults with uncontrolled high blood pressure used the app alongside their usual care or just usual care alone. The goal was to see if the app could help bring down sys…

This study tested whether a stricter blood pressure goal (below 135/85) after a pregnancy complicated by high blood pressure is better than the usual care (below 150/100). About 60 new mothers were enrolled and followed for six months. The goal is to see if tighter control is pos…

This study looked at whether a progressive resistance training program could help older adults with sarcopenia (age-related muscle loss) control their high blood pressure. 77 sedentary adults aged 60 and older participated. The goal was to see if building muscle strength could be…

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a drug called sotatercept in 173 people with severe pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. Participants received either the drug or a placebo on top of their usual treatments. The goal was to see if th…

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This study tested whether a smartphone-based lottery incentive program could help people with high blood pressure take their medication more regularly. Over 400 participants with poorly controlled blood pressure were randomly assigned to receive the lottery program or usual care …

This study looked at whether practicing tai chi—a slow, gentle exercise with deep breathing—could lower blood pressure and improve thinking skills in older adults with high blood pressure. Nineteen participants tried a single session and then a 12-week online tai chi program. Res…

This study tested whether a smartphone app can guide people through a simple breathing exercise to lower systolic blood pressure. 33 adults with elevated blood pressure did 5 minutes of breathing training daily for 6 weeks, either guided by an app or by researchers in a clinic. T…

This study compared two treatments for advanced open-angle glaucoma: a gentle laser (subthreshold diode laser) and a surgical procedure (trabeculotomy). 80 adults with severe glaucoma that was not controlled by maximum medications took part. The goal was to see which treatment be…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This completed study compared two intravenous blood pressure medications, labetalol and hydralazine, in 132 pregnant women with severe preeclampsia. The goal was to see which drug more effectively lowered blood pressure to safe levels. Results could help doctors in the local sett…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This Phase 3 trial tested a new drug called lorundrostat in over 1,000 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. Participants received either lorundrostat or a placebo daily for 12 weeks. The main goal was to see if the drug l…

This study tested an experimental drug called zilebesiran in 36 Japanese adults with mild to moderate high blood pressure. The goal was to see if it is safe and helps lower blood pressure over 6 months. Participants received either the drug or a placebo, and researchers monitored…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This study tested an experimental drug called SLx-2101 in 38 adults with moderate to severe high blood pressure. Participants took either 5 mg or 10 mg of the drug daily for 14 days to see how it affected their blood pressure and heart rate. The goal was to check if the drug is s…

This study tested two different blood pressure targets during cesarean section in 390 women with preeclampsia. One group kept blood pressure above 80% of their starting level, the other above 90%. The goal was to see which target led to better newborn outcomes, measured by umbili…

This study tested whether taking two drugs (DWC202206 and DWC202207) together is safe and effective for people with both high blood pressure and high cholesterol. 214 adults aged 19 to 80 took part. The goal was to see if the combination lowered blood pressure and LDL ("bad") cho…

This study tested a new drug called SLx-2101 in 26 adults with moderate to severe high blood pressure. Participants took the pill once daily for up to 12 days to see how well it lowers blood pressure and if it is safe. The goal is to find the right dose for future studies.

This completed Phase 4 trial tested a single pill containing three medicines (telmisartan, amlodipine, and rosuvastatin) in 252 Korean adults with both high blood pressure and high cholesterol. Participants took either the triple pill or a two-drug pill for 8 weeks. The study mea…

This study tested whether a structured phone call teaching patients about home blood pressure monitoring would increase the number of people who bring their blood pressure logs to doctor visits. 170 adults with uncontrolled high blood pressure took part. The goal was to see if th…

High blood pressure affects nearly half of Americans, but only half have it under control. This study tested whether a digital program—including personalized health coaching and a connected blood pressure cuff used via smartphone or website—could improve blood pressure control co…

This study looked at the safety of using levosimendan over a longer period in people who have both pulmonary hypertension and heart failure with preserved ejection fraction. 35 patients who had already been in a related study received the drug and were monitored for side effects.…

This study tested a single intravenous infusion of stem cells from donated umbilical cord tissue in one person with severe scleroderma that had caused lung scarring and high blood pressure in the lungs. The goal was to see if the treatment could improve lung function, exercise ab…

This study looked at whether giving people home blood pressure monitors and teaching them to use online portals and texting with their doctors can help them better control their high blood pressure. Over 500 adults with uncontrolled hypertension took part for 12 months. The goal …

This completed study tested whether combining valsartan and hydrochlorothiazide works better than valsartan alone for people with hypertensive heart disease. 118 adults aged 18-70 took part over 8 weeks. Researchers measured blood pressure, heart changes on ECG, and symptoms to s…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether a peanut-based nutritional supplement could improve health in adults aged 60 and older living in peri-urban Ghana. Over 12 weeks, 81 participants either took the supplement daily or served as a control group. Researchers measured weight, blood pressure, …

This early-stage study tested a single injection of ART101 in 40 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. The goal is to gather initial safety data before testing in people with high blood pressure.

This study tested whether the drug sotatercept, given for 36 weeks, improves how the heart and lungs work during exercise in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH received injections of sotatercept. Researchers measured heart pressure, blood fl…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study looked at whether visits from parish nurses (faith community nurses) can help people with high blood pressure lower their numbers. Researchers recruited 100 adults from church health fairs in Los Angeles and randomly assigned them to either nurse visits or regular doct…

This early-stage trial tested the safety and tolerability of telpegfilgrastim injections in 18 non-pregnant women, including some with a history of preeclampsia. Researchers monitored side effects, drug levels in the blood, and immune markers. The goal is to see if the drug is sa…

This study looked at how the drug CS1 changes the structure of small lung arteries in people with pulmonary arterial hypertension (PAH). Seven patients already taking CS1 in an expanded access program had special CT scans at the start and after 12 months. The goal was to see if C…

This study tested whether support from a significant other—like a spouse or family member—can help people with hypertension follow their medication and lifestyle recommendations. 133 participants and their significant others took part. The significant others used strategies like …

This phase 2b trial tested an inhaled powder form of treprostinil palmitil in 102 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. The study compared the drug to a placebo to see if it could lower lung…

This study tested a 12-week food as medicine program for 159 adults with high blood pressure and food insecurity. Participants received either a $100 monthly grocery card or 5 medically tailored frozen meals per week. Researchers measured changes in blood pressure and diet to see…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study tested whether a smartphone app and home blood pressure monitor could help doctors personalize the dose of the blood pressure drug Zestril for each patient without needing in-person visits. Twenty adults with uncomplicated high blood pressure participated. The goal was…

This study tested whether eating dark chocolate (72% cocoa) daily for two weeks could lower blood pressure and a heart risk marker in men with mild hypertension. Fifty-three Thai men ate either dark or white chocolate each day, then switched after a week off. The goal was to see …

This completed study gave 580 Native American adults and children in Osage Nation weekly boxes of fresh fruits and vegetables along with healthy recipes and cooking classes. The goal was to see if this program could improve diet, lower blood pressure, and reduce health risks like…

This study looked at 70 people with mild to moderate glaucoma or high eye pressure. All received a laser treatment called selective laser trabeculoplasty (SLT). Afterward, half used Rocklatan eye drops and half used artificial tears. The goal was to see if Rocklatan lowered eye p…

This Phase 3 trial tested whether adding a third drug (DWC202314) to a two-drug combination pill works better for people with essential hypertension that isn't controlled by the two-drug pill alone. 198 participants took either the two-drug or three-drug combination once daily. T…

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested a mobile app called Collabree to see if it helps people over 50 with high blood pressure take their medication more regularly. 144 participants used the app for 90 days and were followed for another 90 days. The app sent reminders and used behavioral tricks to e…

This study tested whether a mobile app called Collabree could help people with high blood pressure take their medication more regularly. 181 adults in Switzerland who took at least 4 blood pressure pills daily participated. They were randomly assigned to use the app or receive st…

This completed study tested whether community health workers (CHWs) and home blood pressure monitoring could help adults in rural South Africa control their high blood pressure. Over 770 participants were assigned to different levels of CHW support. The goal was to see if this ap…

This completed pilot study tested whether a very low-carbohydrate diet could lower blood pressure in 64 lower-income African American adults with high blood pressure. Participants followed either a low-carb or standard low-fat diet for 10 months. Researchers measured changes in b…

This study tested a mobile app called USeeBP in 31 African American adults with poorly controlled high blood pressure. Participants used the app alongside their usual remote monitoring program to track blood pressure readings at home. The goal was to see if the app could help imp…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study tested a low-cost tool to help health workers in Mozambique better diagnose and manage high blood pressure in people with HIV. The tool uses cycles of evaluation and improvement to streamline care. Researchers worked with 18 health facilities to see if this approach co…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This completed trial tested a new, noninvasive device that uses focused ultrasound to destroy a small amount of fat around the kidney. The goal was to lower blood pressure in people with mild hypertension who were not taking medication. 79 participants were randomly assigned to r…

This study tested a personalized education program called 'Mi Propio Camino' (My Own Way) to help Hispanic adults with uncontrolled high blood pressure stick to their medication. Over 500 participants received either the tailored program or standard care. The goal was to see if p…

This study looked at whether adding paced or diaphragmatic breathing to mat Pilates can improve heart and lung fitness, reduce shortness of breath, lower stress and anxiety, and boost quality of life in people with stage II high blood pressure. Sixty-three adults aged 40 to 50 to…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested two drugs, levosimendan and dobutamine, in 52 adults undergoing heart valve replacement. The goal was to see which one better preserves right ventricular function after surgery. Patients were randomly assigned to receive one of the drugs, and their heart functio…

This completed trial tested whether giving a low-sodium salt substitute to 309 households in rural Bangladesh could lower blood pressure. Community health workers delivered the salt and provided education on high blood pressure and salt intake. The study measured changes in blood…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study looked at whether a combination drug (sacubitril/valsartan) can stop atrial fibrillation from returning after a heart procedure called catheter ablation. The study included 320 older adults (ages 55-80) with high blood pressure and atrial fibrillation. Participants too…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This study tested a drug called riociguat in 10 adults who still had trouble exercising at least 6 months after surgery for chronic blood clots in the lungs. The goal was to see if the drug could improve blood pressure in the lungs and make exercise easier. Participants took the …

This study tested an inhaled medication called treprostinil in 5 people with sarcoidosis who also have lung scarring and high blood pressure in the lungs. The goal was to see if the drug could improve blood flow and heart function. Participants took the drug and were monitored wi…

This study tested whether drinking rosemary tea for 45 days can lower blood pressure in men with mild hypertension. Fifty-four men participated, with half drinking rosemary tea and half a placebo. The researchers measured blood pressure and checked how rosemary affects a key enzy…

This study tested a nurse-guided phone program for 500 recent stroke patients in Ghana to help them manage their blood pressure at home. The program included home blood pressure monitoring, medication reminders, and education on heart health. The goal was to see if this approach …

This study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The …

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This study tested a culturally-tailored program called HARMONY for African American women at risk for heart disease, stroke, and diabetes. Over 8 sessions plus monthly boosters, participants learned stress management, exercise, and healthy eating. The goal was to see if the progr…

This study looked at 30 adults who had brain surgery after a hemorrhagic stroke and needed blood pressure control in the ICU. Researchers compared two IV medicines, nicardipine and labetalol, to see which one better controlled blood pressure and heart rate during the first 24 hou…

This study tested the drug dapagliflozin (used for diabetes and heart failure) in 52 adults with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension. The goal was to see if it improves exercise capacity and heart function. Participants took the …

This study tested an experimental drug called lorundrostat in 285 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. The drug works by blocking a hormone that raises blood pressure. Researchers measured how much it lowered blood pressu…

This study tested whether drinking rosemary infusion daily for 6 weeks could help people with mild high blood pressure and high triglycerides. 47 adults took part, and researchers measured blood pressure and blood fats before and after. The goal was to see if this simple herbal d…

This pilot study tested a procedure called pulmonary artery denervation (PADN) in 30 adults with combined high blood pressure in the lungs and chronic heart failure. The procedure uses radiofrequency energy to disrupt certain nerves in the lung's blood vessels, aiming to lower pr…

This study tested a new eye drop called SBI-100 in 56 adults with glaucoma or high eye pressure. Participants received either a low dose, high dose, or placebo drop twice daily for 14 days. Researchers measured how well the drops lowered eye pressure and checked for side effects.

This completed pilot study tested whether a special diet made from tartary buckwheat could help lower blood pressure in 130 adults with mild hypertension. Participants added the buckwheat formulation to their regular meals and were compared to those receiving standard care. The s…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested whether training female community health volunteers (FCHVs) to lead group meetings and support can help people with high blood pressure in rural Nepal. 520 adults aged 30-75 with high blood pressure took part across 12 health facilities. The volunteers were trai…

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to regular home visits for new moms and their babies. About 150 mothers who had Medicaid and recently gave birth took part. The goal was to see if the program could help moms manage weight,…

This completed study tested two different blood pressure treatments in 59 adults under 60 who were newly diagnosed with hypertension. One group took bisoprolol alone, while the other took a combination pill containing valsartan and amlodipine. The goal was to see which approach b…

This study looked at whether it is safe to reduce blood pressure medication in frail older adults living in long-term care. Researchers enrolled 522 residents with low blood pressure and tested a gradual medication reduction plan. The goal was to see if this approach could lower …

This study tested two different laser treatment locations for open-angle glaucoma: one targeting the nasal side of the eye and one targeting the inferior side. 13 patients received the laser procedure to see which location better lowers eye pressure. The goal is to find the most …

This completed Phase 2 trial tested two strengths of a new eye drop called T4090 against the existing drug Rhopressa in 161 adults with open-angle glaucoma or ocular hypertension. The goal was to see which better lowers eye pressure over 7 weeks. Participants used one drop daily …

This study tested whether hydroxytyrosol, a natural antioxidant found in olives, can reduce inflammation and oxidative stress in pregnant women with high blood pressure. 42 women took either a daily 10 mg hydroxytyrosol capsule or a placebo for 4 weeks. Researchers measured chang…

This study tested a black seed extract (Nisatol®) in 50 perimenopausal women with metabolic syndrome, a cluster of conditions like high blood sugar and blood pressure. Over 4 months, researchers measured changes in blood sugar, cholesterol, blood pressure, and menopausal symptoms…

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study looked at whether adding community health workers to regular care helps people with type 2 diabetes and high blood pressure in rural Mexico take their medicines as prescribed. 168 adults from local clinics took part. Researchers measured changes in blood sugar and bloo…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This study tested a new medicine called ALN-AGT01 in 394 adults with mild-to-moderate high blood pressure. The goal was to see if it could safely lower blood pressure over three months. Participants received either the drug or a placebo, and blood pressure was measured continuous…

This study tested whether Pilates or circuit exercise training could help lower blood pressure and improve cholesterol levels in 69 pregnant women with gestational hypertension. All women also received standard blood pressure medication. The exercises were done three times a week…

This study tested whether doing wall squat exercises can help lower blood pressure in Chinese adults with hypertension. 50 participants who were not very active were randomly assigned to either a wall squat group or a stretching group for 24 weeks. The main goal was to see how ea…

This study tested whether a special exercise program could help people with high blood pressure, especially those whose blood pressure doesn't drop enough during sleep (a condition linked to higher heart risks). 198 Chinese adults who did little exercise were split into two group…

This study looked at 200 women with eclampsia (a serious condition causing seizures during pregnancy) to see if giving magnesium sulphate into a vein (IV) or into a muscle (IM) works better to stop seizures from coming back. Women were randomly assigned to one of two treatment gr…

This study tested whether having patients with uncontrolled high blood pressure monitor their own blood pressure at home could help lower it. 70 adults with hypertension were split into two groups: one group used a home monitor for 5 days each month, while the other group did not…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study tested whether a device that gently stimulates a nerve in the ear (vagus nerve) can help control blood pressure during heart stent placement. 480 adults with coronary artery disease and high blood pressure were randomly assigned to receive either real or sham stimulati…

This study tested whether doing simple isometric exercises (pulling a band at 30% effort for 2 minutes) 1, 2, or 3 times a week can lower blood pressure in people with borderline or high blood pressure. 30 adults who were not on medication participated. The goal was to find the s…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tested a non-invasive device worn on the finger to continuously measure blood pressure in children during surgery. Researchers compared its readings to those from an arterial line, the standard method that requires a needle. If proven accurate, this device could offer …

This trial checks whether a wrist-worn blood pressure monitor (Model: RIV-B10) can measure blood pressure as accurately as the traditional arm cuff and mercury device. About 158 adults aged 18 and older with wrist sizes between 13 and 21 cm will have their blood pressure taken wi…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study looks at whether measuring the optic nerve sheath (the lining around the nerve connecting the eye to the brain) combined with blood tests for angiogenic factors can better diagnose severe pre-eclampsia in pregnant women. Pre-eclampsia is a serious condition that can ha…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study tests whether a new device called VicorderCS can measure blood pressure accurately. The device uses a standard arm cuff and is designed to be faster and more portable than older models. Researchers will compare its readings to those taken with a traditional stethoscope…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested an AI tool called VeriSee GLC that analyzes color images of the back of the eye to find signs of glaucoma. Researchers looked at 773 adults' existing eye images to see how well the AI could identify people who might have glaucoma, comparing its results to a pane…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study tested a device called ShuntCheck, which uses a mild heat sensor on the skin to see if a brain shunt is flowing properly. Researchers enrolled 12 adults with pseudotumor cerebri who had a shunt placed and were feeling well. The goal was to see if the device could corre…

This study looked at whether measuring homocysteine levels in the blood can help predict how severe preeclampsia will become in pregnant women. Researchers measured homocysteine in 70 critically ill preeclampsia patients and analyzed its link to complications. The goal is to see …

This completed study looked at whether measuring blood flow in the fetal lung artery using ultrasound can predict breathing difficulties in newborns. Researchers studied 86 pregnant women with severe preeclampsia between 28 and 37 weeks. The goal was to see if a specific ultrasou…

This study tested a new smart contact lens called miLens that records eye pressure patterns over 24 hours in 86 adults with glaucoma and healthy volunteers. Participants wore the lens in one eye and took smartphone readings every 15 minutes while awake. Researchers compared the l…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study looked at whether a protein called Cadherin-6 in the blood of pregnant women could help predict preeclampsia, a dangerous condition involving high blood pressure. Researchers measured Cadherin-6 levels in 150 women between 15 and 20 weeks of pregnancy and tracked who l…

This study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…

This study checked how well the Withings BPM Pro 2, an automatic blood pressure cuff, measures blood pressure compared to a standard manual device. 89 adults had their blood pressure taken with both devices. The goal was to see if the Withings cuff is accurate enough for home use…

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This trial tests whether screening for chronic kidney disease (CKD) in trusted community settings, like churches, can identify people with early kidney damage who don't yet have symptoms. Participants are adults aged 18-70 without known kidney disease who attend community health …

This study tests whether taking a daily vitamin D supplement (4000 IU) can lower the chance of preeclampsia returning in pregnant women who have had it before. Researchers will randomly assign 146 women to receive either vitamin D or a placebo from enrollment until 36 weeks of pr…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This pilot study tested whether ready-to-eat meals based on the DASH diet could help lower blood pressure and reduce heart disease risk. Twenty adults ate the prepackaged meals daily for 4 weeks while researchers monitored their blood pressure and weight. The goal was to see if a…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether a community-based program offering flexible HIV prevention and treatment options could lower the number of new HIV infections. Over 80,000 people aged 15 and older in East African communities took part. The approach focused on delivering the right care t…

This study trained community health workers to screen Black men for early signs of high blood pressure. Participants received lifestyle advice and were connected to doctors and social services. The goal was to prevent hypertension from getting worse.

This study tested a school program called 'High Five!' to see if it could help prevent overweight and obesity in children aged 7 to 9. Over 650 children took part in fun lessons about healthy eating, physical activity, screen time, and sleep. The program also involved parents to …

This study tested whether taking a low-dose aspirin (160 mg) each night, starting before 16 weeks of pregnancy, could prevent pre-eclampsia and small babies in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery were randomly assigned …

This pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …

This study looked at how aspirin affects platelet function in 130 pregnant women at high risk for preeclampsia. Researchers measured platelet response and genetic factors to see if they could predict who develops high blood pressure disorders. The goal is to eventually personaliz…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…

This study tested whether soaking your legs in hot water after a 30-minute walk can lower blood pressure better than exercise or heat alone. Twenty adults with slightly high blood pressure completed four different sessions: walking plus a lukewarm bath, walking plus a hot bath, h…

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study tested whether placing elderly patients (ages 65-80) with high blood pressure in a lithotomy (legs-up) position for two minutes before anesthesia could prevent a dangerous drop in blood pressure. Sixty patients were randomly assigned to either the legs-up position or t…

This study tested two non-drug therapies—graded motor imagery (mental rehearsal) and mirror therapy (using a mirror to trick the brain)—in 44 chronic stroke patients aged 45 to 65. The goal was to see which better reduces muscle spasticity and improves independence. Both therapie…

This study looked at whether adding virtual reality (VR) and classical music to standard blood pressure medication can help people who come to the emergency room with very high blood pressure (hypertensive urgency). 130 adults with high blood pressure but no organ damage were ran…

This study compared two types of nerve blocks—erector spinae plane block and paravertebral block—for pain control after open kidney surgery. 72 adults were randomly assigned to one of the two blocks. Researchers measured pain scores, opioid use, and vital signs during the first 2…

This pilot study tested a remotely delivered self-management program called TEAM-Red for depressed young African American women who also have risk factors for high blood pressure. 83 women participated in group video sessions over 12 weeks, with researchers tracking changes in de…

This study looked at whether giving a sedative called dexmedetomidine before placing a breathing tube can prevent sudden rises in blood pressure and heart rate in patients with controlled high blood pressure. 70 adults having planned surgery under general anesthesia took part. Th…

This completed pilot study looked at whether yoga can help African American adults with high blood pressure manage stress and remember to take their medication. Eight participants attended weekly yoga sessions for 8 weeks. Researchers measured blood pressure, stress levels, and t…

This study tested an inhaled medication called RT234 in 14 adults with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is dangerously high. The goal was to see if the drug could quickly lower lung blood pressure during a heart catheterization …

This study tested whether briefly cutting off blood flow to the legs (ischemic preconditioning) before resistance exercise could lower heart strain in women aged 60 and older. Thirty physically active older women did two exercise sessions—one with the real cuff procedure and one …

This study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The g…

This study tested whether acupuncture or deep breathing exercises could help lower blood pressure in pregnant women with hypertension during their third trimester. Forty women aged 25-35 took part. The goal was to find safe, non-drug options for managing high blood pressure in pr…

This study tested a self-management app for women who had high blood pressure during pregnancy. 99 new mothers used the app to track their blood pressure, stress, and mood, or received usual care. The goal was to see if the app helps lower blood pressure and improve mental health…

This study tested a dynamic blended learning module for 49 people with pulmonary hypertension, a chronic disease causing symptoms like shortness of breath and fatigue. The program included face-to-face education, regular phone follow-ups, and a video from a patient who successful…

This study looked at whether two easy breathing exercises—Liuzijue (a gentle Chinese practice using sounds) and box breathing (a controlled pattern)—can improve lung capacity and blood pressure in older adults who were immobile after a hip fracture. Researchers analyzed data from…

This study tested two exercise programs—aerobic exercise and physiological ischemic training—in 60 adults with grade 2 high blood pressure. Over 6 weeks, researchers measured changes in blood markers, fitness, muscle strength, and quality of life. The goal is to see which approac…

This study tested two drugs, lignocaine and dexmedetomidine, to see which better prevents sudden rises in heart rate and blood pressure when a breathing tube is inserted during anesthesia. 62 adults having elective surgery took part. The goal is to find a safer way to protect pat…

This study looked at 40 men over 45 with high blood pressure and heart disease to compare two types of exercise: interval training and continuous training, both including aerobic and resistance exercises. The goal was to see which better improves heart function and blood pressure…

This study tested two ways of doing exercise at home for people with high blood pressure. One group exercised with a live physiotherapist on video calls, while the other followed pre-recorded videos. Over 8 weeks, researchers measured changes in exercise capacity, blood pressure,…

This study looked at whether giving extra oxygen to people who live high in the mountains and have high altitude pulmonary hypertension (a type of high blood pressure in the lungs) helps them walk farther. Twenty-four participants completed the trial. Researchers measured how far…

This study tested whether taking peppermint oil by mouth can improve heart health in people with mild to moderate high blood pressure. 40 adults aged 18-65 with systolic blood pressure between 120-139 mmHg and not on blood pressure medication participated. Researchers measured ch…

This study looked at whether exercising in the morning or early evening makes a difference in blood pressure and blood vessel health for postmenopausal women with high blood pressure. Sixty-eight women did walking and handgrip exercises at different times of day. The goal was to …

This study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores…

This study looked at whether doing a mandala coloring activity could lower stress and fear of childbirth in women hospitalized with high-risk pregnancies. 149 pregnant women took part. The researchers measured their anxiety, stress, and fear levels before and after the activity.

This study compared the short-term effects of active video games versus traditional exercise in 16 adults with pulmonary hypertension. Participants did both types of exercise on separate days, and researchers measured heart rate, blood pressure, oxygen levels, and enjoyment. The …

This small study tested a type of talk therapy called Rumination-Focused Cognitive Behavior Therapy (RFCBT) in 9 low-income adults who had both depressive symptoms and high blood pressure. The therapy aims to help people recognize and stop repetitive negative thoughts (rumination…

This study tested whether a 6-week mindfulness program could help people with high blood pressure better follow their medication, diet, and exercise plans. 36 adults who struggled with adherence participated. The goal was to see if mindfulness, which focuses on inner motivation, …

This study tested whether people with pulmonary vascular disease (problems with blood vessels in the lungs) can walk the same distance in 6 minutes without extra oxygen as they can with it. 40 adults who had low oxygen levels during exercise did two walk tests—one breathing norma…

This study looked at 34 adults with acute ischemic stroke and very high blood pressure. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure faster before stroke treatment. The goal was to find the best way to quickly and safely get b…

This study tested whether a short lesson on good sleep habits could improve sleep quality and blood pressure in adults with high blood pressure. 138 people took part, with half receiving the lesson and a sleep diary, and the other half getting usual care. After 8 weeks, researche…

This study looked at 558 adults with mild to moderate sleep apnea who also don't get enough sleep. Researchers compared two programs: one focused on improving use of a PAP machine, and another on sleep education. The goal was to see which works better for reducing daytime sleepin…

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study is testing a chatbot platform called PROMBot that lets people with hypertension report their blood pressure and other health information via text messages. The goal is to see if the chatbot is easy and enjoyable to use, and whether it can help patients stay engaged in …

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study compares two methods of placing a breathing tube during general anesthesia without using opioid painkillers. The goal is to see which method—fiberoptic or direct laryngoscopy—causes less change in heart rate and blood pressure. Researchers will study 90 adults aged 18 …

This study tested how well blood pressure cuffs work on the upper arm, forearm, thigh, and lower leg compared to a standard arterial line. Researchers measured 84 adults during planned surgery. The goal was to see if other sites give accurate readings when the upper arm can't be …

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study looked at 63 women having laparoscopic hysterectomy to see if two different anesthetics (sevoflurane and desflurane) affect pressure inside the head differently. The researchers measured the optic nerve sheath diameter using ultrasound as a non-invasive way to check br…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 30 days could improve gut bacteria, weight, and heart health in 47 healthy adults aged 18-60. Participants were randomly assigned to receive the supplement or a placebo. The goal was to gather i…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This study looks at how steep head-down position and two types of anesthesia (total IV vs. balanced) change eye pressure in women having robotic surgery for gynecologic cancer. Researchers will measure eye pressure in 40 participants to see which anesthesia method causes less pre…

This study tested whether a pop-up alert in electronic health records could increase doctors' recommendations for low-dose aspirin in pregnant women at high risk for preeclampsia. Over 800 women were included, and the alert was shown during prenatal visits. The goal was to see if…

This study looks at how different levels of forced breathing change pressure inside the eye. Researchers will use a special device called Airofit to measure this in 60 healthy adults. The goal is to better understand the link between breathing effort and eye pressure, which could…

This study looked at how sleep, body clocks, and daily habits affect nighttime blood pressure in Black adults. Researchers monitored 30 participants in a lab for a week to measure blood pressure changes. The goal is to find better ways to treat high blood pressure by targeting sl…

This study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study tested a new device called ClearSight NextGen that monitors blood pressure during surgery. It included 35 adults who already had an arterial catheter as part of their care. The goal was to collect blood pressure data to help improve the device's accuracy.

This study investigates how a high-salt diet versus a low-salt diet influences blood pressure and the immune system in middle-aged adults. Participants follow each diet for one week while their blood pressure and inflammatory markers are measured. The goal is to understand why so…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This completed pilot study tested a 6-week web-based program called Mind Your Heart in 37 adults who were university employees. The program combined DASH diet education with mindful eating training to improve eating habits and health measures like blood pressure and cholesterol. …

This study looked at how moderate aerobic exercise affects blood pressure in people with hypertension living in cold regions. Researchers measured changes in blood pressure, heart rate variability, and stress-related markers after 16 weeks of exercise. The goal was to understand …

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study followed 72 adults with pulmonary hypertension caused by chronic lung diseases, like interstitial lung disease, who were treated with inhaled iloprost in routine care. Researchers tracked changes in their risk levels over time using a standard scoring model. The goal w…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study looks at whether the position of a pacemaker lead in the right ventricle can improve how well the BackBeat Moderato system controls blood pressure. Five people with hypertension who already have a pacemaker will have their heart pressures and volumes measured with the …

This study looked at whether using concept maps—diagrams that show how ideas connect—helps third-year medical students learn and remember information better. 26 students were split into three groups: one with no concept map, one with a map made by the teacher, and one where stude…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested whether the Corsano CardioWatch 287-2, a smartwatch that measures blood pressure using light sensors, can accurately track blood pressure changes in people starting or adjusting their blood pressure medication. Eighty adults with uncontrolled high blood pressure…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study looked at how doing isometric (static) exercises with a cuff that limits blood flow affects blood pressure and heart function. Twenty-one healthy young adults did exercises under three conditions: no cuff, a wide rigid cuff, and a narrow elastic band. The goal was to s…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study tested a new strategy for collecting patient-reported outcome measures (PROMs) to make them more relevant and less burdensome. Researchers compared usual PROMs with an enhanced version in 200 English- and Spanish-speaking patients. The goal was to see if the new approa…

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study looked at ways to screen for pulmonary hypertension (high blood pressure in the lungs) in people who already have interstitial lung disease. The goal was to find this complication earlier. 314 adults with various types of lung disease took part in the screening tests.

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how eye pressure changes when breath-hold divers hold their breath. Forty divers had their eye pressure, oxygen levels, heart rate, and blood pressure measured before, during, and after holding their breath. The goal was to understand these changes and how th…

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This study tested a Portuguese version of the DIVA questionnaire to see if it reliably measures how vaginal aging symptoms (like dryness, itching, or pain) affect daily activities, sex life, emotions, and body image. 300 women with at least one symptom of vulvovaginal atrophy too…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This study looked at 57 kidney transplant patients to see if high blood pressure is related to having too much fluid in the body. Patients measured their blood pressure and fluid levels at home between 30 and 90 days after their transplant. The goal was to find a connection that …

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study looked at how the position of a patient's arms during spinal anesthesia affects pressure inside the eye. Sixty adults having hernia repair were randomly placed with arms at their sides or hands on their chest. Eye pressure was measured before and after anesthesia to se…

This study looked at 125 African American adults with high blood pressure to understand what helps them stick to their treatment and stay resilient. Researchers measured blood pressure, quality of life, and self-management behaviors over 6 months. The goal is to find new ways to …

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study looked at whether young men and women respond differently to a simple handgrip exercise for lowering blood pressure. Twenty-nine healthy adults did handgrip training at home for 4 weeks, while researchers measured blood pressure and blood vessel function. The goal is t…

This study looked at whether special ultrasound measurements of the baby's kidney and placenta can help predict health problems in newborns. Researchers compared 114 pregnant women with and without preeclampsia. The goal was to see if these scans could warn doctors about complica…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at how melatonin, a hormone known for sleep and as an antioxidant, changes during pregnancy. Researchers measured melatonin and its main byproduct in the blood of 60 women across each trimester. The goal was to gather basic information to help design larger stud…

This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation pl…

This study tested a special nursing program that teaches pregnant women with preeclampsia about climate-related health risks, like heat and pollution. 104 women took part, with half receiving the program plus usual care and half receiving usual care alone. The goal was to see if …

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study looked at how two different ways of doing resistance exercise (short vs long sets) affect the heart and blood vessels of postmenopausal women, both with and without high blood pressure. Sixty women participated, and researchers measured things like blood pressure, hear…

This study tested a special MRI that uses inhaled xenon gas to take detailed pictures of lung function in people with pulmonary arterial hypertension (PAH). Ten adults with PAH had four scans over 18 weeks to see how their lungs processed the gas. The goal was to find new ways to…

This study compared two non-invasive blood pressure methods—a finger sensor and a standard arm cuff—against the most accurate method, an arterial line, in 80 patients having non-cardiac surgery. The goal was to see which non-invasive method agrees more closely with the arterial l…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study looked at how changing a patient's position during major abdominal cancer surgery affects their heart function and vital signs. Researchers used a non-invasive esophageal Doppler monitor to measure cardiac output in 80 patients undergoing either laparoscopic or open su…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This completed study investigated why low-dose aspirin helps prevent preeclampsia in some high-risk pregnant women but not others. Researchers took blood samples from 35 women at four points during pregnancy to study their immune cells, particularly neutrophils. The goal was to i…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study examined how Ramadan fasting changes blood pressure in 150 healthy adults and people with stable hypertension. Participants had their blood pressure monitored around the clock during the fasting period. The goal was to see if fasting affects blood pressure variability,…

This completed study looked at 500 adults hospitalized with dangerously high blood pressure. Researchers measured levels of the hormone aldosterone to see if it relates to how long patients stay in the hospital or if they have complications. The goal was to better understand the …

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood…

This study looked at how blood pressure and heart rate change in the hour after an epileptic seizure. Researchers measured these vital signs at several time points in 1,100 people with epilepsy. The goal was to better understand the body's response right after a seizure, which ma…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This completed study looked at why some pregnant women in France choose not to join randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to find out what factors — like age, education, or how the study was explained — might influence their dec…

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This study looked at whether cardiac MRI can accurately measure right heart function in 112 people with pulmonary arterial hypertension. Researchers compared MRI results with data from invasive heart catheterization. The goal was to see if MRI could be used to monitor disease and…

This study reviewed medical records of 901 infants who had surgery for aortic coarctation (a narrowed aorta) before age one. Researchers wanted to find out how many later developed high blood pressure or re-narrowing of the aorta. The goal is to better understand these risks and …

This completed study observed 72 pregnant women with HELLP syndrome in the ICU. Researchers tracked daily changes in platelets, liver enzymes, and lactate dehydrogenase before and after delivery. The goal was to understand how these biological markers evolve, not to test a treatm…

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This study looked at 170 adults having thyroid surgery under general anesthesia to see if the blood pressure difference between the arm and leg changes when they are asleep. Researchers measured blood pressure in both limbs before and during anesthesia. The goal was to understand…

This study looked at 100 patients having a lumbar puncture (spinal tap) to measure pressure inside the skull. Researchers compared that pressure to each person's body fat percentage, measured using a special machine called a Bod Pod. The goal was to see if higher body fat is link…

This study tested whether a series of five one-minute educational videos, shared through community WeChat groups, could improve what people know and do about secondary hypertension. Over 1,000 adults from eight communities in suburban Beijing took part. Researchers measured chang…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new approach that filters out a protein called sFlt-1 from the blood, which may help restore normal blood vessel function. The research is a first step toward a possib…

This study looked at whether keeping indoor temperature at 26°C (about 79°F) can prevent dangerous heat strain in older adults during a multi-day heat wave. Researchers exposed 18 adults aged 60-85 to simulated heat conditions over three days and two nights, measuring core temper…

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This study looked at 42 people who had surgery for multiple torn knee ligaments between 2000 and 2019. Researchers measured knee function and symptoms using standard questionnaires. The goal was to understand how well surgery works for these serious injuries, which can cause long…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study worked with 42 Cherokee citizens to design a program that strengthens community connections and shares cultural knowledge. The goal was to see if this approach could help lower blood pressure and improve mental well-being. The project had two phases: first gathering he…

This study tested whether a single session of low-volume high-intensity interval training or a combination of sauna and cold water immersion can lower blood pressure responses to physical stress. 45 healthy adults aged 18-50 participated. Researchers also looked at whether learni…

This study checked if a Samsung smartwatch can accurately measure blood pressure over a long period. Researchers compared the smartwatch's readings to a standard medical device in 42 healthy adults. The goal was to see if smartwatches could be a reliable tool for tracking blood p…

This small, early study tested whether drinking beetroot juice (which is rich in natural nitrates) could improve artery stiffness and brain blood vessel function in adults aged 50 to 79. Sixteen participants were randomly given either nitrate-rich or nitrate-depleted beetroot jui…

This study looked at how the eye produces and drains fluid to understand why glaucoma medications lower eye pressure more in some people than others. Researchers measured eye fluid production, drainage, and pressure in 59 adults with glaucoma or high eye pressure before and after…

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study followed 80 people with severe obesity who were scheduled for weight-loss surgery to see how well their heart medications were managed and taken. Researchers used blood tests and patient reports to check if blood pressure medicines were being taken as prescribed. The g…

This study looked at whether a planned awareness program could improve knowledge about preventing hypertensive crises in people already diagnosed with high blood pressure. Thirty-five patients took part, and their knowledge was measured before and two weeks after the program. The…

This study looked at how different ventilator pressure levels (PEEP) affect the optic nerve sheath diameter, which is a noninvasive way to estimate brain pressure. Researchers measured this in 105 patients undergoing spine surgery while lying face down. The goal was to see if hig…

This study looked at 149 adults with high blood pressure and insomnia to understand how poor sleep might raise the risk of heart disease. Researchers used a sleep therapy called CBT-I to see if improving sleep could lower nighttime blood pressure. The goal was to learn more about…

This study looked at whether combining virtual simulation with hands-on practice helps midwifery students learn better than virtual training alone. Thirty-two students were split into two groups to practice managing severe preeclampsia. The goal was to see if the combined approac…

This study looked at how giving IV fluids during a C-section affects heart function in women with preeclampsia. Researchers used ultrasound to measure heart output in 34 women. The goal was to better understand how to manage fluids safely in these patients.

This completed study gave 22 healthy men a single dose of semaglutide (Rybelsus) or a placebo pill to see how it affects cortisol and other stress hormones. The goal was not to treat any disease, but to learn more about how GLP-1 drugs interact with the body's stress system. Part…

This study looked at 53 adults having ear surgery (tympanoplasty) with their head turned to the side. Doctors used ultrasound to measure the optic nerve sheath diameter, which can indicate pressure inside the skull. The goal was to see if the sideways head position changes that p…

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify reasons for missed doses. The goal is to understand n…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This completed study looked at how physical activity, life satisfaction, and medication adherence are related in 82 older Turkish adults (65+) with chronic conditions like high blood pressure or diabetes. Researchers used surveys to measure each factor. The goal was to understand…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This completed study looked at 50 adults with high blood pressure to see if dysfunctional breathing (abnormal breathing patterns) is related to how well they can exercise and keep their balance. Participants filled out a breathing questionnaire and performed balance and walking t…

This completed study looked at why people on chronic hemodialysis often have high blood pressure between sessions. Researchers measured weight gain, heart function, and blood chemicals in 32 stable dialysis patients. The goal was to understand the relative roles of fluid gain, ho…

This study tested whether a computer program (Clinical Decision Support System) helps doctors follow official treatment guidelines for patients with both high blood pressure and atrial fibrillation (an irregular heartbeat). Researchers compared clinics using the program to those …

This study looked at how salt in the diet affects blood pressure in 130 adults with chronic kidney disease. Researchers measured a protein called uromodulin in urine to see if it predicts salt sensitivity. The goal was to understand why some patients' blood pressure rises more wi…

This study looked at 24 people with high-altitude pulmonary hypertension who live above 2500 meters. Researchers measured their sleep breathing at 3200 meters and again after moving to 760 meters. The goal was to see if lower altitude improves oxygen levels and reduces breathing …

This study looked at 24 people with high altitude pulmonary hypertension who live above 8,200 feet. Researchers measured how far they could walk in 6 minutes at their home altitude (10,500 feet) and after moving to a lower altitude (2,500 feet). The goal was to see if relocating …

This study looked at 24 people with high altitude pulmonary hypertension (HAPH) who live above 2,500 meters. Researchers measured their lung blood pressure at 3,200 meters and then after moving to 760 meters for one night and seven nights. The goal was to see if simply being at a…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This completed study tested a web-based tool called PedsBP CDS that helps doctors identify and manage high blood pressure in children aged 6-17. The tool was used in 45 primary care clinics across three rural states, involving over 41,000 youth. The goal was to see if the tool im…

This study looked at how two common laparoscopic hernia repair methods (TAPP and TEP) affect pressure inside the eye. Sixty adults with groin hernias had their eye pressure measured before and after surgery. The goal was to understand if the surgical position and gas used during …

This study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…

This study tested whether replacing traditional biomass stoves and kerosene lamps with LPG stoves and solar power improves health in rural Rwanda. Over 1,600 adults and children from 650 households participated. Researchers measured blood pressure and lung function over three yea…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study looked at 120 children with glaucoma or suspected glaucoma who needed eye exams under anesthesia. The goal was to see if a standard anesthesia plan could produce consistent and reliable eye pressure measurements. Researchers measured how deep the anesthesia was and com…

This study looked at the gut bacteria of 192 people, including those with untreated high blood pressure, treated high blood pressure, and healthy individuals. Researchers analyzed stool samples to find differences in bacteria types and functions. The goal was to understand how gu…

This study tested whether a youth-led digital education program could help adults with high blood pressure lower their numbers. Adults and teens (ages 14-24) worked together in pairs: teens learned about hypertension from online modules and then taught the adults. The study enrol…

This study looked at whether a nutrition and behavior change program could help reduce sleep apnea in people who are overweight or obese. About 400 adults took part, and researchers measured changes in sleep apnea risk, daytime sleepiness, and weight loss. The goal was to see if …

This study looked at 142 people with hard-to-treat high blood pressure who had a procedure called renal denervation, which uses energy to calm overactive kidney nerves. Researchers compared two types of sedation—dexmedetomidine versus a fentanyl-propofol combination—to see which …

This study looked at 139 adults with high blood pressure to find out why some blood pressure medicines work better for certain people. Researchers checked things like diet, body size, and genetics to see how they affect drug response. The goal was to learn more about high blood p…

This study tested whether baxdrostat, an experimental drug for high blood pressure, affects the body's stress hormone cortisol. 48 adults with uncontrolled hypertension took baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and after a stimulation t…

This completed study looked at whether a new ultrasound score called VExUS can help doctors better assess risk in people with pulmonary arterial hypertension (PAH). Researchers measured VExUS in 86 adults and compared it to standard tests like heart catheterization and blood mark…

This study follows 202 people who were first checked for sleep apnea as children in 2003. Researchers want to see how their sleep apnea changed over 18 years and whether it is linked to heart problems or thinking difficulties. Participants will repeat sleep tests, blood pressure …

This study looked at how certain immune cells (neutrophils) form web-like structures in women with preeclampsia compared to those with normal pregnancies. Researchers analyzed stored blood samples from 26 women to understand two different ways these webs are made. The goal was to…

This study looked at whether giving extra oxygen can lower blood pressure in the lungs of people who live above 2500 meters and have high altitude pulmonary hypertension. Researchers measured heart changes with ultrasound in 48 highlanders while they breathed either oxygen or reg…

This early-stage study tested a new drug called AD-227 in 70 healthy adults. Researchers wanted to see if taking a single combination tablet works as well as taking two separate pills (AD-227A and AD-227B) in terms of safety and how the drug moves through the body. The study is a…

This study looked at whether ultrasound measurements of the optic nerve sheath (the lining around the eye nerve) can detect changes in brain pressure during open-heart surgery when patients are on a heart-lung machine. Researchers measured the optic nerve sheath diameter in 40 ad…