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Exercise may sharpen aging brains and hearts in hypertension study

NCT ID NCT01341145

Disease control Sponsor: University of Texas at Austin Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether a 12-week moderate aerobic exercise program can improve brain function, cardiovascular health, and cognition in sedentary adults aged 45-65 with borderline or stage 1 hypertension. Participants are randomly assigned to either aerobic exercise or a progressive muscle relaxation program. The researchers use brain scans and memory tests to measure changes, aiming to understand how physical activity might protect the aging brain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aerobic exercise program
What this could lead to
If successful, this could show that moderate aerobic exercise boosts brain function and cardiovascular health in middle-aged adults with high blood pressure.
What could go wrong
This is a small, early-stage study with only 41 participants, so results may not apply broadly. The relaxation group serves as a control, and benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

41 people

The number who actually took part.

Start date

Mar 2011

Finished

Apr 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sedentary adults Participants will be classified as sedentary if they have not engaged in regular physical exercise for at least one year prior to study enrollment. * Ages 45-65 * Normal blood pressure or Borderline or stage 1 hypertension Borderline hypertension will be defined as systolic blood pressure between 120-139 mmHg and/or diastolic blood pressure between 80-89 mmHg. Stage 1 hypertension will be defined as systolic blood pressure between 140-159 mmHg and/or diastolic blood pressure between 90-99 mmHg. Exclusion Criteria: * Signs or symptoms of chronic heart disease * Smoking (current or within the past 6 months) * Peripheral artery disease (ankle-brachial index\<0.9) * Diabetes (fasting blood glucose\>126 mg/L) * Orthopedic problems that would prohibit participants from participating in exercise. * Axis I psychiatric disorder * Magnetic resonance contraindications * Baseline Intellectual Quotient \< 70 * Below chance performance on the practice items of the cognitive tasks * Evidence of large vessel stroke on magnetic resonance imaging

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • University of Texas at Austin

    Austin, Texas, 78712, United States

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