Ocular hypertension

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study compares different ways of performing a laser treatment called selective laser trabeculoplasty (SLT) for people with open-angle glaucoma or high eye pressure. 400 participants will receive SLT using one of several protocols, and researchers will track how much their ey…

This study follows 100 adults with primary open-angle glaucoma who had a goniotomy procedure using the C-Rex surgical instrument. The goal is to see how well the surgery lowers intraocular pressure and reduces the need for glaucoma medications over 12 months. Researchers will als…

This clinical trial tests an implant called PA5108 that is placed inside the eye to lower pressure in adults with open-angle glaucoma or ocular hypertension. The implant is compared to standard latanoprost eye drops. The study aims to find the right dose that is both safe and eff…

This study compares two versions of a three-drug combination eye drop for glaucoma: one with preservatives and one without. Researchers want to see if the preservative-free version is gentler on the eye surface and leads to better treatment adherence. Participants will also use a…

This early-stage trial is testing a single biodegradable implant placed in the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. The implant slowly releases medication over time and then dissolves. The study includes 12 adults and focuses on safety,…

This study follows 116 people with open-angle glaucoma who already have a MINIject implant in their eye. Researchers will track them for up to 5 years to see if any serious device-related problems occur. No new treatment is given—this is a safety check to see how well the implant…

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This study tests whether eye pressure-lowering medication can slow the progression of severe nearsightedness (high myopia) in adults. Researchers will measure changes in eye length and vision over time. The trial includes 152 participants aged 18 to 65 with worsening high myopia …

This study tests an implant called AGN-193408 SR that is placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 100 participants will receive the implant, and some will also get standard eye drops for comparison. The goal is to se…

This study tests a new eye drop called DE-117B in 345 Chinese adults with open-angle glaucoma or high eye pressure. The goal is to see if it safely lowers eye pressure better than an existing drug. Participants use the drops once daily for at least 4 weeks, with long-term follow-…

This study reviews 100 patients with open-angle glaucoma who had two minimally invasive surgeries (Hydrus microstent and iTrack canaloplasty) along with cataract surgery. Researchers want to see if this combination lowers eye pressure and reduces the need for glaucoma medications…

This study looks at the best way to repeat a laser treatment called SLT for people with open-angle glaucoma or high eye pressure. Researchers will compare different treatment methods in 400 participants who were already in an earlier SLT trial. The goal is to see how well repeat …

This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see i…

This study follows 23 people who received a special lens implant that slowly releases a glaucoma drug (bimatoprost) during cataract surgery. Researchers want to see if it keeps eye pressure low and vision clear for up to 7 years. The goal is to learn whether this combination devi…

This study looks at how a common glaucoma eye drop (latanoprost with preservatives) changes the natural bacteria living on the eye's surface. Researchers will compare the eye bacteria of 45 newly diagnosed glaucoma patients before and after at least 6 months of treatment. The goa…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at 116 adults who had glaucoma stent surgery up to 2 years ago. Researchers use a special eye scan (OCT) to check if the tiny stents are in the right position and how that affects eye pressure. The goal is to learn how often stents are misplaced and whether prope…

This study looks at how changing your body position or drinking water can cause temporary spikes in eye pressure. Researchers will measure these changes in healthy volunteers and in people with glaucoma or autonomic dysfunction. The goal is to better understand what challenges th…