Ocular hypertension

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This trial tests a new implant that slowly releases the glaucoma drug timolol inside the eye. It is for people with open-angle glaucoma or ocular hypertension who are already having cataract surgery. The study compares three doses of the implant against standard timolol eye drops…

This phase 3 trial tests TFC-003, a new eye drop, in 188 adults with primary open-angle glaucoma or ocular hypertension. Participants use the drops twice daily for up to 24 weeks. The main goal is to see if TFC-003 lowers eye pressure better than an active control. The study is c…

This phase 3 trial tests whether a preservative-free version of bimatoprost eye drops works as well as the standard Lumigan drops for lowering eye pressure. About 600 adults with primary open-angle glaucoma or ocular hypertension in both eyes will receive either the new formulati…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests whether a travoprost drug implant (iDose TR) plus a tiny stent (iStent infinite) can lower eye pressure better than the implant alone in people with open-angle glaucoma or high eye pressure. About 150 adults will receive either the combo or a sham procedure and b…

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This study tests whether a combination eye drop (Rocklatan) works better than a standard drop (Latanoprost) at lowering eye pressure over a full 24-hour period in adults with open-angle glaucoma or ocular hypertension. About 30 participants will use one drop in each eye nightly. …

This study tests whether a quick laser treatment called DSLT can help people with glaucoma or high eye pressure use fewer daily eye drops. Sixty adults whose eye pressure is already controlled with 1-3 types of drops will receive the laser in one or both eyes. Researchers will ch…

This Phase 3 trial tests a second-generation implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The study will enroll 510 adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and effective at …

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

This study tests a redesigned inserter for the travoprost implant, a tiny device placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 30 adults will receive the implant using the updated inserter. The main goal is to see if doct…

This study tests a tiny implant placed inside the eye during cataract surgery that slowly releases travoprost, a drug that lowers eye pressure. About 132 adults with glaucoma or high eye pressure will receive either the implant plus surgery or surgery alone. The goal is to see if…

This Phase 3 trial tests a new eye drop called HUC3-637 in 206 adults with primary open-angle glaucoma or ocular hypertension. The goal is to see if it safely lowers eye pressure better than an existing active control. Participants will use the drops daily and have their eye pres…

This study compares two first-line treatments for primary open-angle glaucoma or high eye pressure: a one-time laser procedure (selective laser trabeculoplasty) versus daily latanoprost eye drops. Researchers will track how well each lowers eye pressure and note any side effects …

This study tests whether adding pilocarpine eye drops after combined cataract and Kahook Dual Blade surgery helps lower eye pressure more than standard drops alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients achieve a 2…

This phase 3 trial tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is to see if…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see if the imp…

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This study tests a new smart contact lens that measures eye pressure continuously for 24 hours, compared to standard spot checks. It involves 12 adults with glaucoma or high eye pressure. The goal is to see if the lens provides accurate readings day and night, which could lead to…

This study compares two new investigational devices for measuring eye pressure against the current standard methods in 200 adults with glaucoma or suspected glaucoma. The goal is to find a more objective, reproducible, and portable way to measure eye pressure. Participants will h…

This study is testing whether an AI-based eye screening program can help detect glaucoma and other eye conditions in people visiting community health centers. About 1,800 adults at higher risk for glaucoma will get a quick eye scan using an AI tool called AI-RONA. If the screenin…

This long-term study is looking for the best methods to detect glaucoma and track its worsening over time, especially in people with nearsightedness (myopia) and those of African or European descent. Researchers will use advanced eye imaging to monitor changes in the back of the …

This study tests whether showing cartoon video clips and using character voices during a visual field test can help children aged 5-8 stay focused and give more reliable results. Twenty children with certain eye conditions will be tested twice, once with the cartoon intervention …

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study tests whether adding brimonidine eye drops can reduce eye redness in people with glaucoma who are already using netarsudil/latanoprost drops. About 35 adults aged 18-65 with open-angle glaucoma or high eye pressure will take part. The main goal is to see if the extra d…

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study compares two eye drop treatments—latanoprost alone versus a combination of netarsudil and latanoprost (Rocklatan)—to see if the combination improves blood flow in the veins around the eye. Researchers will use special imaging techniques to measure blood flow in adults …

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study looks at whether a slow-release injection (Durysta) can replace some daily eye drops for glaucoma, reducing eye surface inflammation. Researchers will measure a marker called caspase-1 in 20 adults with open-angle glaucoma. The goal is to see if fewer drops lead to a h…

This study aims to understand the natural bacteria living on the surface of the eye in both healthy people and those with certain eye conditions. Researchers will collect eye swabs from 500 adults in middle Tennessee to build a database of what a normal eye microbiome looks like.…

This study looks at how changing carbon dioxide (CO2) levels in the blood affects eye pressure and the thickness of a layer behind the retina (choroid) in children. Researchers will adjust breathing during eye exams under anesthesia for 20 children aged newborn to 8 years. The go…

This study looks at whether giving a drug called dexmedetomidine during spine surgery can help keep eye pressure stable when patients are lying face down. High eye pressure during surgery can harm vision. The trial will include 60 adults having planned spine surgery and will meas…