New blood pressure Drug's safety checked in cortisol study

NCT ID NCT06336356

Completed Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether baxdrostat, an experimental drug for high blood pressure, affects the body's stress hormone cortisol. 48 adults with uncontrolled hypertension took baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and after a stimulation test to see if the drug causes any adrenal problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: baxdrostat
What this could lead to: If successful, this study could help understand whether baxdrostat is safe for the adrenal glands in people with high blood pressure.
What could go wrong: This is a small, early-phase study focused on a safety marker, not on treating hypertension. The results may not apply to larger populations or show any clinical benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNCONTROLLED HYPERTENSION

Contacts and locations

Locations

Research Site

Phoenix, Arizona, 85018, United States
Research Site

Tempe, Arizona, 85281, United States
Research Site

Montclair, California, 91763, United States
Research Site

Tarzana, California, 91356, United States
Research Site

Tampa, Florida, 33612, United States
Research Site

Chicago, Illinois, 60643, United States
Research Site

Metairie, Louisiana, 70006, United States
Research Site

Houston, Texas, 77074, United States
Research Site

Houston, Texas, 77099, United States
Research Site

Norfolk, Virginia, 23502, United States

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