New laser method could make glaucoma treatment easier
NCT ID NCT06925477
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see if the simpler DSLT procedure can offer similar benefits with less discomfort and better access to care.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 51 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years. * Diagnosed with OAG (including exfoliative/pigmentary glaucoma) or OHT. * Gonioscopically visible scleral spur for 360 degrees. * Ability to provide informed consent. * In good health, without prior laser trabeculoplasty, with decision to treat made by an ophthalmologist on the basis of risk profile, patient preference, or both. * Each eye with one of the following qualifying diagnoses (diagnoses may differ between eyes): * High-risk ocular hypertension (OHT): IOP \> 21 mmHg without glaucomatous optic neuropathy (excavation, diffuse or focal thinning or notching of the neuroretinal rim, visible nerve fiber layer defects, or asymmetry of the vertical cup-to-disc ratio of \>0.2 between eyes) \[enrollment of trial participants with High-risk OHT will be capped at 25% of total enrollment\] * Mild primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation \>-6.0 dB with no points in the central 5° \<15 dB * Moderate primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation -6.0 dB to \>-12 dB and no more than 1 central 5° point \<15 dB Exclusion Criteria: * Advanced POAG in either eye * Glaucoma other than OAG (including pigmentary and pseudoexfoliation glaucoma) in either eye * Mean IOP \> 35 mmHg at either the screening or baseline visit in either eye * Narrow or closed angle (Shaffer Grade 0, 1, or 2) in either eye * Contraindications to SLT, brimonidine, apraclonidine, or any other study intervention * Any corneal pathology that would preclude accurate assessment of IOP by Goldmann tonometry in either eye * Any intraocular surgical procedure within the past 6 months in either eye * Inability to attend all scheduled study visits * Pregnancy or plan to become pregnant in the next 1 year * Any prior laser trabeculoplasty, including ALT, MLT and SLT.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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MUSC Health West Ophthalmology Clinic
Charleston, South Carolina, 29407, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Personalized coaching may boost glaucoma treatment adherence
- Can a tiny eye surgery keep glaucoma in check for years?
- Can a new eye test match the gold standard for glaucoma?
- Which laser best tames glaucoma pressure?