Sugar-Tweaked heart hormone tested in healthy volunteers
NCT ID NCT07606183
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormone, plus a saline placebo, on separate days. The goal is to understand whether the sugar attachment alters how the hormone works, which could inform future treatments for conditions like heart failure and high blood pressure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
glycosylated atrial natriuretic peptide (gANP) and non-glycosylated ANP
What this could lead to
If successful, this could help researchers understand how a natural sugar modification changes the heart hormone's effects, potentially pointing toward new treatments for high blood pressure or heart failure.
What could go wrong
This is a very early, small study in only 17 healthy young men, not patients. The results may not apply to older or sicker people, and the hormone is given by IV, not as a pill.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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4) Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen, 2400, Denmark